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From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior

Nature Neuroscience volume 15, pages 1350–1355 (2012)Cite this article

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Abstract

Over the past two centuries, prevalent models of energy and glucose homeostasis have emerged from careful anatomical descriptions in tandem with an understanding of cellular physiology. More recent technological advances have culminated in the identification of peripheral and central factors that influence neural circuits regulating metabolism. This Review highlights contributions to our understanding of peripheral and central factors regulating food intake and energy expenditure.

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Figure 1: Central regulation of food intake and energy expenditure.

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Acknowledgements

The authors gratefully acknowledge M.M. Scott and L. Gautron for comments on the manuscript. This work was supported by the US National Institutes of Health (K01 DK087780 to K.W.W. and DK53301, MH61583, DK08876, DK081185 and DK71320 to J.K.E.) and by an award from the American Diabetes Association to J.K.E.

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  1. Department of Internal Medicine, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA

    Kevin W Williams & Joel K Elmquist

  2. Department of Pharmacology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA

    Joel K Elmquist

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Correspondence to Kevin W Williams.

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Williams, K., Elmquist, J. From neuroanatomy to behavior: central integration of peripheral signals regulating feeding behavior. Nat Neurosci 15, 1350–1355 (2012). https://doi.org/10.1038/nn.3217

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