Your search for: 'author:("Jonveaux, Thérèse Rivasseau")' has returned 5 results. (0.033s) Save search

Authors: Jonveaux, Thérèse Rivasseau | Fescharek, Reinhard

Article Type: Research Article

Abstract: The creation of healing gardens for persons with Alzheimer’s disease and related diseases (ADRD) offers vast potential. They can play a role in the scaffolding of cognitive disorders, emotional stress, sensory processing, sense of harmony, and appeasement. These effects are achieved through a distributed interplay of psychological functions with the immediate environment and local culture on the one hand, and dialogue on the other. The garden, a natural canvas created by man, shares with art the ability to foster an esthetic sense for which the perception can be measured by functional neurological imaging exploration. Art represents a mediator for the …collaborative realization of distributed psychological functions between different individuals. Based on the hypothesis of an optimization of the therapeutic potential of a garden by a design adapted to the neuro-psycho-social and cultural specificities of its users combined with the thoughtful introduction of an artistic dimension, the “art, memory and life ” healing garden was created at the University Hospital of Nancy as a prototype for persons with ADRD. The design concept was based on two hypotheses that we formulate herein, discuss their theoretical foundation, and suggest enhanced design for therapeutic gardens based upon our experience. Show more

Keywords: Alzheimer’s disease, art, beauty, cognition, healing gardens, interaction

DOI: 10.3233/JAD-170781

Citation: Journal of Alzheimer's Disease, vol. 61, no. 3, pp. 885-898, 2018

Authors: Jardel, Amory | Hopes, Lucie | Malaplate, Catherine | Roch, Véronique | Manca, Chloé | Jonveaux, Thérèse Rivasseau | Verger, Antoine

Article Type: Short Communication

Abstract: This longitudinal study evaluates the prognostic impact of amyloid PET in patients suspected of Alzheimer’s disease and presenting with isolated cerebrospinal fluid (CSF) increases in P-Tau proteins (NCT02556502). The rate of conversion, based on the DSM-5 criteria and all collected data (average follow-up of 39.2±13.2 months), was determined by a panel of experts blinded to the PET results and was 75%(6/8) for positive and 35%(6/17) for negative baseline amyloid PET. In this population with isolated CSF increases in P-Tau, a positive baseline amyloid PET was associated with greater than twice the proportion of dementia conversions within the following three years.

Keywords: Alzheimer’s disease, amyloid PET, cerebrospinal fluid, conversion, longitudinal

DOI: 10.3233/JAD-201435

Citation: Journal of Alzheimer's Disease, vol. 80, no. 4, pp. 1389-1394, 2021

Authors: Gervaise-Henry, Christelle | Watfa, Gasshan | Albuisson, Eliane | Kolodziej, Allan | Dousset, Brigitte | Olivier, Jean-Luc | Jonveaux, Thérèse Rivasseau | Malaplate-Armand, Catherine

Article Type: Research Article

Abstract: Background: Alzheimer’s disease (AD) cerebrospinal fluid (CSF) biomarkers have recently been included in the criteria for AD diagnosis. Unfortunately, their wider use in routine and interpretation require more standardization, particularly for the pre-analytical steps. In particular, amyloid-β (Aβ)42 peptide measurement is strongly influenced by the type of collection tube and by repeated freeze/thaw cycles. Objective : The objectives of this study were to compare, in clinical setting, the impact of collection tubes and the repetition of freeze/thaw cycles on Aβ42 and Aβ40 concentrations and consequently determine if the Aβ42 /Aβ40 ratio could resolve the diagnosis difficulties related to these pre-analytical …parameters. Methods : CSF from 35 patients was collected in different polypropylene (PP) and stored at – 80°C after sampling. For CSF collected in the reference tube, three successive freeze-thaw cycles were done. Aβ42 and Aβ40 concentrations were determined in each condition in order to calculate the Aβ42 /Aβ40 ratio. Results : Our results showed that CSF Aβ42 and Aβ40 values were significantly different according to the type of collection tube and the number of freeze/thaw cycles. Although the calculation of the Aβ42 /Aβ40 ratio eliminated the effect of PP tube-dependent variation, this was not the case for freeze-thaw cycle-associated variation. Conclusion : The use of Aβ42 /Aβ40 ratio rather than Aβ42 alone could contribute toward pre-analytical standardization, thus allowing the general use of CSF AD biomarkers in routine practice. Show more

