CASP9

CASP9
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 4RHW, 1JXQ, 1NW9, 2AR9, 3D9T, 3V3K, 3YGS
Dynodwyr
Cyfenwau	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56, caspase 9
Dynodwyr allanol	OMIM: 602234 HomoloGene: 31024 GeneCards: CASP9
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • cysteine-type peptidase activity • SH3 domain binding • GO:0070122 peptidase activity • GO:0001948, GO:0016582 protein binding • GO:0010577 enzyme activator activity • hydrolase activity • protein kinase binding • cysteine-type endopeptidase activity involved in execution phase of apoptosis • cysteine-type endopeptidase activity • identical protein binding • cysteine-type endopeptidase activity involved in apoptotic signaling pathway • cysteine-type endopeptidase activity involved in apoptotic process Cydrannau o'r gell • cytoplasm • cytosol • mitocondria • apoptosome • cnewyllyn cell • GO:0009327 protein-containing complex Prosesau biolegol • regulation of apoptotic process • response to estradiol • GO:1904578 response to organic cyclic compound • signal transduction in response to DNA damage • cellular response to UV • GO:1904576 response to antibiotic • GO:1904579 cellular response to organic cyclic compound • GO:0010260 heneiddio • platelet formation • glial cell apoptotic process • cellular response to dexamethasone stimulus • proteolysis • cellular response to DNA damage stimulus • response to lipopolysaccharide • positive regulation of neuron apoptotic process • activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c • intrinsic apoptotic signaling pathway in response to DNA damage • extrinsic apoptotic signaling pathway in absence of ligand • regulation of response to DNA damage stimulus • response to cobalt ion • activation of cysteine-type endopeptidase activity involved in apoptotic process • response to UV • execution phase of apoptosis • positive regulation of apoptotic process • GO:0097285 apoptotic process • kidney development • response to ischemia • leukocyte apoptotic process Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	842	n/a
Ensembl	ENSG00000132906	n/a
UniProt	P55211	n/a
RefSeq (mRNA)	NM_001229 NM_001278054 NM_032996	n/a
RefSeq (protein)	NP_001220 NP_001264983 NP_127463	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn CASP9 yw CASP9 a elwir hefyd yn Caspase 9 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 1, band 1p36.21.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn CASP9.

• MCH6
• APAF3
• APAF-3
• PPP1R56
• ICE-LAP6

Llyfryddiaeth

• "Role of Caspase-9 Gene Ex5+32 G>A (rs1052576) Variant in Susceptibility to Primary Brain Tumors. ". Anticancer Res. 2017. PMID 28870924.
• "Effects of Caspase 9 Gene Polymorphism in Patients with Prostate Cancer. ". In Vivo. 2017. PMID 28358701.
• "Activated caspase-9 immunoreactivity in glial and neuronal cytoplasmic inclusions in multiple system atrophy. ". Neurosci Lett. 2016. PMID 27345387.
• "Association of caspase9 promoter polymorphisms with the susceptibility of AML in south Indian subjects. ". Tumour Biol. 2014. PMID 24879622.
• "Silica and double-stranded RNA synergistically induce bronchial epithelial apoptosis and airway inflammation.". Am J Respir Cell Mol Biol. 2014. PMID 24661197.