The problem of haplotype inference under the Mendelian law of inheritance on pedigree genotype data is studied. The minimum recombination principle states that genetic recombinations are rare and haplotypes with fewer recombinations are more likely to ...
Despite the desirable information contained in complex pedigree datasets, analysis methods struggle to efficiently process these datasets. The attractiveness of pedigree data sets is their power for detecting rare variants, particularly in comparison ...
Haplotype Inference (HI) is a computational challenge of crucial importance in a range of genetic studies, such as functional genomics, pharmacogenetics and population genetics. Pedigrees have been shown a valuable data that allows us to infer ...
Springer-Verlag
Berlin, Heidelberg
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