TNFAIP3

TNFAIP3
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2EQF, 2EQG, 2VFJ, 3DKB, 3OJ3, 3OJ4, 3VUW, 3VUX, 3VUY, 3ZJD, 3ZJE, 3ZJF, 3ZJG, 4ZRH, 4ZS5
Dynodwyr
Cyfenwau	TNFAIP3, A20, OTUD7C, TNFA1P2, AISBL, TNF alpha induced protein 3, AIFBL1
Dynodwyr allanol	OMIM: 191163 HomoloGene: 4582 GeneCards: TNFAIP3
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • cysteine-type peptidase activity • zinc ion binding • metal ion binding • GO:0050372 ubiquitin-protein transferase activity • protease binding • protein self-association • GO:0070122 peptidase activity • ligase activity • kinase binding • K63-linked polyubiquitin modification-dependent protein binding • ubiquitin binding • GO:0001948, GO:0016582 protein binding • catalytic activity • thiol-dependent deubiquitinase • hydrolase activity • identical protein binding • Lys63-specific deubiquitinase activity • transferase activity Cydrannau o'r gell • cytoplasm • cytosol • lysosome • extracellular exosome • cnewyllyn cell • intracellular membrane-bounded organelle Prosesau biolegol • regulation of germinal center formation • positive regulation of hepatocyte proliferation • negative regulation of endothelial cell apoptotic process • negative regulation of interleukin-1 beta production • negative regulation of smooth muscle cell proliferation • regulation of vascular wound healing • B-1 B cell homeostasis • protein K48-linked deubiquitination • GO:1903364 positive regulation of protein catabolic process • negative regulation of cyclin-dependent protein serine/threonine kinase activity • regulation of defense response to virus by host • protein deubiquitination involved in ubiquitin-dependent protein catabolic process • negative regulation of toll-like receptor 2 signaling pathway • negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway • regulation of tumor necrosis factor-mediated signaling pathway • negative regulation of interleukin-6 production • negative regulation of B cell activation • negative regulation of toll-like receptor 5 signaling pathway • tolerance induction to lipopolysaccharide • response to muramyl dipeptide • negative regulation of chronic inflammatory response • negative regulation of cell death • negative regulation of I-kappaB kinase/NF-kappaB signaling • proteolysis • establishment of protein localization to vacuole • protein deubiquitination • negative regulation of protein ubiquitination • protein K48-linked ubiquitination • protein K63-linked deubiquitination • negative regulation of CD40 signaling pathway • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • protein complex oligomerization • protein K11-linked deubiquitination • regulation of inflammatory response • negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway • negative regulation of innate immune response • negative regulation of osteoclast proliferation • negative regulation of tumor necrosis factor production • negative regulation of type I interferon production • metabolaeth • inflammatory response • response to molecule of bacterial origin • negative regulation of NF-kappaB transcription factor activity • negative regulation of interleukin-2 production • negative regulation of inflammatory response • negative regulation of toll-like receptor 3 signaling pathway • nucleotide-binding oligomerization domain containing signaling pathway • cellular response to lipopolysaccharide • negative regulation of toll-like receptor 4 signaling pathway • negative regulation of bone resorption • cellular response to hydrogen peroxide • GO:0097285 apoptotic process • protein ubiquitination • cytoskeleton organization • cell migration • positive regulation of Wnt signaling pathway • protein K29-linked deubiquitination • protein K33-linked deubiquitination Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	7128	n/a
Ensembl	ENSG00000118503	n/a
UniProt	P21580	n/a
RefSeq (mRNA)	NM_001270507 NM_001270508 NM_006290	n/a
RefSeq (protein)	NP_001257436 NP_001257437 NP_006281	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn TNFAIP3 yw TNFAIP3 a elwir hefyd yn TNF alpha induced protein 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 6, band 6q23.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn TNFAIP3.

• A20
• AISBL
• OTUD7C
• TNFA1P2

Llyfryddiaeth

• "rs10499194 polymorphism in the tumor necrosis factor-α inducible protein 3 (TNFAIP3) gene is associated with type-1 autoimmune hepatitis risk in Chinese Han population. ". PLoS One. 2017. PMID 28448618.
• "Three single nucleotide polymorphisms of TNFAIP3 gene increase the risk of rheumatoid arthritis. ". Oncotarget. 2017. PMID 28199970.
• "Associations Between TNFAIP3 Gene Polymorphisms and Rheumatoid Arthritis Risk: A Meta-analysis. ". Arch Med Res. 2017. PMID 28888761.
• "Significant association between TNFAIP3 inactivation and biased immunoglobulin heavy chain variable region 4-34 usage in mucosa-associated lymphoid tissue lymphoma. ". J Pathol. 2017. PMID 28682481.
• "TNFAIP3 gene rs7749323 polymorphism is associated with late onset myasthenia gravis.". Medicine (Baltimore). 2017. PMID 28514294.