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This systematic review analyses research that introduces commercial design applications that could be adopted for suicide prevention in homes. Furthermore, this literature review captures social, spatial and biophilic design methods to improve wellness in homes using environmental design psychology. Safety and human wellness frame this spatial design research that examines means and access restriction to improve home safety and prevent suicides. Suicide is a growing phenomenon that deserves specific attention to how environments can impact or restrict events. There is a substantial evidence base to evaluate suicide prevention methods used in high-risk environments of health and healing environments, workplaces and incarceration facilities. This review outlines design methods using spatial arrangement and material choices to improve human wellness in homes. The effects of biochemical reactions, such as those studied in toxicology, and stress are considered in this research to suggest...