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Conditional Generation Net for Medication Recommendation

Published: 25 April 2022 Publication History

Abstract

Medication recommendation targets to provide a proper set of medicines according to patients’ diagnoses, which is a critical task in clinics. Currently, the recommendation is manually conducted by doctors. However, for complicated cases, like patients with multiple diseases at the same time, it’s difficult to propose a considerate recommendation even for experienced doctors. This urges the emergence of automatic medication recommendation which can help treat the diagnosed diseases without causing harmful drug-drug interactions. Due to the clinical value, medication recommendation has attracted growing research interests. Existing works mainly formulate medication recommendation as a multi-label classification task to predict the set of medicines. In this paper, we propose the Conditional Generation Net (COGNet) which introduces a novel copy-or-predict mechanism to generate the set of medicines. Given a patient, the proposed model first retrieves his or her historical diagnoses and medication recommendations and mines their relationship with current diagnoses. Then in predicting each medicine, the proposed model decides whether to copy a medicine from previous recommendations or to predict a new one. This process is quite similar to the decision process of human doctors. We validate the proposed model on the public MIMIC data set, and the experimental results show that the proposed model can outperform state-of-the-art approaches.

References

[1]
Daniel Almirall, Scott N Compton, Meredith Gunlicks-Stoessel, Naihua Duan, and Susan A Murphy. 2012. Designing a pilot sequential multiple assignment randomized trial for developing an adaptive treatment strategy. Statistics in medicine 31, 17 (2012), 1887–1902.
[2]
James Atwood and Don Towsley. 2016. Diffusion-Convolutional Neural Networks. In Advances in Neural Information Processing Systems 29: Annual Conference on Neural Information Processing Systems 2016, December 5-10, 2016, Barcelona, Spain, Daniel D. Lee, Masashi Sugiyama, Ulrike von Luxburg, Isabelle Guyon, and Roman Garnett (Eds.). 1993–2001. https://proceedings.neurips.cc/paper/2016/hash/390e982518a50e280d8e2b535462ec1f-Abstract.html
[3]
Jimmy Lei Ba, Jamie Ryan Kiros, and Geoffrey E. Hinton. 2016. Layer Normalization. arxiv:1607.06450 [cs.LG]
[4]
Suman Bhoi, Mong-Li Lee, and Wynne Hsu. 2020. PREMIER: Personalized REcommendation for Medical prescrIptions from Electronic Records. CoRR abs/2008.13569(2020). arXiv:2008.13569https://arxiv.org/abs/2008.13569
[5]
Zhuo Chen, Kyle Marple, Elmer Salazar, Gopal Gupta, and Lakshman Tamil. 2016. A Physician Advisory System for Chronic Heart Failure management based on knowledge patterns. Theory Pract. Log. Program. 16, 5-6 (2016), 604–618. https://doi.org/10.1017/S1471068416000429
[6]
Edward Choi, Mohammad Taha Bahadori, Jimeng Sun, Joshua Kulas, Andy Schuetz, and Walter F. Stewart. 2016. RETAIN: An Interpretable Predictive Model for Healthcare using Reverse Time Attention Mechanism. In Advances in Neural Information Processing Systems 29: Annual Conference on Neural Information Processing Systems 2016, December 5-10, 2016, Barcelona, Spain, Daniel D. Lee, Masashi Sugiyama, Ulrike von Luxburg, Isabelle Guyon, and Roman Garnett (Eds.). 3504–3512. https://proceedings.neurips.cc/paper/2016/hash/231141b34c82aa95e48810a9d1b33a79-Abstract.html
[7]
Fan Gong, Meng Wang, Haofen Wang, Sen Wang, and Mengyue Liu. 2021. SMR: Medical Knowledge Graph Embedding for Safe Medicine Recommendation. Big Data Res. 23(2021), 100174. https://doi.org/10.1016/j.bdr.2020.100174
[8]
Meredith Gunlicks-Stoessel, Laura Mufson, Ana Westervelt, Daniel Almirall, and Susan Murphy. 2016. A pilot SMART for developing an adaptive treatment strategy for adolescent depression. Journal of Clinical Child & Adolescent Psychology 45, 4(2016), 480–494.
[9]
