research-article

An Implantable Release-on-Demand CMOS Drug Delivery SoC Using Electrothermal Activation Technique

Authors:

Hsin-Hung Liao,

Shey-Shi LuAuthors Info & Claims

ACM Journal on Emerging Technologies in Computing Systems (JETC), Volume 8, Issue 2

Article No.: 12, Pages 1 - 22

https://doi.org/10.1145/2180878.2180884

Published: 01 June 2012 Publication History

Abstract

An implantable system-on-a-chip (SoC) integrating controller/actuation circuitry and 8 individually addressable drug reservoirs is proposed for on-demand drug delivery. It is implemented by standard 0.35-μm CMOS technology and post-IC processing. The post-IC processing includes deposition of metallic membranes (200Å Pt/3000Å Ti/200Å Pt) to cap the drug reservoirs, deep dry etching to carve drug reservoirs in silicon as drug containers, and PDMS layer bonding to enlarge the drug storage. Based on electrothermal activation technique, drug releases can be precisely controlled by wireless signals. The wireless controller/actuation circuits including on-off keying (OOK) receiver, microcontroller unit, clock generator, power-on-reset circuit, and switch array are integrated on the same chip, providing patients the ability of remote drug activation and noninvasive therapy modification. Implanted by minimally invasive surgery, this SoC can be used for the precise drug dosing of localized treatment, such as the cancer therapy, or the immediate medication to some emergent diseases, such as heart attack. In vitro experimental results show that the reservoir content can be released successfully through the rupture of the membrane which is appointed by received wireless commands.

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Cited By

Alam M(2023)Nanocarrier‐Based Drug Delivery Systems using Microfluidic‐Assisted TechniquesAdvanced NanoBiomed Research10.1002/anbr.2023000413:11Online publication date: 31-Aug-2023
https://doi.org/10.1002/anbr.202300041
Silverio ASilverio LSilverio A(2020)Design of a Mixed Signal Bladder Control System with Sensor Front-End Readout and Drug Delivery Actuator based on TSMC 0.18um Technology2020 IEEE 8th R10 Humanitarian Technology Conference (R10-HTC)10.1109/R10-HTC49770.2020.9356960(1-5)Online publication date: 1-Dec-2020
https://doi.org/10.1109/R10-HTC49770.2020.9356960
Donohoe MJennings BBalasubramaniam S(2020)Deep brain drug-delivery control using vagus nerve communicationsComputer Networks: The International Journal of Computer and Telecommunications Networking10.1016/j.comnet.2020.107137171:COnline publication date: 1-Jul-2020
https://dl.acm.org/doi/10.1016/j.comnet.2020.107137
Show More Cited By

Index Terms

An Implantable Release-on-Demand CMOS Drug Delivery SoC Using Electrothermal Activation Technique
1. Hardware
  1. Integrated circuits

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Published In

cover image ACM Journal on Emerging Technologies in Computing Systems

ACM Journal on Emerging Technologies in Computing Systems Volume 8, Issue 2

Special Issue on Implantable Electronics

June 2012

94 pages

ISSN:1550-4832

EISSN:1550-4840

DOI:10.1145/2180878

Issue’s Table of Contents

Copyright © 2012 ACM.

Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

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ACM Journals for the Design of Smart and Connected Systems

Publication History

Published: 01 June 2012

Accepted: 01 July 2011

Revised: 01 July 2011

Received: 01 March 2011

Published in JETC Volume 8, Issue 2

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Cited By

Alam M(2023)Nanocarrier‐Based Drug Delivery Systems using Microfluidic‐Assisted TechniquesAdvanced NanoBiomed Research10.1002/anbr.2023000413:11Online publication date: 31-Aug-2023
https://doi.org/10.1002/anbr.202300041
Silverio ASilverio LSilverio A(2020)Design of a Mixed Signal Bladder Control System with Sensor Front-End Readout and Drug Delivery Actuator based on TSMC 0.18um Technology2020 IEEE 8th R10 Humanitarian Technology Conference (R10-HTC)10.1109/R10-HTC49770.2020.9356960(1-5)Online publication date: 1-Dec-2020
https://doi.org/10.1109/R10-HTC49770.2020.9356960
Donohoe MJennings BBalasubramaniam S(2020)Deep brain drug-delivery control using vagus nerve communicationsComputer Networks: The International Journal of Computer and Telecommunications Networking10.1016/j.comnet.2020.107137171:COnline publication date: 1-Jul-2020
https://dl.acm.org/doi/10.1016/j.comnet.2020.107137
Donohoe MJennings BBalasubramaniam S(2019)Capacity Analysis of a Peripheral Nerve Using Modulated Compound Action Potential PulsesIEEE Transactions on Communications10.1109/TCOMM.2018.287112167:1(154-164)Online publication date: Jan-2019
https://doi.org/10.1109/TCOMM.2018.2871121
Khan AErmakov ASukhorukov GHao Y(2019)Radio frequency controlled wireless drug delivery devicesApplied Physics Reviews10.1063/1.50991286:4Online publication date: 3-Oct-2019
https://doi.org/10.1063/1.5099128
Mehrabani YMirzaee RZareei ZDaryabari S(2017)A Novel High-Speed, Low-Power CNTFET-Based Inexact Full Adder Cell for Image Processing Application of Motion DetectorJournal of Circuits, Systems and Computers10.1142/S021812661750082726:05(1750082)Online publication date: May-2017
https://doi.org/10.1142/S0218126617500827
Joshi AChaudhari RJayant R(2017)On-Demand Controlled Drug DeliveryAdvances in Personalized Nanotherapeutics10.1007/978-3-319-63633-7_9(131-156)Online publication date: 10-Dec-2017
https://doi.org/10.1007/978-3-319-63633-7_9
Chen LHo YLiu TLu S(2016)Internet of Medical Things: The Next PC (Personal Care) EraSmart Sensors and Systems10.1007/978-3-319-33201-7_11(265-333)Online publication date: 17-Oct-2016
https://doi.org/10.1007/978-3-319-33201-7_11

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