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Neuronal activity stimulates a genetic program to rapidly generate synapses during development
In Caenorhabditis elegans, loss of the transcription factors FOS-1 and EGL-43 â orthologs of human FOS and MECOM, respectively â severely reduces presynaptic gene expression in dopaminergic neurons. These transcription factors form an activity-regulated positive feedback loop, which modulates the expression of synaptic genes and genetic programs to promote synapse formation.
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Orexin neurons mediate temptation-resistant voluntary exercise
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An amygdala-to-hypothalamus circuit for social reward
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Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimerâs disease model mice
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Nested compressed co-representations of multiple sequential experiences during sleep