Iron oxide nanoparticle (IONP) therapy has diverse health benefits but high doses or prolonged th... more Iron oxide nanoparticle (IONP) therapy has diverse health benefits but high doses or prolonged therapy might induce oxidative cellular injuries especially in the brain. Therefore, we conducted the current study to investigate the protective role of quercetin supplementation against the oxidative alterations induced in the brains of rats due to IONPs. Forty adult male albino rats were allocated into equal five groups; the control received a normal basal diet, the IONP group was intraperitoneally injected with IONPs of 50 mg/kg body weight (B.W.) and quercetin-treated groups had IONPs + Q25, IONPs + Q50 and IONPs + Q100 that were orally supplanted with quercetin by doses of 25, 50 and 100 mg quercetin/kg B.W. daily, respectively, administrated with the same dose of IONPs for 30 days. IONPs induced significant increases in malondialdehyde (MDA) and significantly decreased reduced glutathione (GSH) and oxidized glutathione (GSSG). Consequently, IONPs significantly induced severe brain t...
Canadian Journal of Physiology and Pharmacology, 2015
Diazinon (DZN) is a common organophosphorus insecticide extensively used for agriculture and vete... more Diazinon (DZN) is a common organophosphorus insecticide extensively used for agriculture and veterinary purposes. DZN toxicity is not limited to insects; it also induces harmful effects in mammals and birds. Our experiment evaluated the protective and antioxidant potential of sesame oil (SO) and (or) alpha-lipoic acid (ALA) against DZN toxicity in male Wistar albino rats. DZN-treated animals exhibited macrocytic hypochromic anemia and significant increases in serum biochemical parameters related to liver injury, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), γ-glutamyl transferase (γGT), cholesterol, and triglycerides. They also had elevated levels of markers related to cardiac injury, such as lactate dehydrogenase (LDH) and creatine phosphokinase (CPK), and increased biomarkers of renal injury, urea and creatinine. DZN also increased hepatic, renal, and cardiac lipid peroxidation and decreased antioxidant biomarker levels. SO and (or) ALA supplementation ameliorated the deleterious effects of DZN intoxication. Treatment improved hematology and serum parameters, enhanced endogenous antioxidant status, and reduced lipid peroxidation. Importantly, they exerted synergistic hepatoprotective, nephroprotective, and cardioprotective effects. Our findings demonstrate that SO and (or) ALA supplementation can alleviate the toxic effects of DZN via their potent antioxidant and free radical-scavenging activities.
Spices and herbs are recognized sources of natural antioxidants that can protect from oxidative s... more Spices and herbs are recognized sources of natural antioxidants that can protect from oxidative stress, thus play an important role in chemoprevention of liver diseases. Ginger is used worldwide primarily as a spicy condiment. This study evaluated the ability of ginger extract (GE) to ameliorate oxidative-hepatic toxicity induced by lead acetate (PbAc) in rats. Five groups of animals were used: group I kept as control; groups II, IV, and V received PbAc (1 ppm in drinking water daily for 6 weeks, and kept for an additional 2 weeks without PbAc exposure); group III treated orally with GE (350 mg/kg body weight, 4 d per week) for 6 weeks; group IV (protective) received GE for 2 weeks before and simultaneously with PbAc; and group V (treatment) received GE for 2 weeks after PbAc exposure. GC-MS analysis of GE revealed its content of gingerol (7.09%), quercetin (3.20%), dl-limonene (0.96%), and zingiberene (0.18%). Treatment of PbAc-treated rats with GE has no effect on hepatic Pb concentrations. However, it maintained serum aspartate aminotransferase level, increased hepatic glutathione (157%), glutathione S-transferase (GST) (228%), glutathione peroxidase (GPx) (138%) and catalase (CAT) (112%) levels, and reduced hepatic malondialdehyde (80%). Co-treatment of PbAc group with GE upregulated mRNA expression of antioxidant genes: GST-α1 (1.4-fold), GPx1 (1.8-fold), and CAT (8-fold), while post-treatment with GE upregulated only mRNA expression of GPx1 (1.5-fold). GE has an antioxidant protective efficacy against PbAc-induced hepatotoxicity, which appears more effective than its therapeutic application. However, the changes in antioxidant gene expression were not reflected at the protein level.
