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Forecasting Model for the Annual Growth of Cryogenic Electron Microscopy Data

Published: 15 November 2019 Publication History

Abstract

In this paper, we develop a forecasting model for the growth of Cryogenic Electron Microscopy (Cryo-EM) experimental data time series using autoregressive (AR) model. We employ the optimal modeling order that maximizes the estimation accuracy while maintaining the least normalized prediction error. The proposed model has been efficiently used to forecast the growth of cryo-EM data for the next 10 years, 2019–2028. The time series for the number of released three-dimensional Electron Microscopy (3DEM) images along with the time series of the annual number of 3DEM achieving resolution 10 Å or better are used. The data was collected from the public Electron Microscopy Data Bank (EMDB). The simulation results showed that the optimal model orders to estimate both datasets are and respectively. Consequently, the optimal models obtained an estimation accuracy of and for 3DEM experiments time series and 3DEM resolutions time series, respectively. Hence, the forecasting results reveal an exponential increasing behavior in the future growth of annual released of 3DEM and, similarly, for the annual number of 3DEM achieving resolution 10 Å or better.

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Cited By

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  • (2020)Segmentation-based Feature Extraction for Cryo-Electron Microscopy at Medium ResolutionProceedings of the 11th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics10.1145/3388440.3414711(1-9)Online publication date: 21-Sep-2020
  • (2020)A Divide and Conquer Algorithm for Electron Microscopy SegmentationProceedings of the 11th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics10.1145/3388440.3414700(1-7)Online publication date: 21-Sep-2020

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        Published In

        cover image Guide Proceedings
        Computational Advances in Bio and Medical Sciences: 9th International Conference, ICCABS 2019, Miami, FL, USA, November 15–17, 2019, Revised Selected Papers
        Nov 2019
        209 pages
        ISBN:978-3-030-46164-5
        DOI:10.1007/978-3-030-46165-2

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        Springer-Verlag

        Berlin, Heidelberg

        Publication History

        Published: 15 November 2019

        Author Tags

        1. Protein structure
        2. Electron Microscopy
        3. 3DEM
        4. Single particle
        5. Tomography
        6. X-ray crystallography
        7. NMR
        8. Auto-regressive modeling
        9. Auto-regressive prediction

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        View all
        • (2020)Segmentation-based Feature Extraction for Cryo-Electron Microscopy at Medium ResolutionProceedings of the 11th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics10.1145/3388440.3414711(1-9)Online publication date: 21-Sep-2020
        • (2020)A Divide and Conquer Algorithm for Electron Microscopy SegmentationProceedings of the 11th ACM International Conference on Bioinformatics, Computational Biology and Health Informatics10.1145/3388440.3414700(1-7)Online publication date: 21-Sep-2020

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