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Coronary artery calcification is an important indicator of coronary disease. Accurate volume quantification of coronary calcification using computed tomography (CT) is challenging due to calcium blooming. In this study, ex-vivo coronary specimens were scanned on an investigational photon-counting detector (PCD) CT scanner and the estimated coronary calcification volume were compared with a conventional energy-integrating detector (EID) CT. An image-based denoising algorithm was applied to the PCD-CT images to achieve similar noise levels as EID-CT. Calcifications were segmented to estimate the volume, with micro-CT images of the same calcifications serving as reference. PCD-CT images showed reduced calcium blooming artifacts.
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Patrick D. VanMeter, Jeffery Marsh Jr., Kishore Rajendran, Shuai Leng, Cynthia McCollough, "Quantification of coronary calcification using high-resolution photon-counting-detector CT and an image domain denoising algorithm," Proc. SPIE 12031, Medical Imaging 2022: Physics of Medical Imaging, 120311R (4 April 2022); https://doi.org/10.1117/12.2612999