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Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product

Nature volume 287, pages 198–203 (1980)Cite this article

Abstract

The transforming gene (src) of avian sarcoma virus (ASV) and adjacent regions of the viral genome have been isolated by molecular cloning of viral DNA. Their nucleotide sequence encompasses the whole of src and the portion of the gene env that encodes gp 37, one of two glycoproteins found in the viral envelope. Src encodes a single, hydrophobic protein with structural features that conform to previous descriptions of the gene product (pp60src). It appears that a single viral protein is responsible for both the initiation and maintenance of neoplastic transformation by avian sarcoma virus. Neither src nor its product bear any obvious structural relationship to several other viral oncogenes and their encoded proteins. Src is flanked by a repeated nucleotide sequence that may facilitate frequent deletion of the gene from the viral genome.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, University of California, San Francisco, California, 94143

    A. P. Czernilofsky, A. D. Levinson, H. E. Varmus & J. M. Bishop

  2. The Howard Hughes Medical Institute Laboratories, Department of Biochemistry and Biophysics, University of California, San Francisco, California, 94143

    E. Tischer & H. M. Goodman

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  1. A. P. Czernilofsky
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  2. A. D. Levinson
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  5. E. Tischer
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  6. H. M. Goodman
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Czernilofsky, A., Levinson, A., Varmus, H. et al. Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product. Nature 287, 198–203 (1980). https://doi.org/10.1038/287198a0

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