Abstract
In the absence of cut gene activity in Drosophila, external sensory organs are transformed into chordotonal organs. Here we show that the cut locus encodes a large protein containing a homoeodomain and is expressed in nuclei of cells in external sensory organs but not in cells within chordotonal organs.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Bate, C. M. in Handbook of Sensory Physiology Vo. IX (ed. Jacobson, M.) 1â53 (Springer, Berlin, Heidelberg, New York, 1978).
Campos-Ortega, J. A. & Hartenstein, V. in The Embryonic Development of Drosophiia melanogaster (Springer, Berlin, Heidelberg, New York, 1985).
Darably-Chaudiere, C. & Ghysen, A. Wilhelm Roux Arch. dev. Biol. 195, 222â228 (1986).
Ghysen, A., Dambly-Chaudiere, C., Aceves, E., Jan, L. Y. & Jan, Y. N. Wilhelm Roux Arch. dev. Biol. 195, 281â289 (1986).
Bodmer, R. & Jan, Y. N. Wilhelm Roux Arch. dev. Biol. 196, 69â77 (1987).
Hertweck, H. Z. wiss. Zool. 139, 559â663 (1931).
Zacharuk, R. Y. in Comprehensive Insect Physiology, Biochemistry and Pharmacology Vol. 6 (eds Gilbert, L. I. & Kerkut, G. A.) 1â69 (Pergamon, New York, 1985).
McIver, S. B. in Comprehensive Insect Physiology, Biochemistry and Pharmacology Vol. 6 (eds Gilbert, L. I. & Kerkut, G. A.) 71â132 (Pergamon, New York, 1985).
Hartenstein, V. Development (in the press).
Bodmer, R. et al. Cell 51, 293â307 (1987).
Gehring, W. J. Science 236, 1245â1252 (1987).
Scott, M. P. & Carroll, S. B. Cell 51, 689â698 (1987).
Desplan, C., Theis, J. & O'Farrell, P. H. Nature 318, 630â635 (1985).
Hoey, T. & Levine, M. Nature (in the press).
Johnson, T. K. & Judd, B. H. Genetics 92, 485â502 (1979).
Jack, J. W. Cell 42, 869â876 (1985).
Cavener, D. R. Nucleic Acids Res. 15, 1353â1361 (1987).
Patel, R. S., Odermatt, E., Schwarzbauer, J. E. & Hynes, R. O. EMBO J. 6, 2565â2572 (1987).
Kornberg, T., Siden, I., O'Farrell, P. H. & Simon, M. Cell 40, 45â53 (1985).
Regulski, M., McGinnis, N., Chadwick, R. & McGinnis, W. EMBO J. 6, 767â777 (1987).
Kassis, J. A., Poole, S. J., Wright, D. K. & O'Farrell, P. H. EMBO J. 5, 3583â3589 (1986).
Guarente, L. Cell 52, 303â305 (1988).
Zipursky, S. L., Ventakesh, T. R., Teplow, D. B. & Benzer, S. Cell 36, 15â26 (1984).
Pollack, J. A. Calif. Inst. Tech. Biol. A. Rep. 203, 203 (1985).
Jan, Y. N., Ghysen, A., Christoph, I., Barbel, S. & Jan, L. Y. J. Neurosci. 5, 2453â2464 (1985).
Harris, W. A., Stark, W. S. & Walker, J. A. J. Physiol., Lond. 256, 415â439 (1976).
Campos-Ortega, J. A., Jurgens, G. & Hofbauer, A. Wilhelm Roux Arch. EntwMech Org. 186, 27â50 (1979).
Tomlinson, A. & Ready, D. F. Devl Biol. 123, 264â275 (1987).
Hafen, E., Basler, K., Edstroem, J. E. & Rubin, G. M. Science 236, 55â63 (1987).
Banerjee, U., Renfranz, P. J., Pollock, J. A. & Benzer, S. Cell 49, 281â291 (1987).
Tomlinson, A., Bowtell, D. D. L., Hafen, E. & Rubin, G. M. Cell 51, 143â150 (1987).
Banerjee, U., Renfranz, P. J., Hinton, D. R., Rabin, B. A. & Benzer, S. Cell 51, 151â158 (1987).
DiNardo, S., Kuner, J. M., Theis, J. & O'Farrell, P. H. Cell 43, 59â69 (1985).
Garcio-Bellido, A. Am. Zool. 17, 613â629 (1977).
Scott, M. P. & O'Farrell, P. H. A. Rev. Cell Biol. 2, 49â80 (1986).
Doe, C. Q., Hiromi, Y., Gehring, W. J. & Goodman, C. S. Science 239, 170â175 (1988).
Way, J. & Chalfle, M. Cell (in the press).
Awgulewitsch, A., Utset, M. F., Hart, C. P., McGinnis, W. & Ruddle, F. H. Nature 320, 328â335 (1986).
Simeone, A. et al. Nature 320, 763â765 (1986).
Carrasco, A. E. & Malacinski, G. M. Devi Biol. 121, 69â81 (1987).
Joyner, A. L. & Martin, G. R. Genes Dev. 1, 29â38 (1987).
Odenwald, W. F. Genes Dev. 1, 482â496 (1987).
Poole, S. J., Kauvar, L. M., Drees, B. & Kornberg, T. Cell 40, 37â43 (1985).
Nolan, J. M., Maxwell, P. L., Wyckoff, E. & Hsieh, T. Proc. natn. Acad. Sci. U.S.A. 83, 3664â3668 (1986).
Papazian, D. M., Schwarz, T. L., Tempel, B. L., Jan, Y. N. & Jan, L. Y. Science 237, 749â757 (1987).
Schwarz, T. L., Tempel, B. L., Papazian, D. M., Jan, Y. N. & Jan, L. Y. Nature 331, 137â142 (1988).
Sanger, F., Nicklen, S. & Coulson, A. R. Proc. natn. Acad. Sci. U.S.A. 74, 5463â5467 (1977).
Schneuwly, S., Kuroiwa, A., Baumgartner, P. & Gehring, W. J. EMBO J. 5, 733â739 (1986).
Bopp, D., Burri, M., Baumganner, S., Frigerio, G. & Noll, M. Cell 47, 1033â1040 (1986).
Newman, G. R., Jasani, B. & Williams, E. D. Microscopy 132, RP1âRP2 (1983).
O'Kane, C. J. & Gehring W. J. Proc. natn. Acad. Sci. U.S.A. 84, 9123â9127 (1987).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Blochlinger, K., Bodmer, R., Jack, J. et al. Primary structure and expression of a product from cut, a locus involved in specifying sensory organ identity in Drosophila. Nature 333, 629â635 (1988). https://doi.org/10.1038/333629a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/333629a0