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Explainable Deep Learning for Breast Cancer Classification and Localisation

Online AM: 01 November 2024 Publication History

Abstract

Breast cancer is a kind of cancer that forms in the cells of the breasts. After skin cancer, breast cancer represents the most common cancer diagnosed in women in the United States. As a matter of fact, in January 2022, there are more than 3.8 million women with a history of breast cancer in the United States, this is the reason why there is a need for novel methods for automatic breast cancer screening, with the aim of starting any therapy as quickly as possible to try to limit the proliferation of the disease. In this paper, we propose a method aimed at detecting breast cancer through a deep learning network developed by authors. Moreover, the proposed method is able to provide prediction explainability by means of class activation mapping, aimed to automatically highlight the suspicious area on the image. We take into account a way to understand whether the cancer prediction and localisation can be considered robust by analyzing the output of two different class activation mapping algorithms. We evaluate the effectiveness of the proposed method by using a dataset composed of 9016 images obtaining an accuracy equal to 93.5%, thus showing the effectiveness of the proposed network for breast cancer detection and localisation.

References

[1]
Abunasser, B.S., AL-Hiealy, M.R.J., Zaqout, I.S., Abu-Naser, S.S., 2022. Breast cancer detection and classification using deep learning xception algorithm. International Journal of Advanced Computer Science and Applications 13. https://doi.org/10.14569/IJACSA.2022.0130729.
[2]
Balkenende, L., Teuwen, J., Mann, R.M., 2022. Application of deep learning in breast cancer imaging, in: Seminars in Nuclear Medicine, Elsevier. https://doi.org/10.1053/j.semnuclmed.2022.02.003.
[3]
Cao, Z., Duan, L., Yang, G., Yue, T., Chen, Q., 2019. An experimental study on breast lesion detection and classification from ultrasound images using deep learning architectures. BMC medical imaging 19, 1–9. http://dx.doi.org/10.1186/s12880-019-0349-x.
[4]
Debien, V., De Caluwé, A., Wang, X., Piccart-Gebhart, M., Tuohy, V.K., Romano, E., Buisseret, L., 2023. Immunotherapy in breast cancer: an overview of current strategies and perspectives. NPJ Breast Cancer 9, 7. https://doi.org/10.1038/s41523-023-00508-3.
[5]
Di Giammarco, M., Iadarola, G., Martinelli, F., Mercaldo, F., Santone, A., 2022. Explainable retinopathy diagnosis and localisation by means of class activation mapping, in: 2022 International Joint Conference on Neural Networks (IJCNN), IEEE. pp. 1–8. http://dx.doi.org/10.1109/IJCNN55064.2022.9891978.
[6]
Di Giammarco, M., Mercaldo, F., Zhou, X., Huang, P., Santone, A., Cesarelli, M., Martinelli, F., 2023. A robust and explainable deep learning method for cervical cancer screening, in: International Conference on Applied Intelligence and Informatics, Springer. pp. 111–125.
[7]
Fujioka, T., Kubota, K., Mori, M., Kikuchi, Y., Katsuta, L., Kasahara, M., Oda, G., Ishiba, T., Nakagawa, T., Tateishi, U., 2019. Distinction between benign and malignant breast masses at breast ultrasound using deep learning method with convolutional neural network. Japanese journal of radiology 37, 466–472. http://dx.doi.org/10.1007/s11604-019-00831-5.
[8]
Goodfellow, I.J., Shlens, J., Szegedy, C., 2014. Explaining and harnessing adversarial examples. arXiv preprint arXiv:1412.6572.
[9]
Han, S., Kang, H.K., Jeong, J.Y., Park, M.H., Kim, W., Bang, W.C., Seong, Y.K., 2017. A deep learning framework for supporting the classification of breast lesions in ultrasound images. Physics in Medicine & Biology 62, 7714. https://doi.org/10.1088/1361-6560/aa82ec.
[10]
Hijab, A., Rushdi, M.A., Gomaa, M.M., Eldeib, A., 2019. Breast cancer classification in ultrasound images using transfer learning, in: 2019 Fifth international conference on advances in biomedical engineering (ICABME), IEEE. pp. 1–4. https://doi.org/10.1109/ICABME47164.2019.8940291.
[11]
Hossain, A.A., Nisha, J.K., Johora, F.,. Breast cancer classification from ultrasound images using vgg16 model based transfer learning https://doi.org/10.5815/ijigsp.2023.01.02.
