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Effective Representation of Three-Dimension Nodules for False-Positive Reduction in Pulmonary Nodule Detection

Published: 24 August 2019 Publication History

Abstract

The convolutional neural networks (CNNs) can learn features representation from large amounts of training data, and it has achieved remarkable successes in image processing. However, due to expensive expert annotation and privacy issues, the lack of sufficient training data limits the application of CNNs, especially for 3D CNNs, in medical images.
In this paper, we decomposed a 3D sample into a set of 2D images based on a series of sequential uniformly-distributed viewpoints and used some "effective" 2D images of them to train a 2D CNN for the false-positive reduction in pulmonary nodule detection with fewer model parameters and less computational burden. The 2D images from different representative viewpoints would provide more complete and independent information than simplifying a 3D nodule into several orthogonal planes. And the non-nodules appear clearly as non-circular linear structures in the "effective" 2D images, which enable us well to distinguish nodules from false positives.
Our method was evaluated on 888 CT scans from the database of the LUNA16 challenge. Compared with other methods by using 2D CNNs, our proposed method achieves the highest competition performance metric (CPM) score in the false-positive reduction track. Compared to published work using 3D CNNs which needs significantly larger training data, our method achieves comparable performance by using only about 20% of training data.
The "effective" 2D images from representative viewpoints augment the database for training a 2D CNN and provide more crucial information of 3D nodules and would improve the performance of false-positive reduction.

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Cited By

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  • (2022)Multidimensional Deep Learning Reduces False-Positives in the Automated Detection of Cerebral Aneurysms on Time-Of-Flight Magnetic Resonance Angiography: A Multi-Center StudyFrontiers in Neurology10.3389/fneur.2021.74212612Online publication date: 18-Jan-2022

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cover image ACM Other conferences
ISICDM 2019: Proceedings of the Third International Symposium on Image Computing and Digital Medicine
August 2019
370 pages
ISBN:9781450372626
DOI:10.1145/3364836
Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than ACM must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected]

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  • Xidian University

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Association for Computing Machinery

New York, NY, United States

Publication History

Published: 24 August 2019

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Author Tags

  1. 2D convolutional neural networks
  2. Effective representation of a 3D nodule
  3. False-positive reduction

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  • (2022)Multidimensional Deep Learning Reduces False-Positives in the Automated Detection of Cerebral Aneurysms on Time-Of-Flight Magnetic Resonance Angiography: A Multi-Center StudyFrontiers in Neurology10.3389/fneur.2021.74212612Online publication date: 18-Jan-2022

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