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Binary particle swarm optimization based prediction of G-protein-coupled receptor families with feature selection

Published: 12 June 2009 Publication History

Abstract

G-protein-coupled receptors (GPCRs), the largest family of membrane protein, play an important role in production of therapeutic drugs. The functions of GPCRs are closely correlated with their families. It is crucial to develop powerful tools to predict GPCRs families. In this study, Binary particle swarm optimization (BPSO) algorithm, which has a better optimization performance on discrete binary variables than particle swarm optimization (PSO), is applied to extract effective feature for amino acids pair compositions of GPCRs protein sequence. Ensemble classifier is used as prediction engine, of which the basic classifier is the fuzzy K-nearest neighbor (FKNN). Each basic classifier is trained with different feature sets. The results obtained by jackknife test are quite encouraging, indicating that the proposed method might become a potentially useful tool for GPCR prediction, or play a complimentary role to the existing methods in the relevant areas.

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Cited By

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  • (2021)Overview on Binary Optimization Using Swarm-Inspired AlgorithmsIEEE Access10.1109/ACCESS.2021.31247109(149814-149858)Online publication date: 2021
  • (2018)Prediction of G-protein coupled receptors and their subfamilies by incorporating various sequence features into Chou's general PseAACComputer Methods and Programs in Biomedicine10.1016/j.cmpb.2016.07.004134:C(197-213)Online publication date: 29-Dec-2018
  • (2015)An Efficient Approach for the Prediction of G-Protein Coupled Receptors and Their SubfamiliesProceedings of 3rd International Conference on Advanced Computing, Networking and Informatics10.1007/978-81-322-2529-4_60(577-584)Online publication date: 3-Sep-2015
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    cover image ACM Conferences
    GEC '09: Proceedings of the first ACM/SIGEVO Summit on Genetic and Evolutionary Computation
    June 2009
    1112 pages
    ISBN:9781605583266
    DOI:10.1145/1543834
    Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

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    Published: 12 June 2009

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    Author Tags

    1. G-protein-coupled receptors
    2. binary particle swarm optimization
    3. ensemble classifier
    4. feature selection

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    View all
    • (2021)Overview on Binary Optimization Using Swarm-Inspired AlgorithmsIEEE Access10.1109/ACCESS.2021.31247109(149814-149858)Online publication date: 2021
    • (2018)Prediction of G-protein coupled receptors and their subfamilies by incorporating various sequence features into Chou's general PseAACComputer Methods and Programs in Biomedicine10.1016/j.cmpb.2016.07.004134:C(197-213)Online publication date: 29-Dec-2018
    • (2015)An Efficient Approach for the Prediction of G-Protein Coupled Receptors and Their SubfamiliesProceedings of 3rd International Conference on Advanced Computing, Networking and Informatics10.1007/978-81-322-2529-4_60(577-584)Online publication date: 3-Sep-2015
    • (2011)Identification Methods of G Protein-Coupled ReceptorsInternational Journal of Knowledge Discovery in Bioinformatics10.4018/jkdb.20111001032:4(35-52)Online publication date: 1-Oct-2011

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