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Model-Free Reconstruction of Excitatory Neuronal Connectivity from Calcium Imaging Signals

Figure 8

Network reconstruction of an in vitro neuronal culture at DIV 12.

A Example of TE reconstructed connectivity in a subset of 49 neurons (identified by black dots) in a culture with marked neurons (regions of interest) in the field of view, studied at day in vitro 12. Only the top 5% of connections are retained in order to achieve, in the final reconstructed network, an average connection degree of 100 (see Results). B Properties of the network inferred from TE reconstruction method (top panels) compared to a cross-correlation (XC) analysis (bottom panels). The figure shows reconstructed distributions for the in-degree (left column), the connection distance (middle column), and the clustering coefficient (right column). In addition to the actual reconstructed histograms (yellow), distributions for randomized networks are also shown. Blue color refers to complete randomizations that preserves only the total number of connections, and red color to partial randomizations that shuffle only the target connections of each neuron in the reconstructed network.

doi: https://doi.org/10.1371/journal.pcbi.1002653.g008