William L. Hamilton, Zhitao Ying, and Jure Leskovec. 2017. Inductive Representation Learning on Large Graphs. In Advances in Neural Information Processing Systems 30: Annual Conference on Neural Information Processing Systems 2017, December 4-9, 2017, Long Beach, CA, USA, Isabelle Guyon, Ulrike von Luxburg, Samy Bengio, Hanna M. Wallach, Rob Fergus, S. V. N. Vishwanathan, and Roman Garnett (Eds.). 1024–1034. https://proceedings.neurips.cc/paper/2017/hash/5dd9db5e033da9c6fb5ba83c7a7ebea9-Abstract.html
[10]
Alistair E. W. Johnson, Tom J. Pollard, Lu Shen, Li wei H. Lehman, Mengling Feng, Mohammad Mahdi Ghassemi, Benjamin Moody, Peter Szolovits, Leo Anthony Celi, and Roger G. Mark. 2016. MIMIC-III, a freely accessible critical care database. Scientific Data 3(2016).
[11]
Diederik P. Kingma and Jimmy Ba. 2015. Adam: A Method for Stochastic Optimization. In 3rd International Conference on Learning Representations, ICLR 2015, San Diego, CA, USA, May 7-9, 2015, Conference Track Proceedings, Yoshua Bengio and Yann LeCun (Eds.). http://arxiv.org/abs/1412.6980
[12]
Thomas N. Kipf and Max Welling. 2017. Semi-Supervised Classification with Graph Convolutional Networks. In 5th International Conference on Learning Representations, ICLR 2017, Toulon, France, April 24-26, 2017, Conference Track Proceedings. OpenReview.net. https://openreview.net/forum?id=SJU4ayYgl
[13]
Himabindu Lakkaraju and Cynthia Rudin. 2017. Learning Cost-Effective and Interpretable Treatment Regimes. In Proceedings of the 20th International Conference on Artificial Intelligence and Statistics, AISTATS 2017, 20-22 April 2017, Fort Lauderdale, FL, USA(Proceedings of Machine Learning Research, Vol. 54), Aarti Singh and Xiaojin (Jerry) Zhu (Eds.). PMLR, 166–175. http://proceedings.mlr.press/v54/lakkaraju17a.html
[14]
Hung Le, Truyen Tran, and Svetha Venkatesh. 2018. Dual Memory Neural Computer for Asynchronous Two-view Sequential Learning. In Proceedings of the 24th ACM SIGKDD International Conference on Knowledge Discovery & Data Mining, KDD 2018, London, UK, August 19-23, 2018, Yike Guo and Faisal Farooq (Eds.). ACM, 1637–1645. https://doi.org/10.1145/3219819.3219981
[15]
Preksha Nema, Akash Kumar Mohankumar, Mitesh M. Khapra, Balaji Vasan Srinivasan, and Balaraman Ravindran. 2019. Let’s Ask Again: Refine Network for Automatic Question Generation. In Proceedings of the 2019 Conference on Empirical Methods in Natural Language Processing and the 9th International Joint Conference on Natural Language Processing, EMNLP-IJCNLP 2019, Hong Kong, China, November 3-7, 2019, Kentaro Inui, Jing Jiang, Vincent Ng, and Xiaojun Wan (Eds.). Association for Computational Linguistics, 3312–3321. https://doi.org/10.18653/v1/D19-1326
[16]
Zhaopeng Qiu, Xian Wu, and Wei Fan. 2020. Automatic Distractor Generation for Multiple Choice Questions in Standard Tests. In COLING. International Committee on Computational Linguistics, 2096–2106.
[17]
Zhaopeng Qiu, Xian Wu, Jingyue Gao, and Wei Fan. 2021. U-BERT: Pre-training User Representations for Improved Recommendation. In AAAI. AAAI Press, 4320–4327.
[18]
Jesse Read, Bernhard Pfahringer, Geoffrey Holmes, and Eibe Frank. 2009. Classifier Chains for Multi-label Classification. In Machine Learning and Knowledge Discovery in Databases, European Conference, ECML PKDD 2009, Bled, Slovenia, September 7-11, 2009, Proceedings, Part II(Lecture Notes in Computer Science, Vol. 5782), Wray L. Buntine, Marko Grobelnik, Dunja Mladenic, and John Shawe-Taylor (Eds.). Springer, 254–269. https://doi.org/10.1007/978-3-642-04174-7_17
[19]
Junyuan Shang, Cao Xiao, Tengfei Ma, Hongyan Li, and Jimeng Sun. 2019. GAMENet: Graph Augmented MEmory Networks for Recommending Medication Combination. In The Thirty-Third AAAI Conference on Artificial Intelligence, AAAI 2019, The Thirty-First Innovative Applications of Artificial Intelligence Conference, IAAI 2019, The Ninth AAAI Symposium on Educational Advances in Artificial Intelligence, EAAI 2019, Honolulu, Hawaii, USA, January 27 - February 1, 2019. AAAI Press, 1126–1133. https://doi.org/10.1609/aaai.v33i01.33011126
[20]
Nicholas P Tatonetti, P Ye Patrick, Roxana Daneshjou, and Russ B Altman. 2012. Data-driven prediction of drug effects and interactions. Science translational medicine 4, 125 (2012), 125ra31–125ra31.