Recently, nanomaterials (NMs) have started playing a fundamental role in human life and health, o... more Recently, nanomaterials (NMs) have started playing a fundamental role in human life and health, owing to their substantial beneets of biomedical applications, like medical imaging, disease diagnoses, drug delivery, cancer treatment, gene therapy, and so on. Moreover, the potent antioxidant property displayed by some NMs is opening exciting potentials to develop new therapies with enhanced and targeted actions. For instance, fullerenes, cerium oxide, gold, silver, and selenium NPs have been shown to be eecient redox active radical scavenging materials, due to their ability to reduce oxidative stress in living cells. On the other hand, oxidative stress or redox state imbalance is a major adverse eeect of certain NMs particularly metallic and metallic oxides structured NMs such as titanium dioxide (TiO), nickel oxide (NiO), zinc oxide (ZnO), silica (Si), and cupper (Cu) NMs owing to their intrinsic ability to generate damaging radicals and participate in redox reactions. In this regard, a better understanding of the mechanisms by which NMs induce their activity in exposed organisms has intensively increased in the last decade and remain the primary focus of many investigators. is special issue is dedicated to integrating the previous and the current biological mechanisms of redox nanomaterials in initiating or ameliorating oxidative stress and associated diseases. We cordially invite researchers to contribute their original articles and reviews in our special issue. Potential topics include but are not limited to the following: Synthesis, characterization, and pharmacotoxicological aspects of redox active nanomaterials Pharmacological/clinical applications of antioxidants nanomaterials Implication of antioxidant nanomaterials for controlling diseases Novel antioxidants nanostructures and their mechanisms of action Molecular pathways of antioxidants and oxidants nanostructured materials Assessment of the toxicity and antioxidant activity of redox nanomaterials Modeling of nanomaterials interactions with cellular molecules Nanomaterials-mediated eeects of oxidative stress at the molecular, biochemical, cellular, and disease levels Potential exposure biomarkers of redox active nanomaterials Authors can submit their manuscripts through the Manuscript Tracking System at
Iron oxide nanoparticle (IONP) therapy has diverse health benefits but high doses or prolonged th... more Iron oxide nanoparticle (IONP) therapy has diverse health benefits but high doses or prolonged therapy might induce oxidative cellular injuries especially in the brain. Therefore, we conducted the current study to investigate the protective role of quercetin supplementation against the oxidative alterations induced in the brains of rats due to IONPs. Forty adult male albino rats were allocated into equal five groups; the control received a normal basal diet, the IONP group was intraperitoneally injected with IONPs of 50 mg/kg body weight (B.W.) and quercetin-treated groups had IONPs + Q25, IONPs + Q50 and IONPs + Q100 that were orally supplanted with quercetin by doses of 25, 50 and 100 mg quercetin/kg B.W. daily, respectively, administrated with the same dose of IONPs for 30 days. IONPs induced significant increases in malondialdehyde (MDA) and significantly decreased reduced glutathione (GSH) and oxidized glutathione (GSSG). Consequently, IONPs significantly induced severe brain t...
Canadian Journal of Physiology and Pharmacology, 2015
Diazinon (DZN) is a common organophosphorus insecticide extensively used for agriculture and vete... more Diazinon (DZN) is a common organophosphorus insecticide extensively used for agriculture and veterinary purposes. DZN toxicity is not limited to insects; it also induces harmful effects in mammals and birds. Our experiment evaluated the protective and antioxidant potential of sesame oil (SO) and (or) alpha-lipoic acid (ALA) against DZN toxicity in male Wistar albino rats. DZN-treated animals exhibited macrocytic hypochromic anemia and significant increases in serum biochemical parameters related to liver injury, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), γ-glutamyl transferase (γGT), cholesterol, and triglycerides. They also had elevated levels of markers related to cardiac injury, such as lactate dehydrogenase (LDH) and creatine phosphokinase (CPK), and increased biomarkers of renal injury, urea and creatinine. DZN also increased hepatic, renal, and cardiac lipid peroxidation and decreased antioxidant biomarker levels. SO and (or) ALA supplementation ameliorated the deleterious effects of DZN intoxication. Treatment improved hematology and serum parameters, enhanced endogenous antioxidant status, and reduced lipid peroxidation. Importantly, they exerted synergistic hepatoprotective, nephroprotective, and cardioprotective effects. Our findings demonstrate that SO and (or) ALA supplementation can alleviate the toxic effects of DZN via their potent antioxidant and free radical-scavenging activities.
