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Predicting the effects of gene deletion

Published: 01 December 2002 Publication History

Abstract

In this paper, we describe techniques that can be used to predict the effects of gene deletion. We will focus mainly on the creation of predictive variables, and then briefly discuss different modeling techniques that have been used successfully on this data.

References

[1]
Saccharomyces Genome Deletion Project web page, the list of essential ORFs link: http://www-sequence.stanford.edu/group/yeast_deletion_project/Essential_ORFs.txt
[2]
Functional Profiling of the Saccharomyces cerevisiae Genome. Nature 418: 387--391 (2002).
[3]
Winzeler, E., Shoemaker, D., Astromoff, A. Liang, H., et al. Functional Characterization of the Saccharomyces cerevisiae Genome by Gene Deletion and Parallel Analysis. Science. 285, 901--906. (1999).
[4]
Shoemaker, D., Lashkari, D.A., Morris, D., Mittmann, M. & Davis, R.W. Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar-coding strategy. Nature Genetics. 14, 450--456 (1996).

Cited By

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  • (2009)A Mathematical Model for Optimal Functional Disruption of Biochemical NetworksJournal of Mathematical Modelling and Algorithms10.1007/s10852-009-9118-09:1(19-37)Online publication date: 7-Nov-2009
  • (2008)Textual information for predicting functional properties of the genesProceedings of the Workshop on Current Trends in Biomedical Natural Language Processing10.5555/1572306.1572334(110-111)Online publication date: 19-Jun-2008
  • (2004)Predicting co-complexed protein pairs using genomic and proteomic data integrationBMC Bioinformatics10.1186/1471-2105-5-385:1Online publication date: 16-Apr-2004
  • Show More Cited By

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Published In

cover image ACM SIGKDD Explorations Newsletter
ACM SIGKDD Explorations Newsletter  Volume 4, Issue 2
December 2002
127 pages
ISSN:1931-0145
EISSN:1931-0153
DOI:10.1145/772862
Issue’s Table of Contents

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Association for Computing Machinery

New York, NY, United States

Publication History

Published: 01 December 2002
Published in SIGKDD Volume 4, Issue 2

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Author Tags

  1. KDD
  2. KDD Cup
  3. decision tree
  4. deletion
  5. essential
  6. gene
  7. interaction
  8. model
  9. prediction
  10. text mining

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Cited By

View all
  • (2009)A Mathematical Model for Optimal Functional Disruption of Biochemical NetworksJournal of Mathematical Modelling and Algorithms10.1007/s10852-009-9118-09:1(19-37)Online publication date: 7-Nov-2009
  • (2008)Textual information for predicting functional properties of the genesProceedings of the Workshop on Current Trends in Biomedical Natural Language Processing10.5555/1572306.1572334(110-111)Online publication date: 19-Jun-2008
  • (2004)Predicting co-complexed protein pairs using genomic and proteomic data integrationBMC Bioinformatics10.1186/1471-2105-5-385:1Online publication date: 16-Apr-2004
  • (2004)Multi-Relational Learning, Text Mining, and Semi-Supervised Learning for Functional GenomicsMachine Language10.1023/B:MACH.0000035472.73496.0c57:1-2(61-81)Online publication date: 1-Oct-2004

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