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Using cryo-electron microscopy, the structures of mammalian fatty acid synthase reveal how the acyl carrier protein dynamically shuttles intermediates between selected active sites.
DNA double-strand breaks induce local genome maintenance and inhibition of replication initiation at nearby topologically associating domains without affecting global DNA synthesis.
We show the evolution of a case of EGFR mutant lung cancer treated with a combination of erlotinib, osimertinib, radiotherapy and a personalized neopeptide vaccine targeting somatic mutations, including EGFR exon 19 deletion.
A state-of-the-art generative artificial intelligence model of a video game is introduced to allow the support of human creative ideation, with the analysis of user study data highlighting three necessary capabilities, namely, consistency, diversity and persistency.
In a phase 1 trial, patients with pancreatic ductal adenocarcinoma who were treated with surgery and bespoke neoantigen mRNA vaccines combined with anti-PD-L1 and chemotherapy exhibited marked long-lived persistence of neoantigen-specific CD8+ T cell clones, which correlated with prolonged recurrence-free survival at a 3.2-year follow-up.
A study describes the design of de novo ligand-binding transmembrane proteins, demonstrating their specific binding and activation of fluorogenic ligands.
Reactions of Mg-rich silicates with calcium carbonates/sulfates result in the formation of materials that could potentially be used for low-cost carbon dioxide removal from the atmosphere.
A new optical technique, modulated ringdown comb interferometry, is introduced for measuring the concentration of gas species in a complex sample and its efficacy demonstrated using exhaled human breath and ambient air in the mid-infrared.
A biochemical system recapitulates the hallmarks of meiotic double-strand break formation, with mouse SPO11 catalysing break formation in the absence of any partners and remaining covalently attached to 5â²âbroken strands.
A device architecture based on indium arsenideâaluminium heterostructures with a gate-defined superconducting nanowire allows single-shot interferometric measurement of fermion parity and demonstrates an assignment error probability of 1%.
