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Inositol trisphosphate, a novel second messenger in cellular signal transduction

Nature volume 312, pages 315–321 (1984)Cite this article

Abstract

There has recently been rapid progress in understanding receptors that generate intracellular signals from inositol lipids. One of these lipids, phosphatidylinositol 4,5-bisphosphate, is hydrolysed to diacylglycerol and inositol trisphosphate as part of a signal transduction mechanism for controlling a variety of cellular processes including secretion, metabolism, phototransduction and cell proliferation. Diacylglycerol operates within the plane of the membrane to activate protein kinase C, whereas inositol trisphosphate is released into the cytoplasm to function as a second messenger for mobilizing intracellular calcium.

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  1. AFRC Unit of Insect Neurophysiology and Pharmacology, Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, UK

    Michael J. Berridge

  2. Department of Biochemistry, AFRC Institute of Animal Physiology, Babraham, Cambridge, CB2 4AT, UK

    Robin F. Irvine

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Berridge, M., Irvine, R. Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature 312, 315–321 (1984). https://doi.org/10.1038/312315a0

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