ARHGEF1

ARHGEF1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IAP, 1SHZ, 3AB3, 3ODO, 3ODW, 3ODX, 3P6A
Dynodwyr
Cyfenwau	ARHGEF1, GEF1, LBCL2, LSC, P115-RHOGEF, SUB1.5, Rho guanine nucleotide exchange factor 1, IMD62
Dynodwyr allanol	OMIM: 601855 HomoloGene: 3454 GeneCards: ARHGEF1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • GO:0001948, GO:0016582 protein binding • GO:0005097, GO:0005099, GO:0005100 GTPase activator activity • RNA binding • guanyl-nucleotide exchange factor activity • G protein-coupled receptor binding Cydrannau o'r gell • Cellbilen • bilen • cytoplasm • cytosol Prosesau biolegol • cell population proliferation • regulation of Rho protein signal transduction • Rho protein signal transduction • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • positive regulation of apoptotic process • regulation of small GTPase mediated signal transduction • G protein-coupled receptor signaling pathway • regulation of molecular function Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	9138	n/a
Ensembl	ENSG00000076928	n/a
UniProt	Q92888	n/a
RefSeq (mRNA)	NM_004706 NM_198977 NM_199002	n/a
RefSeq (protein)	NP_004697 NP_945328 NP_945353	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ARHGEF1 yw ARHGEF1 a elwir hefyd yn Rho guanine nucleotide exchange factor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19q13.2.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ARHGEF1.

• LSC
• GEF1
• LBCL2
• SUB1.5
• P115-RHOGEF

Llyfryddiaeth

• "[The exchange factor Arhgef1: a new target in hypertension]. ". Med Sci (Paris). 2010. PMID 20619149.
• "P115 RhoGEF and microtubules decide the direction apoptotic cells extrude from an epithelium. ". J Cell Biol. 2009. PMID 19720875.
• "A novel role for p115RhoGEF in regulation of epithelial plasticity. ". PLoS One. 2014. PMID 24465552.
• "Modification of p115RhoGEF Ser(330) regulates its RhoGEF activity. ". Cell Signal. 2013. PMID 23816534.
• "Modulation of a GEF switch: autoinhibition of the intrinsic guanine nucleotide exchange activity of p115-RhoGEF.". Protein Sci. 2011. PMID 21064165.