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Authors: Tang, Hui-Dong | Zhou, Yi | Gao, Xiang | Liang, Liang | Hou, Miao-Miao | Qiao, Yuan | Ma, Jian-Fang | Chen, Sheng-Di

Article Type: Research Article

Abstract: Background: China is facing a continuously rising numbers of people with cognitive impairment (CI). Objectives: To investigate the prevalence and risk factors of CI among elderly people living in rural and urban communities. Methods: We conducted a face-to-face survey of CI on 7,900 individuals aged 50 years or older meeting inclusion criteria in the Malu (rural community, n  = 4,429) and Wuliqiao (urban community, n  = 3,471) communities of Shanghai. The Mini-Mental State Examination (MMSE) was used to evaluate the cognitive function. Information on demographic features and potential risk factors for CI was collected during the interview. Multivariate logistic regression was performed …to identify risk factors associated with CI. Results: Based on the education modified MMSE score, we identified 329 CI cases in rural community and 227 in urban community. The prevalence of CI was 7.43% in rural population and 6.54% in urban population (p  = 0.13). In the urban population, risk of having CI was associated with age (OR = 1.04; 95% CI: 1.01–1.08), lack of physical activities (OR = 2.25; 95% CI: 1.11–4.57), presence of diabetes mellitus (OR = 1.79; 95% CI: 1.04–3.07), and having three or more children (OR = 2.39; 95% CI: 1.27–4.50). In contrast, factors associated with rural populations included female gender (OR = 2.03; 95% CI: 1.08–3.82), age (OR = 1.06; 95% CI: 1.03–1.08), exposure to pesticides (OR = 4.68; 95% CI: 1.27–17.21), history of encephalitis or meningitis (OR = 6.02; 95% CI: 1.92–18.85) and head trauma (OR = 1.89; 95% CI: 1.10–3.24). Conclusions: Urban rural and populations showed different risk factors for CI, suggesting that different preventive strategies in these areas should be performed. Show more

Keywords: Cognitive impairment, prevalence, risk factors, rural population, urban population

DOI: 10.3233/JAD-150748

Citation: Journal of Alzheimer's Disease, vol. 49, no. 4, pp. 917-925, 2016

Authors: Cui, Pei-Jing | Zheng, Lan | Cao, Li | Wang, Ying | Deng, Yu-Lei | Wang, Gang | Xu, Wei | Tang, Hui-Dong | Ma, Jian-Fang | Zhang, Ting | Ding, Jian-Qing | Cheng, Qi | Chen, Sheng-Di

Article Type: Short Communication

Abstract: We conducted a case-control study to determine the prevalence of the CALHM1 P86L polymorphism (rs2986017) in patients with Alzheimer's disease (AD) in the Chinese population of mainland China, and also to clarify whether this polymorphism is a risk factor for AD. Fourteen heterozygous P86L carriers were identified among 198 AD patients. One control subject was also found to be a P86L heterozygous carrier. The allelic frequencies of the AD patients and control subjects were found to be significantly different. Our study indicates that the CALHM1-P86L polymorphism is associated with AD in the ethnic Chinese Han.

Keywords: Alzheimer's disease, CALHM1, P86L, polymorphism

DOI: 10.3233/JAD-2010-1207

Citation: Journal of Alzheimer's Disease, vol. 19, no. 1, pp. 31-35, 2010