The reference model estimates medical practice improvement in diabetic populations
Article No.: 2, Pages 1 - 12
Abstract
The Reference Model for disease progression is a league of disease models that validates simulation results to multiple observed clinical study results. Recent advances allows merging models, that were extracted from different populations in different decades, to be combined into one ensemble model that better validates against different clinical trials across years. Since each model and validation data set has a timestamp, it is possible to account for medical practice improvement during modeling. In the past it was observed that medical practice improvement caused models to become outdated and that adding temporal correction improved model fitness. However, it was unclear how much of the improvement is from prevention and how much from post event treatment. In this paper the rate of medical practice improvement is calculated through optimizing the model mixture considering diabetic populations. Results suggest similar improvement rates for prevention and post event treatment considering accumulated knowledge.
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Published: 23 April 2017
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