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Authors: Fleiner, Tim | Dauth, Hannah | Zijlstra, Wiebren | Haussermann, Peter

Article Type: Short Communication

Abstract:  Physical exercise is an effective treatment approach for neuropsychiatric symptoms (NPS), but it is unknown whether the reduction of NPS has an impact on professional caregiver’s burden. A randomized controlled trial in acute dementia care with N  = 70 patients, n  = 35 per group, was conducted. The intervention group (IG) received an exercise program, the control group a social stimulation program. The RM-ANOVA showed a significant group x time interaction with time effects for the IG and decreased caregiver burden due to the exercise program at follow-up. Physical exercise programs may not only be beneficial for the patients but also for …their professional caregivers. Show more

Keywords: dementia, hospital care, neuropsychiatric symptoms, professional caregiver’s burden, structured exercise, DRKS00006740 (German Clinical Trial Register)

DOI: 10.3233/JAD-191102

Citation: Journal of Alzheimer's Disease, vol. 74, no. 2, pp. 429-433, 2020

Authors: Fleiner, Tim | Leucht, Stefan | Förstl, Hans | Zijlstra, Wiebren | Haussermann, Peter

Article Type: Research Article

Abstract: Observational and interventional studies indicate a direct link between the patients’ physical activity and the extent of behavioral and psychological symptoms of dementia (BPSD). At present, there are no evidence-based recommendations for physical exercise in the acute dementia care settings. Hence, this systematic review investigates the effects of short-term exercise trials on BPSD. Trials with a length up to three months investigating the effects of structured exercise interventions on BPSD in acute dementia care settings were included. Five trials, referring to a total of N = 206 patients, met the inclusion criteria. The trial durations ranged from three up to twelve weeks. All trials conducted …three sessions per week of 30 to 45 minutes. Three trials reported significant reductions of BPSD and differences in comparison to the pre-test and control groups. Out of the three trials investigating the effects of exercise interventions on depressive symptoms, one reported significant reduction and two reported no differences in pre-post analysis. Exercise represents a potentially worthwhile approach for the treatment of patients suffering from BPSD. Given the scarcity of available studies, more randomized controlled short-term exercise trials in acute dementia care settings are needed to define appropriate exercise recommendations for clinicians treating these patients. Show more

Keywords: Behavioral symptoms, dementia, exercise, geriatric psychiatry, specialized hospitals

DOI: 10.3233/JAD-160683

Citation: Journal of Alzheimer's Disease, vol. 55, no. 4, pp. 1583-1594, 2017

Authors: Stypa, Vanessa | Haussermann, Peter | Fleiner, Tim | Neumann, Sandra

Article Type: Research Article

Abstract: Background: The Quality of Life–Alzheimer’s Disease (QoL-AD) scale is a widely used measure of quality of life (QoL) in dementia. Although the instrument has been validated in several languages, the psychometric properties of the German self-report version have not yet been analyzed. Objective: This study examines the internal consistency, test-retest reliability, and construct validity of the German QoL-AD self-report scale. Methods: The sample included 30 patients suffering from mild to moderate Alzheimer’s disease or vascular dementia (19 females; mean age 77.3 years; mean Mini-Mental State Examination (MMSE) score 19.7 points). To determine test-retest reliability, the QoL-AD self-report scale was re-administered …four to seven days apart. For construct validity analysis, the Dementia Quality of Life instrument (DQoL), Geriatric Depression Scale (GDS), MMSE, and an adapted short form of the Neuropsychiatric Inventory (NPI) were used. Results: The German QoL-AD self-report scale shows an internal consistency of α = 0.79 and a test-retest reliability of r  = 0.75 (p  < 0.01). Regarding construct validity, there was a significant positive correlation between the total scores of the QoL-AD and DQoL (r  = 0.47, p  < 0.05). The analysis revealed no significant correlations with the GDS or the adapted NPI. No association could be observed between the QoL-AD and the MMSE (r  = 0.01), confirming divergent validity. Conclusion: The results indicate that the German QoL-AD self-report scale is a suitable instrument for assessing QoL in patients suffering from mild to moderate dementia, thus supporting its use in clinical practice and research. Show more

Keywords: Alzheimer’s disease, dementia, Germany, quality of life, reliability and validity, self report

DOI: 10.3233/JAD-200400

Citation: Journal of Alzheimer's Disease, vol. 77, no. 2, pp. 581-590, 2020