Nuclear Dbf2-related (NDR) protein kinases are essential components of regulatory pathways involv... more Nuclear Dbf2-related (NDR) protein kinases are essential components of regulatory pathways involved in cell morphogenesis, cell cycle control, and viability in eukaryotic cells. For their activity and function, these kinases require interaction with Mob proteins. However, little is known about how the Mob proteins are regulated. In Candida albicans, the cyclin-dependent kinase (CDK) Cdc28 and the NDR kinase Cbk1 are required for hyphal growth. Here we demonstrate that Mob2, the Cbk1 activator, undergoes a Cdc28-dependent differential phosphorylation on hyphal induction. Mutations in the four CDK consensus sites in Mob2 to Ala significantly impaired hyphal development. The mutant cells produced short hyphae with enlarged tips that displayed an illicit activation of cell separation. We also show that Cdc28 phosphorylation of Mob2 is essential for the maintenance of polarisome components at hyphal tips but not at bud tips during yeast growth. Thus we have found a novel signaling pathwa...
Lecture Notes in Business Information Processing, 2013
ABSTRACT In Modeling Multi agent systems (MAS), the mobility of agent is a basic issue to express... more ABSTRACT In Modeling Multi agent systems (MAS), the mobility of agent is a basic issue to express interactions of flow actions, consequently, modelling migration process is a crucial issue. In this paper, we integrate the Ferber and Müller?s Influence/Reaction model in Agent Petri Nets (APN) to model migration mobile agents. This model clarifies the migration process of agent from an environment to another and enhances its capacity for formal verification.
Lecture Notes in Business Information Processing, 2013
ABSTRACT In Modeling Multi agent systems (MAS), the mobility of agent is a basic issue to express... more ABSTRACT In Modeling Multi agent systems (MAS), the mobility of agent is a basic issue to express interactions of flow actions, consequently, modelling migration process is a crucial issue. In this paper, we integrate the Ferber and Müller?s Influence/Reaction model in Agent Petri Nets (APN) to model migration mobile agents. This model clarifies the migration process of agent from an environment to another and enhances its capacity for formal verification.
Nuclear Dbf2-related (NDR) protein kinases are essential components of regulatory pathways involv... more Nuclear Dbf2-related (NDR) protein kinases are essential components of regulatory pathways involved in cell morphogenesis, cell cycle control, and viability in eukaryotic cells. For their activity and function, these kinases require interaction with Mob proteins. However, little is known about how the Mob proteins are regulated. In Candida albicans, the cyclin-dependent kinase (CDK) Cdc28 and the NDR kinase Cbk1 are required for hyphal growth. Here we demonstrate that Mob2, the Cbk1 activator, undergoes a Cdc28-dependent differential phosphorylation on hyphal induction. Mutations in the four CDK consensus sites in Mob2 to Ala significantly impaired hyphal development. The mutant cells produced short hyphae with enlarged tips that displayed an illicit activation of cell separation. We also show that Cdc28 phosphorylation of Mob2 is essential for the maintenance of polarisome components at hyphal tips but not at bud tips during yeast growth. Thus we have found a novel signaling pathwa...
Lecture Notes in Business Information Processing, 2013
ABSTRACT In Modeling Multi agent systems (MAS), the mobility of agent is a basic issue to express... more ABSTRACT In Modeling Multi agent systems (MAS), the mobility of agent is a basic issue to express interactions of flow actions, consequently, modelling migration process is a crucial issue. In this paper, we integrate the Ferber and Müller?s Influence/Reaction model in Agent Petri Nets (APN) to model migration mobile agents. This model clarifies the migration process of agent from an environment to another and enhances its capacity for formal verification.
Lecture Notes in Business Information Processing, 2013
ABSTRACT In Modeling Multi agent systems (MAS), the mobility of agent is a basic issue to express... more ABSTRACT In Modeling Multi agent systems (MAS), the mobility of agent is a basic issue to express interactions of flow actions, consequently, modelling migration process is a crucial issue. In this paper, we integrate the Ferber and Müller?s Influence/Reaction model in Agent Petri Nets (APN) to model migration mobile agents. This model clarifies the migration process of agent from an environment to another and enhances its capacity for formal verification.
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