The Anti-tumor Effects of Ultrasonic Mechanical Force on human liver cancer cells

Malignant tumors (ie, cancer) are major public health problems in China and even in the gable wide. Since the early 1970s, the anti-tumor effects of ultrasound have been widely used in the clinical treatment of various tumors, mainly relying on the thermal effect and cavitation, both of which have unsolved problems during applications, thus the use of ultrasonic mechanical mechanisms has become a possible breakthrough. In 2008, it was reported that mechanical stress inhibited the growth of tumor cells, and ultrasound was the propagation of mechanical vibrational energy. Ultrasonic mechanical force (UMF) has following advantages of inhibiting tumor: 1. Low power. There is no damage to normal cells and surface contact skin; 2. Frequency differences between tumors. There are frequency differences between normal cells and cancer cells and between different types of cancer cells, which make ultrasonic therapy more precise. This study intended to use human liver cancer cells as experimental subjects and found out their sensitive frequency. Hepatoma cells showed a significant frequency dependence on UMF, and the changes of oxidative stress level and biological behavior were the most obvious under the action of sensitive frequency UMF at 600 kHz.