In order to solve the problem of providing the population with high-quality drinking water, preference is given to the use of groundwater deposits, which differ from surface sources in better quality and are more protected from man-made influences and climate change. Thirty-seven existing groundwater deposits are used for drinking and technical water supply in Lviv region. The distribution of groundwater in the region is very uneven, and in the Eastern Carpathians they are almost non-existent. The main factors of groundwater pollution in most of Ukraine are municipal sewage, livestock effluents, unorganized warehouses for storage of industrial waste, fertilizers and pesticides and other local objects that affect the state of groundwater. The gradual reduction of mineral fertilizer and pesticide usage has led to some improvement in the quality of groundwater, but for some agro-industrial areas the presence of residual pesticides and nitrogen compounds in groundwater remains a relevant problem. This year, there was an increase in the use of mineral fertilizers compared to last year. The aim of this work was to study the compliance of the maximum allowable concentrations of hydrochemical parameters of the wells of the Stryi water intake and to determine the potential impact of anthropogenic factors on water quality. The compliance with the sanitary and hygienic requirements of the hydrochemical parameters of water in the wells of the Stryi water intake was analyzed. The regularities of their changes as well as the presence of wells that have a potentially unstable chemical composition and are prone to deterioration of water quality were determined. The results of studies of related to the impact of self-treatment processes in the river Stryi on the quality of water intake in the city of Stryi showed that the drinking water from artesian wells is of high quality and now there are no negative effects of river water in the Stryi basin on groundwater deposits. The quality of river water is satisfactory for its use in domestic and drinking water supply and for recreational purposes.