Marc Yang

Background: Malaria remains a significant cause of illness for return travellers in Hong Kong. However, the lack of experience of local healthcare providers in tropical medicine and non-specific presenting symptoms may lead to underdiagnosis or delayed diagnosis of the disease. We evaluate patients presenting with malaria to a local emergency department to understand the disease presentation and outcome. Methods: A retrospective review of all patients diagnosed with malaria presenting to the emergency department from January 2009 to December 2019 was conducted. Information about patient demographics, travel history, presenting vital signs and blood results, how the diagnosis is made, clinical features and outcomes were analysed. Subgroup analysis was also performed for comparison. Results: Among the 70 patients diagnosed with malaria, most of them were imported cases (98.6%). Most were infected with Plasmodium Falciparum (50%) and Plasmodium vivax (45.7%). The common presenting symptoms included fever (100%), nausea or vomiting (42.9%) and headache (38.6%). 43 out of 70 cases had a diagnosis made in the emergency department, either by malarial blood smear (34.3%) or incidental haematological findings (27.1%). Most cases could be discharged uneventfully (90%), with six cases requiring Intensive Care Unit admission during the stay (8.6%). Patients with diagnoses not made in AED had a significantly lower mean arterial pressure (p = 0.009) and haemoglobin level (p = 0.004). Significantly lower platelet count (p = 0.002) and higher bilirubin level (p = 0.041) were found in patients who required ICU admission. For those who had AED reattendance before diagnosis was made, their creatinine levels were significantly higher (p = 0.022) and had a longer length of stay (p = 0.021). Conclusions: The clinical presentation of imported malaria cases is nonspecific, and high suspicion of malaria should be raised when diagnosing febrile patients with a travel history. The history of taking malarial chemoprophylaxis is essential and should have been included in most cases. Malarial-specific treatments were rarely given in the emergency department despite diagnosis. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Objectives and Background
Pelvic fracture causes significant mortality and morbidities. The purpose of this study is to identify the characteristics of patients with pelvic fracture in Hong Kong and to determine the factors predicting mortality. The result could help to identify high-risk patients who might benefit from more intensive evaluation and intervention.

Method:
Five hundred and eight patients (age > 12 years old) with pelvic fractures were identified from the trauma registries of four designated trauma centres in Hong Kong from 1 January 2005 to 31 December 2012. Patient baseline characteristics and outcomes were analysed. Stepwise logistic regression was performed to identify independent clinical predictors for mortality.

Result:
Mean age was 45.4 ± 19.2 years, 43.3% were female, mean length of hospital stay was 27.9 ± 42.4 days and mean length of intensive care unit stay was 4.8 ± 6.8 days. Injury severity score was 28.9 ± 18.7, revised trauma score was 7.2 ± 2 and 30-day mortality was 20.9%. Stepwise logistic regression identified patient’s age, presenting systolic blood pressure, initial Glasgow Coma Scale, injuries to the thoracic and abdominal regions, first base excess and the volume of red blood cell transfusion required within the first 6 h to be independent risk factors predicting mortality.

Conclusion:
Pelvic fracture is associated with significant risk of mortality in major trauma patients. Clinical characteristics obtained during emergency department resuscitation can help in selecting patients for timely aggressive interventions

Background: While there are intrinsic differences in the pros and cons between plain radiographs and computer tomography, the role of pelvic radiographs in polytrauma management is diminishing as computer tomography scans are becoming more accessible. Previous studies found varying results in the inter-observer agreement in pelvic radiograph interpretations. Objectives: To evaluate inter-observer agreement of classifying pelvic fractures in major trauma patients by emergency physicians, and the inter-method agreement between plain radiographs and computer tomography scans. Methods: Three hundred sixty-nine patients with pelvic trauma were recruited from the trauma registries of four designated trauma centres in Hong Kong, each having one set of anteroposterior pelvic radiographs and pelvic computer tomography scans. Pelvic radiographs were classified by two emergency physicians using Young-Burgess classification, and pelvic computer tomography scans classified by an experienced radiologist. Disagreed pelvic radiographs were evaluated by a senior emergency physician to make a final decision before comparing with computer tomography scans. Cohen's kappa was used to measure the inter-observer and the inter-method agreements, in the groups 'mechanism of injury', 'stable versus unstable fractures' and 'complete classification'. Results: Inter-observer agreements of plain radiograph classification for 'mechanism of injury', 'stable versus unstable fractures' and 'complete classification' were moderate to substantial (κ = 0.72, 0.60 and 0.55, respectively). Inter-method agreement for the three groups between plain radiographs and computer tomography were fair to moderate (κ = 0.42, 0.59 and 0.38, respectively). Conclusion: The inter-method agreement between plain pelvic radiographs and computer tomography scans was fair in classifying pelvic fractures, and moderate in detection of unstable pelvic fractures. If the patient is haemodynamically unstable or when computer tomography is unavailable, it is reasonable to obtain plain radiographs to screen for unstable

Introduction: Emergency departments (EDs) play an important role in the early identification and management of sepsis. Little is known about local EDs’ processes of care for sepsis, adoption of international recommendations, and the impact of the new Sepsis-3 definitions.
Methods: Structured telephone interviews based on the United Kingdom Sepsis Trust ‘Exemplar Standards for the Emergency Management of Sepsis’ were conducted from January to August 2017 with nominated representatives of all responding public hospital EDs in Hong Kong, followed by a review of hospital/departmental sepsis guidelines by the investigators.
Results: Sixteen of the 18 public EDs in Hong Kong participated in the study. Among various time-critical medical emergencies such as major trauma, sepsis was perceived by the interviewees to be the leading cause of in-hospital mortality and the second most important preventable cause of death. However, only seven EDs reported having departmental guidelines on sepsis care, with four adopting the Quick Sequential Organ Failure Assessment score or its modified versions. All responding EDs reported that antibiotics were stocked within their departments, and all EDs with sepsis guidelines mandated early intravenous antibiotic administration within 1 to 2 hours of detection. Reported major barriers to
optimal sepsis care included lack of knowledge and experience, nursing human resources shortages, and difficulty identifying patients with sepsis in the ED setting.
Conclusion: There are considerable variations in sepsis care among EDs in Hong Kong. More training, resources, and research efforts should be directed to early ED sepsis care, to improve patient outcomes.