Keywords: Alzheimer’s disease, Aβ40 peptide, Aβ42/Aβ40 ratio, Aβ42 peptide, cerebrospinal fluid, pre-analytical standardization, tube, freeze-thaw cycles

DOI: 10.3233/JAD-160865

Citation: Journal of Alzheimer's Disease, vol. 57, no. 2, pp. 437-445, 2017

Authors: Jonveaux, Therese Rivasseau | Batt, Martine | Fescharek, Reinhard | Benetos, Athanase | Trognon, Alain | Bah Chuzeville, Stanislas | Pop, Alina | Jacob, Christel | Yzoard, Manon | Demarche, Laetitia | Soulon, Laure | Malerba, Gabriel | Bouvel, Bruno

Article Type: Research Article

Abstract: The French Alzheimer Plan 2008–2012 anticipates the implementation of new Units specialized in cognitive rehabilitation and psycho-behavioral therapy of Alzheimer's disease (AD) patients. Conceived for AD and other dementia patients of all ages, their objectives are to propose a cognitive rehabilitation program, to prevent or treat psycho-behavioral crises, and to provide support and educational therapy to the family and professional caregivers, in order to ease the patient's return to his or her previous way of life. Studies on green spaces and healing gardens in health-care settings have revealed objective and measurable improvements in the patient's well-being. The Plan officially stipulates …for the first time the need to make healing gardens an integral part of these Units, but it does not provide specific recommendations or criteria for implementing such gardens. Although green spaces and gardens are available in many French Care Units, they are rarely specifically adapted to the needs of AD patients. In Nancy, the Art, Memory and Life garden, a specific concept guided by a neuropsychological approach, was developed and complemented by an artistic vision based on cultural invariants. The main objective of this article is to describe the various steps of the process that led to the creation of this garden: the collection of experiences and information by a pilot group, surveys of patients, visitors, and caregivers before and after establishment of the garden, and implementation of a multi-professional group project. The specifications, the organizational criteria, the therapeutic project, and the criteria for the conception of such a garden stemming from our clinical experience with the Art, Memory and Life garden in Nancy, are described herein. We also present the first assessment following the implementation of the project. Show more

Keywords: Alzheimer's disease, behavioral symptoms, healing garden, hospital units organization, non-pharmacologic therapy, quality of life

DOI: 10.3233/JAD-121657

Citation: Journal of Alzheimer's Disease, vol. 34, no. 1, pp. 325-338, 2013

Authors: Manca, Chloé | Hopes, Lucie | Kearney-Schwartz, Anna | Roch, Véronique | Karcher, Gilles | Baumann, Cédric | Marie, Pierre-Yves | Malaplate-Armand, Catherine | Jonveaux, Thérèse Rivasseau | Verger, Antoine

Article Type: Research Article

Abstract: Background/Objective: The aim of this study was to assess, in routine, the rates with which an amyloid deposition was documented by 18 F-florbetaben PET in patients with suspected Alzheimer’s disease (AD) but with isolated increases in cerebrospinal fluid (CSF) tau-protein concentrations, and the subsequent impact of these PET results on medical management. Methods: This prospective study included 34 patients with mild neurocognitive disorders (MND) and suspected AD (73±9 years, 16 women) and with abnormal CSF concentrations in total-tau (T-tau) and/or phosphorylated-tau (P-tau) proteins but normal Aβ42 concentration and Aβ42 /Aβ40 ratio. These patients were referred to 8 F-florbetaben PET from …which the PET-related changes in the confidence for AD diagnosis (low, intermediate, or high) and treatments were reported. Results: The PET examinations were positive for amyloid deposition (brain amyloid plaque load, BAPL score >1) in none of the 9 patients with an increase in only T-tau proteins and in 8 among the 25 (32%) with an increase in P-tau proteins (one BAPL score of 2 and seven BAPL scores of 3). Knowledge of the PET results was associated with subsequent changes in diagnostic confidence in 44% of patients (15/34) and in the intention-to-treat with a cholinesterase inhibitor drug in 18% (6/34). Conclusion: In patients with suspected AD and isolated increase in CSF tau protein concentrations, an amyloid deposition is documented by 18 F-florbetaben PET in as much as one third of cases when the concentration of P-tau is abnormal, and PET results are associated with significant further changes in medical management. Show more

Keywords: Alzheimer’s disease, amyloid, cerebrospinal fluid, positron emission tomography

DOI: 10.3233/JAD-181146

Citation: Journal of Alzheimer's Disease, vol. 68, no. 3, pp. 1061-1069, 2019