Your search for: 'author:("Ou, Yang-Ming")' has returned 3 results. (0.016s) Save search

Authors: Anderson, Maria | Xu, Feng | Ou-Yang, Ming-Hsuan | Davis, Judianne | Van Nostrand, William E. | Robinson, John K.

Article Type: Research Article

Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is the leading cause of dementia in the elderly. Amyloid-β protein (Aβ) depositions in both the brain parenchyma and the cerebral vasculature are recognized as important pathological components that contribute to the cognitive impairments found in individuals with AD. Because pharmacological options have been minimally effective in treating cognitive impairment to date, interest in the development of preventative lifestyle intervention strategies has increased in the field. One controversial strategy, cognitive-specific stimulation, has been studied previously in human participants and has been widely commercialized in the form of ‘brain-training games.’ In the present …study, we developed a highly controlled, isolated cognitive training intervention program for mice. Two transgenic mouse lines, one that develops Aβ deposition largely in brain parenchyma, and another in the cerebral microvasculature, progressed through a series of domain-specific tasks for an average of 4 months. Despite the high intensity and duration of the intervention, we found little evidence of positive benefits for AD amyloid pathologies and post-training cognitive testing in these two models. Taken together, these results support the current evidence in human studies that cognitive-specific stimulation does not lead to a measurable reduction in AD pathology or an improvement in general brain health. Show more

Keywords: Alzheimer’s disease, amyloid-beta, Barnes maze, cerebral amyloid angiopathy, cognitive training, transgenic mouse

DOI: 10.3233/JAD-160674

Citation: Journal of Alzheimer's Disease, vol. 55, no. 3, pp. 1109-1121, 2017

Authors: Li, Lin | Cheng, Gui-Rong | Liu, Dan | Hu, Fei-Fei | Gan, Xu-Guang | Zhang, Bo | An, Lina | Chen, Cong | Zou, Ming-Jun | Xu, Lang | Ou, Yang-Ming | Chen, Yu-Shan | Li, Jin-Quan | Wei, Zhen | Wu, Qiong | Chen, Xing-Xing | Guo, Man-Qing | Wu, Qing-Ming | Wang, Ru | Zeng, Yan

Article Type: Research Article

Abstract: Background: Despite the improved access to health services in China, inadequate diagnosis and management of dementia are common issues, especially in rural regions. Objective: The Hubei Memory & Aging Cohort Study was designed as a prospective study in Central China to determine the prevalence, incidence, and risk factors for dementia and mild cognitive impairment (MCI) among urban and rural older adults. Methods: From 2018–2020, participants aged ≥65 years were screened, and data regarding their life behaviors, families, socio-economic status, physical and mental health, social and psychological factors, and cognition were collected. Diagnoses of MCI and dementia were made via consensus …diagnosis using the Diagnostic and Statistical Manual of Mental Disorders fourth edition criteria. Results: Of 8,221 individuals who completed their baseline clinical evaluation, 4,449 (54.1%) were women and 3,164 (38.4%) were from remote rural areas (average age: 71.96 years; mean education period: 7.58 years). At baseline, 25.98%(95%confidence interval [CI]: 24.99–26.96) and 7.24%(95%CI: 6.68–7.80) of the participants were diagnosed with MCI and dementia, respectively. Prevalence showed a strong relationship with age. The substantial disparities between rural and urban regions in MCI and dementia prevalence and multiple dementia-related risk factors were revealed. Especially for dementia, the prevalence rate in rural areas was 2.65 times higher than that in urban regions. Conclusion: Our results suggested that public health interventions are urgently needed to achieve equitable diagnosis and management for people living with dementia in the communities across urban and rural areas. Show more

Keywords: Community aging cohort, cognition, dementia, psychosocial factors, social connections

DOI: 10.3233/JAD-215129

Citation: Journal of Alzheimer's Disease, vol. 85, no. 2, pp. 561-571, 2022

Authors: Xie, Xin-Yan | Huang, Lin-Ya | Cheng, Gui-Rong | Liu, Dan | Hu, Fei-Fei | Zhang, Jing-Jing | Han, Gang-Bin | Liu, Xiao-Chang | Wang, Jun-Yi | Zhou, Juan | Zeng, De-Yang | Liu, Jing | Nie, Qian-Qian | Song, Dan | Yu, Ya-Fu | Hu, Chen-Lu | Fu, Yi-Di | Li, Shi-Yue | Cai, Cheng | Cui, Yu-Yang | Cai, Wan-Ying | Li, Yi-Qing | Fan, Ren-Jia | Wan, Hong | Xu, Lang | Ou, Yang-Ming | Chen, Xing-Xing | Zhou, Yan-Ling | Chen, Yu-Shan | Li, Jin-Quan | Wei, Zhen | Wu, Qiong | Mei, Yu-Fei | Tan, Wei | Song, Shao-Jun | Zeng, Yan

Article Type: Research Article

Abstract: Background: As a prodromal stage of dementia, significant emphasis has been placed on the identification of modifiable risks of mild cognitive impairment (MCI). Research has indicated a correlation between exposure to air pollution and cognitive function in older adults. However, few studies have examined such an association among the MCI population inChina. Objective: We aimed to explore the association between air pollution exposure and MCI risk from the Hubei Memory and Aging Cohort Study. Methods: We measured four pollutants from 2015 to 2018, 3 years before the cognitive assessment of the participants. Logistic regression models were employed to calculate odds …ratios (ORs) to assess the relationship between air pollutants and MCI risk. Results: Among 4,205 older participants, the adjusted ORs of MCI risk for the highest quartile of PM2.5 , PM10 , O3 , and SO2 were 1.90 (1.39, 2.62), 1.77 (1.28, 2.47), 0.56 (0.42, 0.75), and 1.18 (0.87, 1.61) respectively, compared with the lowest quartile. Stratified analyses indicated that such associations were found in both males and females, but were more significant in older participants. Conclusions: Our findings are consistent with the growing evidence suggesting that air pollution increases the risk of mild cognitive decline, which has considerable guiding significance for early intervention of dementia in the older population. Further studies in other populations and broader geographical areas are warranted to validate these findings. Show more

Keywords: Air pollution, Hubei Memory and Aging Cohort Study, mild cognitive impairment, older Chinese population

DOI: 10.3233/JAD-231186

Citation: Journal of Alzheimer's Disease, vol. 98, no. 3, pp. 941-955, 2024