[21]
Flavian Vasile, Elena Smirnova, and Alexis Conneau. 2016. Meta-Prod2Vec: Product Embeddings Using Side-Information for Recommendation. In RecSys. ACM, 225–232.
[22]
Ashish Vaswani, Noam Shazeer, Niki Parmar, Jakob Uszkoreit, Llion Jones, Aidan N. Gomez, Lukasz Kaiser, and Illia Polosukhin. 2017. Attention is All you Need. In Advances in Neural Information Processing Systems 30: Annual Conference on Neural Information Processing Systems 2017, December 4-9, 2017, Long Beach, CA, USA, Isabelle Guyon, Ulrike von Luxburg, Samy Bengio, Hanna M. Wallach, Rob Fergus, S. V. N. Vishwanathan, and Roman Garnett (Eds.). 5998–6008. https://proceedings.neurips.cc/paper/2017/hash/3f5ee243547dee91fbd053c1c4a845aa-Abstract.html
[23]
Petar Velickovic, Guillem Cucurull, Arantxa Casanova, Adriana Romero, Pietro Liò, and Yoshua Bengio. 2018. Graph Attention Networks. In 6th International Conference on Learning Representations, ICLR 2018, Vancouver, BC, Canada, April 30 - May 3, 2018, Conference Track Proceedings. OpenReview.net. https://openreview.net/forum?id=rJXMpikCZ
[24]
Lu Wang, Wei Zhang, Xiaofeng He, and Hongyuan Zha. 2018. Supervised Reinforcement Learning with Recurrent Neural Network for Dynamic Treatment Recommendation. In Proceedings of the 24th ACM SIGKDD International Conference on Knowledge Discovery & Data Mining, KDD 2018, London, UK, August 19-23, 2018, Yike Guo and Faisal Farooq (Eds.). ACM, 2447–2456. https://doi.org/10.1145/3219819.3219961
[25]
Shanshan Wang, Pengjie Ren, Zhumin Chen, Zhaochun Ren, Jun Ma, and Maarten de Rijke. 2019. Order-free Medicine Combination Prediction with Graph Convolutional Reinforcement Learning. In Proceedings of the 28th ACM International Conference on Information and Knowledge Management, CIKM 2019, Beijing, China, November 3-7, 2019, Wenwu Zhu, Dacheng Tao, Xueqi Cheng, Peng Cui, Elke A. Rundensteiner, David Carmel, Qi He, and Jeffrey Xu Yu (Eds.). ACM, 1623–1632. https://doi.org/10.1145/3357384.3357965
[26]
Kelvin Xu, Jimmy Ba, Ryan Kiros, Kyunghyun Cho, Aaron C. Courville, Ruslan Salakhutdinov, Richard S. Zemel, and Yoshua Bengio. 2015. Show, Attend and Tell: Neural Image Caption Generation with Visual Attention. In Proceedings of the 32nd International Conference on Machine Learning, ICML 2015, Lille, France, 6-11 July 2015(JMLR Workshop and Conference Proceedings, Vol. 37), Francis R. Bach and David M. Blei (Eds.). JMLR.org, 2048–2057. http://proceedings.mlr.press/v37/xuc15.html
[27]
Chaoqi Yang, Cao Xiao, Lucas Glass, and Jimeng Sun. 2021. Change Matters: Medication Change Prediction with Recurrent Residual Networks. In Proceedings of the Thirtieth International Joint Conference on Artificial Intelligence, IJCAI 2021, Virtual Event / Montreal, Canada, 19-27 August 2021, Zhi-Hua Zhou (Ed.). ijcai.org, 3728–3734. https://doi.org/10.24963/ijcai.2021/513
[28]
Chaoqi Yang, Cao Xiao, Fenglong Ma, Lucas Glass, and Jimeng Sun. 2021. SafeDrug: Dual Molecular Graph Encoders for Safe Drug Recommendations. CoRR abs/2105.02711(2021). arXiv:2105.02711https://arxiv.org/abs/2105.02711
[29]
Yutao Zhang, Robert Chen, Jie Tang, Walter F. Stewart, and Jimeng Sun. 2017. LEAP: Learning to Prescribe Effective and Safe Treatment Combinations for Multimorbidity. In Proceedings of the 23rd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining, Halifax, NS, Canada, August 13 - 17, 2017. ACM, 1315–1324. https://doi.org/10.1145/3097983.3098109
[30]
Qingyu Zhou, Nan Yang, Furu Wei, Chuanqi Tan, Hangbo Bao, and Ming Zhou. 2017. Neural Question Generation from Text: A Preliminary Study. In NLPCC(Lecture Notes in Computer Science, Vol. 10619). Springer, 662–671.
[31]
Chenyi Zhuang and Qiang Ma. 2018. Dual Graph Convolutional Networks for Graph-Based Semi-Supervised Classification. In Proceedings of the 2018 World Wide Web Conference on World Wide Web, WWW 2018, Lyon, France, April 23-27, 2018, Pierre-Antoine Champin, Fabien Gandon, Mounia Lalmas, and Panagiotis G. Ipeirotis (Eds.). ACM, 499–508. https://doi.org/10.1145/3178876.3186116

