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Male development of chromosomally female mice transgenic for Sry

Nature volume 351, pages 117–121 (1991)Cite this article

Abstract

The initiation of male development in mammals requires one or more genes on the Y chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many of the genetic and biological properties expected of a Y-located testis-determining gene. It is now shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos.

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References

  1. McLaren, A. Trends Genet. 4, 153–157 (1988).

    Article  CAS  Google Scholar 

  2. McLaren, A. Phil. Trans. R. Soc. 322, 3–9 (1988).

    Article  CAS  Google Scholar 

  3. Jacobs, P. A. & Strong, J. A. Nature 183, 302–303 (1959).

    Article  ADS  CAS  Google Scholar 

  4. Ford, C. E. et al. Lancet i, 711–713 (1959).

    Article  Google Scholar 

  5. Welshons, W. J. & Russell, L. B. Proc. natn. Acad. Sci. U.S.A. 45, 560–566 (1959).

    Article  ADS  CAS  Google Scholar 

  6. Jost, A. Archs. Anat. microsc. Morph. exp. 36, 271–315 (1947)

    Google Scholar 

  7. Jost, A. et al. Recent Prog. Horm. Res. 29, 1–41 (1973).

    CAS  Google Scholar 

  8. Sinclair, A. H. et al. Nature 346, 240–244 (1990).

    Article  ADS  CAS  Google Scholar 

  9. Gubbay, J. et al. Nature 346, 245–250 (1990).

    Article  ADS  CAS  Google Scholar 

  10. Lovell-Badge, R. H. & Robertson, E. Development 109, 635–646 (1990).

    CAS  Google Scholar 

  11. Gubbay, J. et al. Development 109, 647–653 (1990).

    CAS  Google Scholar 

  12. Koopman, P. et al. Nature 348, 450–452 (1990).

    Article  ADS  CAS  Google Scholar 

  13. Berta, P. et al. Nature 348, 448–450 (1990).

    Article  ADS  CAS  Google Scholar 

  14. Jäger, R. et al Nature 348, 452–454 (1990).

    Article  ADS  Google Scholar 

  15. Jost, A. & Magre, S. Phil. Trans. R. Soc. 322, 55–61 (1988).

    Article  CAS  Google Scholar 

  16. Eicher, E. M. Phil. Trans. R. Soc. 322, 109–118 (1988).

    Article  CAS  Google Scholar 

  17. Eicher, E. M. et al. Cytogenet. Cell Genet. 28, 104–115 (1980).

    Article  CAS  Google Scholar 

  18. Burgoyne, P. S., Tam, P. P. L. & Evans, E. P. J. Reprod. Fert. 68, 387–393 (1983).

    Article  CAS  Google Scholar 

  19. Mardon, G. et al. Science 243, 78–80 (1989).

    Article  ADS  CAS  Google Scholar 

  20. Nagamine, C. M. et al. Science 243, 80–83 (1989).

    Article  ADS  CAS  Google Scholar 

  21. Koopman, P. et al. Nature 342, 940–942 (1989).

    Article  ADS  CAS  Google Scholar 

  22. Cattanach, B. M., Pollard, C. E. & Hawkes, S. G. Cytogenetics 10, 318–337 (1971).

    Article  CAS  Google Scholar 

  23. Burgoyne, P. S., Levy, E. R. & McLaren, A. Nature 320, 170–172 (1986).

    Article  ADS  CAS  Google Scholar 

  24. Sutcliffe, M. J. & Burgoyne, P. S. Development 107, 373–380 (1989).

    CAS  PubMed  Google Scholar 

  25. Josso, N. in Mechanisms of Sex Differentiation in Animals and Man (eds Austin, C. R. & Edwards, R. G.) 165–203 (Academic, London, 1981).

    Google Scholar 

  26. Burgoyne, P. S. et al. Development 102, 443–450 (1988).

    CAS  PubMed  Google Scholar 

  27. Palmer, S. J. & Burgoyne, P. S. Development 111, 1017–1020 (1991).

    CAS  PubMed  Google Scholar 

  28. Grosveld, F. et al. Cell 51, 975–985 (1987).

    Article  CAS  Google Scholar 

  29. Ellis, N. A. et al. Nature 337, 81–84 (1989).

    Article  ADS  CAS  Google Scholar 

  30. Palmer, M. S. et al. Nature 342, 937–939 (1989).

    Article  ADS  CAS  Google Scholar 

  31. Jäger, R. J. et al. Hum. Genet. 85, 666–668 (1990).

    Article  Google Scholar 

  32. McLaren, A. & Monk, M. Nature 300, 446–448 (1982).

    Article  ADS  CAS  Google Scholar 

  33. Scherer, G. et al. Hum. Genet. 81, 291–294 (1989).

    CAS  PubMed  Google Scholar 

  34. Fredga, K. Phil. Trans. R. Soc. 322, 83–95 (1988).

    Article  CAS  Google Scholar 

  35. Russell, L. B., in Chemical Mutagens. Principles and Methods for their Detection Vol. 4 (ed. Hollaender, A.) 55–91 (Plenum, New York, London, 1976).

    Google Scholar 

  36. Lovell-Badge, R. H., in Teratocarcinomas and Embryonic Stem Stem Cells: A Practical Approach (ed. Robertson, E. J.) 153–182 (IRL, Oxford, 1987).

    Google Scholar 

  37. Maniatis, T., Fritsch, E. F. & Sambrook, J., eds., Molecular Cloning (Cold Spring Harbor Laboratory, New York, 1982).

  38. Hogan, B., Costantini, F. & Lacy, E., eds., Manipulating the Mouse Embryo (Cold Spring Harbor Laboratory, New York, 1986).

  39. Ashworth, A. et al. EMBO J. 9, 1529–1534 (1990).

    Article  CAS  Google Scholar 

  40. Bishop, C. E. et al. Nature 315, 70–72 (1985).

    Article  ADS  CAS  Google Scholar 

  41. Roberts, C. et al. Proc. natn. Acad. Sci. U.S.A. 85, 6646–6649 (1988).

    Google Scholar 

  42. Wright, W. E., Sassoon, D. A. & Lin, V. K. Cell 56, 607–617 (1989).

    Article  CAS  Google Scholar 

Download references

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Author notes

  1. Peter Goodfellow: Human Molecular Genetics Laboratory, Imperial Cancer Research Fund, PO Box 123, Lincoln's Inn Fields, London WC2A 3PX, UK

Authors and Affiliations

  1. Laboratory of Eukaryotic Molecular Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK

    Peter Koopman, John Gubbay, Nigel Vivian, Peter Goodfellow & Robin Lovell-Badge

Authors
  1. Peter Koopman
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  2. John Gubbay
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  3. Nigel Vivian
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  4. Peter Goodfellow
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  5. Robin Lovell-Badge
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Koopman, P., Gubbay, J., Vivian, N. et al. Male development of chromosomally female mice transgenic for Sry. Nature 351, 117–121 (1991). https://doi.org/10.1038/351117a0

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