Your search for: 'author:("Pujadas, Francesc")' has returned 2 results. (0.009s) Save search

Authors: Cuberas-Borrós, Gemma | Roca, Isabel | Boada, Mercè | Tárraga, Lluís | Hernández, Isabel | Buendia, Mar | Rubio, Lourdes | Torres, Gustavo | Bittini, Ángel | Guzmán-de-Villoria, Juan A. | Pujadas, Francesc | Torres, Mireia | Núñez, Laura | Castell, Joan | Páez, Antonio

Article Type: Research Article

Abstract: Background: Recently, modifications of Aβ1-42 levels in CSF and plasma associated with improvement in memory and language functions have been observed in patients with mild-moderate Alzheimer’s disease (AD) treated with plasma exchange (PE) with albumin replacement. Objective: To detect structural and functional brain changes in PE-treated AD patients as part of a Phase II clinical trial. Methods: Patients received between 3 and 18 PE with albumin (Albutein® 5%, Grifols) or sham-PE (controls) for 21 weeks (divided in one intensive and two maintenance periods) followed by 6-month follow-up. Brain perfusion assessed by SPECT scans using an automated software (NeuroGam® ) and …brain structural changes assessed by MRI were performed at weeks 0 (baseline), 21, and 44 (with additional SPECT at weeks 9 and 33). Statistical parametric mapping (voxel-based analysis, SPM) and Z-scores calculations were applied to investigate changes to baseline. Results: 42 patients were recruited (39 evaluable; 37 analyzed: 18 PE-treated; 19 controls). There was a trend toward decreasing hippocampi and total intracranial volume for both patient groups during the study (p  < 0.05). After six months, PE-treated patients had less cerebral perfusion loss than controls in frontal, temporal, and parietal areas, and perfusion stabilization in Brodmann area BA38-R during the PE-treatment period (p  < 0.05). SPM analysis showed stabilization or absence of progression of perfusion loss in PE-treated patients until week 21, not observed in controls. Conclusions: Mild-moderate AD patients showed decreased brain volume and impairment of brain perfusion as expected for the progression of the disease. PE-treatment with albumin replacement favored the stabilization of perfusion. Show more

Keywords: Albumin, Alzheimer’s disease, magnetic resonance imaging, plasma exchange, single-photon emission computed tomography

DOI: 10.3233/JAD-170693

Citation: Journal of Alzheimer's Disease, vol. 61, no. 1, pp. 321-332, 2018

Authors: Espinosa, Ana | Alegret, Montserrat | Pesini, Pedro | Valero, Sergi | Lafuente, Asunción | Buendía, Mar | San José, Itziar | Ibarria, Marta | Tejero, Miguel A. | Giménez, Joan | Ruiz, Susana | Hernández, Isabel | Pujadas, Francesc | Martínez-Lage, Pablo | Munuera, Josep | Arbizu, Javier | Tárraga, Lluis | Hendrix, Suzanne B. | Ruiz, Agustín | Becker, James T. | Landau, Susan M. | Sotolongo-Grau, Oscar | Sarasa, Manuel | Boada, Mercè | for the AB255 Study Group | for the Alzheimer’s Disease Neuroimaging Initiative

Article Type: Research Article

Abstract: The probable-amnestic (Pr-a) mild cognitive impairment (MCI)-storage subtype is a phenotype with 8.5 times more risk of conversion to dementia, mainly Alzheimer’s disease (AD), than the possible non-amnestic (Pss-na) MCI. The aim of this study was to find the optimized cognitive composites (CCs) domain scores most related to neuroimaging biomarkers within Pr-aMCI-storage subtype patients. The Fundació ACE (ACE) study with 20 Pr-aMCI-storage subtype subjects (MCI) were analyzed. All subjects underwent a neuropsychological assessment, a structural MRI, FDG-PET, and PIB-PET. The adjusted hippocampal volume (aHV) on MRI, the standard uptake value ratio (SUVR) on FDG-PET and PIB-PET SUVR measures were analyzed. …The construction of the CCs domain scores, and the aHV on MRI and FDG-PET SUVR measures, were replicated in the parental AB255 study database (n  = 133 MCI). Partial correlations adjusted by age, gender, and education were calculated with the associated p -value among every CC domain score and the neuroimaging biomarkers. The results were replicated in the “MCI due to AD” with memory storage impairments from ADNI. Delayed Recall CC domain score was significantly correlated with PIB-PET SUVR (β= –0.61, p  = 0.003) in the ACE study and also with aHV on MRI (β= 0.27, p  = 0.01) and FDG-PET SUVR (β= 0.27, p  = 0.01) in the AB255 study. After a median survival time of 20.6 months, 85% from the ACE MCI converted to AD. The replication of our results in the ADNI dataset also confirmed our findings. Delayed Recall is the CC domain score best correlated with neuroimaging biomarkers associated with prodromal AD diagnosis. Show more

Keywords: Alzheimer’s disease, amnestic mild cognitive impairment, amyloid, cognition, hippocampus, magnetic resonance imaging, memory, positron emission tomography

DOI: 10.3233/JAD-161223

Citation: Journal of Alzheimer's Disease, vol. 57, no. 2, pp. 447-459, 2017