[12]
Huang, P., Li, C., He, P., Xiao, H., Ping, Y., Feng, P., Tian, S., Chen, H., Mercaldo, F., Santone, A., et al., 2024. Mamlformer: Priori-experience guiding transformer network via manifold adversarial multi-modal learning for laryngeal histopathological grading. Information Fusion 108, 102333.
[13]
Karthik, S., Srinivasa Perumal, R., Chandra Mouli, P., 2018. Breast cancer classification using deep neural networks. Knowledge Computing and Its Applications: Knowledge Manipulation and Processing Techniques: Volume 1, 227–241 http://dx.doi.org/10.1007/978-981-10-6680-1_12.
[14]
Krizhevsky, A., Sutskever, I., Hinton, G.E., 2012. Imagenet classification with deep convolutional neural networks. Advances in neural information processing systems 25.
[15]
Latif, G., Butt, M.O., Al Anezi, F.Y., Alghazo, J., 2020. Ultrasound image despeckling and detection of breast cancer using deep cnn, in: 2020 RIVF International Conference on Computing and Communication Technologies (RIVF), IEEE. pp. 1–5. https://doi.org/10.1109/RIVF48685.2020.9140767.
[16]
Li, Y., Wang, C., Huang, T., Yu, X., Tian, B., 2023. The role of cancer-associated fibroblasts in breast cancer metastasis. Frontiers in Oncology 13, 1194835. https://doi.org/10.3389/fonc.2023.1194835.
[17]
Masud, M., Eldin Rashed, A.E., Hossain, M.S., 2020. Convolutional neural network-based models for diagnosis of breast cancer. Neural Computing and Applications, 1–12 http://dx.doi.org/10.1007/s00521-020-05394-5.
[18]
Mercaldo, F., Ciaramella, G., Iadarola, G., Storto, M., Martinelli, F., Santone, A., 2022. Towards explainable quantum machine learning for mobile malware detection and classification. Applied Sciences 12, 12025.
[19]
Nolan, E., Lindeman, G.J., Visvader, J.E., 2023. Deciphering breast cancer: from biology to the clinic. Cell https://doi.org/10.1016/j.cell.2023.01.040.
[20]
Selvaraju, R.R., Cogswell, M., Das, A., Vedantam, R., Parikh, D., Batra, D., 2017. Grad-cam: Visual explanations from deep networks via gradient-based localization, in: Proceedings of the IEEE international conference on computer vision, pp. 618–626. http://dx.doi.org/10.1109/ICCV.2017.74.
[21]
Shah, S.M., Khan, R.A., Arif, S., Sajid, U., 2022. Artificial intelligence for breast cancer analysis: Trends & directions. Computers in Biology and Medicine 142, 105221. https://doi.org/10.1016/j.compbiomed.2022.105221.
[22]
Simonyan, K., Zisserman, A., 2014. Very deep convolutional networks for large-scale image recognition. arXiv preprint arXiv:1409.1556.
[23]
Wang, H., Wang, Z., Du, M., Yang, F., Zhang, Z., Ding, S., Mardziel, P., Hu, X., 2020. Score-cam: Score-weighted visual explanations for convolutional neural networks, in: Proceedings of the IEEE/CVF conference on computer vision and pattern recognition workshops, pp. 24–25. http://dx.doi.org/10.1109/CVPRW50498.2020.00020.
[24]
Zhang, X., Li, H., Wang, C., Cheng, W., Zhu, Y., Li, D., Jing, H., Li, S., Hou, J., Li, J., et al., 2021. Evaluating the accuracy of breast cancer and molecular subtype diagnosis by ultrasound image deep learning model. Frontiers in oncology 11, 623506. https://doi.org/10.3389/fonc.2021.623506.
[25]
Zourhri, M., Hamida, S., Akouz, N., Cherradi, B., Nhaila, H., El Khaili, M., 2023. Deep learning technique for classification of breast cancer using ultrasound images, in: 2023 3rd International Conference on Innovative Research in Applied Science, Engineering and Technology (IRASET), IEEE. pp. 1–8. https://doi.org/10.1109/IRASET57153.2023.10153069.

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cover image ACM Transactions on Computing for Healthcare
ACM Transactions on Computing for Healthcare Just Accepted
EISSN:2637-8051
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Association for Computing Machinery

New York, NY, United States

Publication History

Online AM: 01 November 2024
Accepted: 15 October 2024
Revised: 02 October 2024
Received: 21 December 2023

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Author Tags

  1. Deep Learning
  2. Breast
  3. Cancer
  4. Explainability
  5. Classification

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