We propose a statistical method for uncovering gene pathways that characterize cancer heterogeneity. To incorporate knowledge of the pathways into the model, we define a set of activities of pathways from microarray gene expression data based on the ...
Background: Identification of pathways that show significant difference in activity between disease and control samples have been an interesting topic of research for over a decade. Pathways so identified serve as potential indicators of aberrations in ...
Genes and PPIs were integrated for the intensity of the pathway link change in the neuroepithelial tumors progress.Fragments of pathways in different stages of disease were transformed into a sparse matrix.The SVM prediction accuracy was 67.64% for 3 ...
Association for Computing Machinery
New York, NY, United States
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