Identification of gene clusters with phenotype-dependent expression with application to normal and premature ageing
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- Identification of gene clusters with phenotype-dependent expression with application to normal and premature ageing
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Phenotype-dependent coexpression gene clusters: application to normal and premature ageing
Hutchinson Gilford progeria syndrome (HGPS) is a rare genetic disease with symptoms of aging at a very early age. Its molecular basis is not entirely clear, although profound gene expression changes have been reported, and there are some known and other ...
Meta-analysis of age-related gene expression profiles identifies common signatures of aging
Motivation: Numerous microarray studies of aging have been conducted, yet given the noisy nature of gene expression changes with age, elucidating the transcriptional features of aging and how these relate to physiological, biochemical and ...
Identifying time-lagged gene clusters using gene expression data
Motivation: Analysis of gene expression data can provide insights into the time-lagged co-regulation of genes/gene clusters. However, existing methods such as the Event Method and the Edge Detection Method are inefficient as they compare only two ...
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