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  • (2024)A Survey of Personalized Medicine RecommendationInternational Journal of Crowd Science10.26599/IJCS.2023.91000138:2(77-82)Online publication date: May-2024
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        cover image ACM Conferences
        WWW '22: Proceedings of the ACM Web Conference 2022
        April 2022
        3764 pages
        ISBN:9781450390965
        DOI:10.1145/3485447
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        Published: 25 April 2022

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        Author Tags

        1. electronic health record
        2. generation
        3. medication recommendation

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        April 25 - 29, 2022
        Virtual Event, Lyon, France

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        Cited By

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        • (2024)A Survey of Personalized Medicine RecommendationInternational Journal of Crowd Science10.26599/IJCS.2023.91000138:2(77-82)Online publication date: May-2024
        • (2024)Contrastive Learning on Medical Intents for Sequential Prescription RecommendationProceedings of the 33rd ACM International Conference on Information and Knowledge Management10.1145/3627673.3679836(748-757)Online publication date: 21-Oct-2024
        • (2024)CausalMed: Causality-Based Personalized Medication Recommendation Centered on Patient Health StateProceedings of the 33rd ACM International Conference on Information and Knowledge Management10.1145/3627673.3679542(1276-1285)Online publication date: 21-Oct-2024
        • (2024)Natural Language-Assisted Multi-modal Medication RecommendationProceedings of the 33rd ACM International Conference on Information and Knowledge Management10.1145/3627673.3679529(2200-2209)Online publication date: 21-Oct-2024
        • (2024)OEHR: An Orthopedic Electronic Health Record DatasetProceedings of the 47th International ACM SIGIR Conference on Research and Development in Information Retrieval10.1145/3626772.3657885(1126-1135)Online publication date: 10-Jul-2024
        • (2024)Leave No Patient Behind: Enhancing Medication Recommendation for Rare Disease PatientsProceedings of the 47th International ACM SIGIR Conference on Research and Development in Information Retrieval10.1145/3626772.3657785(533-542)Online publication date: 10-Jul-2024
        • (2024)GraphLeak: Patient Record Leakage through Gradients with Knowledge GraphProceedings of the ACM Web Conference 202410.1145/3589334.3648157(4706-4716)Online publication date: 13-May-2024
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        • (2024)Bilateral Multi-Behavior Modeling for Reciprocal Recommendation in Online RecruitmentIEEE Transactions on Knowledge and Data Engineering10.1109/TKDE.2024.339770536:11(5681-5694)Online publication date: Nov-2024
        • (2024)Enhancing Drug Recommendations Via Heterogeneous Graph Representation Learning in EHR NetworksIEEE Transactions on Knowledge and Data Engineering10.1109/TKDE.2023.332902536:7(3024-3035)Online publication date: Jul-2024
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