Spices and herbs are recognized sources of natural antioxidants that can protect from oxidative s... more Spices and herbs are recognized sources of natural antioxidants that can protect from oxidative stress, thus play an important role in chemoprevention of liver diseases. Ginger is used worldwide primarily as a spicy condiment. This study evaluated the ability of ginger extract (GE) to ameliorate oxidative-hepatic toxicity induced by lead acetate (PbAc) in rats. Five groups of animals were used: group I kept as control; groups II, IV, and V received PbAc (1 ppm in drinking water daily for 6 weeks, and kept for an additional 2 weeks without PbAc exposure); group III treated orally with GE (350 mg/kg body weight, 4 d per week) for 6 weeks; group IV (protective) received GE for 2 weeks before and simultaneously with PbAc; and group V (treatment) received GE for 2 weeks after PbAc exposure. GC-MS analysis of GE revealed its content of gingerol (7.09%), quercetin (3.20%), dl-limonene (0.96%), and zingiberene (0.18%). Treatment of PbAc-treated rats with GE has no effect on hepatic Pb concentrations. However, it maintained serum aspartate aminotransferase level, increased hepatic glutathione (157%), glutathione S-transferase (GST) (228%), glutathione peroxidase (GPx) (138%) and catalase (CAT) (112%) levels, and reduced hepatic malondialdehyde (80%). Co-treatment of PbAc group with GE upregulated mRNA expression of antioxidant genes: GST-α1 (1.4-fold), GPx1 (1.8-fold), and CAT (8-fold), while post-treatment with GE upregulated only mRNA expression of GPx1 (1.5-fold). GE has an antioxidant protective efficacy against PbAc-induced hepatotoxicity, which appears more effective than its therapeutic application. However, the changes in antioxidant gene expression were not reflected at the protein level.
Recently, nanomaterials (NMs) have started playing a fundamental role in human life and health, o... more Recently, nanomaterials (NMs) have started playing a fundamental role in human life and health, owing to their substantial beneets of biomedical applications, like medical imaging, disease diagnoses, drug delivery, cancer treatment, gene therapy, and so on. Moreover, the potent antioxidant property displayed by some NMs is opening exciting potentials to develop new therapies with enhanced and targeted actions. For instance, fullerenes, cerium oxide, gold, silver, and selenium NPs have been shown to be eecient redox active radical scavenging materials, due to their ability to reduce oxidative stress in living cells. On the other hand, oxidative stress or redox state imbalance is a major adverse eeect of certain NMs particularly metallic and metallic oxides structured NMs such as titanium dioxide (TiO), nickel oxide (NiO), zinc oxide (ZnO), silica (Si), and cupper (Cu) NMs owing to their intrinsic ability to generate damaging radicals and participate in redox reactions. In this regard, a better understanding of the mechanisms by which NMs induce their activity in exposed organisms has intensively increased in the last decade and remain the primary focus of many investigators. is special issue is dedicated to integrating the previous and the current biological mechanisms of redox nanomaterials in initiating or ameliorating oxidative stress and associated diseases. We cordially invite researchers to contribute their original articles and reviews in our special issue. Potential topics include but are not limited to the following: Synthesis, characterization, and pharmacotoxicological aspects of redox active nanomaterials Pharmacological/clinical applications of antioxidants nanomaterials Implication of antioxidant nanomaterials for controlling diseases Novel antioxidants nanostructures and their mechanisms of action Molecular pathways of antioxidants and oxidants nanostructured materials Assessment of the toxicity and antioxidant activity of redox nanomaterials Modeling of nanomaterials interactions with cellular molecules Nanomaterials-mediated eeects of oxidative stress at the molecular, biochemical, cellular, and disease levels Potential exposure biomarkers of redox active nanomaterials Authors can submit their manuscripts through the Manuscript Tracking System at
Uploads