Lubricant Strategies in Osteoarthritis Treatment: Transitioning from Natural Lubricants to Drug Delivery Particles with Lubricant Properties
Abstract
:1. Introduction
2. Structural Components of Articular Joints
3. Articular Cartilage Lubrication Mechanism
4. The Role of Cartilage Lubrication in Osteoarthritis Pathogenesis
5. Natural Lubricants Based on HA and Its Hydrogel-Formulated Derivatives
6. Innovative Hydrogel-Based Strategies for Lubrication and Drug Delivery
- a.
- Non-HA-based Hydrogels with superior Lubricant features:
- b.
- Micro-gels and Nano-gels
Name and Microparticle Structure | Material | Size | Outcomes | Ref. |
---|---|---|---|---|
GelMA@DMA-MPC | GelMA microspheres coated with DMA-MPC and loaded with DC | 150 µm | GelMA@DMA-MPC showed enhanced lubrication and sustained drug release of DC. Injected into rat knee joints with osteoarthritis, they showed significant therapeutic effects. | [79] |
MGS@DMA-SBMA | GelMA microspherese coated with DMA-SBMA and loaded with DC | 100 µm | MGS@DMA-SBMA demonstrated improved lubrication abilities and provided chondroprotection both in vitro and in vivo in an OA rat model. | [80] |
RAPA@Lipo@HMS | RAPA-liposome– incorporating HA–based HMs | 200 µm | RAPA@Lipo@HMs enhanced joint lubrication with a smooth rolling mechanism and continuous exposure of liposomes on the surface, forming self-renewing hydration layers through friction. | [81] |
µPlate | PLGA | 20 µm | Drug depot with sustained release; mechanical support to the joint; small molecules delivery. | [82,83] |
Name and Nanoparticle Structure | Material | Size | Outcomes | Ref. |
---|---|---|---|---|
SB-g-NBrMGs | PSPMK brushes-grafted PNIPAAm microgel | ~500 nm | These hairy microgels showed notable tribological properties and temperature-triggered drug release ability. | [86] |
HA-PNIPAM | HA-grafted PNIPAM | ~200 nm | Improved injectability, sensitivity to enzymatic degradation, and cytocompatibility. Prolonged joint retention joint, cartilage protection and reduction of pro-inflammatory cytokines. | [87] |
PNIPAM-PMPC | PNIPAM PMPC | ~200 nm | Resistant to high pressure, efficient DDS for DC, able to control the thermo-sensitive drug release. | [88] |
Chitosan NP | Chitosan NP grafted with hydrophilic sulfonic acid groups. | ~160 nm | Low friction coefficient (µ = 0.01) and valuable DDS. | [89] |
PSBMA-CBPXGSB1/5 | Xanthan gum PSBMA Collagen II-Binding peptide | ~280 nm | Good lubrication proprieties. | [90] |
mega HPGs | Hyper-branched glycerol polymers | ~20–50 nm | High water solubility and low intrinsic viscosity. | [91] |
7. Innovative Liposome-Based Strategies for Drug Delivery and Lubrication
8. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
AZO | azobenzene |
CD-PMPC | β-cyclodextrin (CD)-modified poly(2-methacryloyloxyethyl phosphorylcholine) |
DC | dicolfenac |
DDS | drug delivery systems |
DEX | dexamethasone |
DMA-MPC | dopamine methacrylamide-2-methacryloyloxyethylphosphorylcholine |
DMA-SBMA-pSBMA | dopamine methacrylamide-sulfobetaine methacrylate |
DMAA | HEMA and N, N-dimethylacrylamide |
DMM | destabilization of the medial meniscus |
DMPC | 1,2-dimyristoyl-sn-glycero-3-phosphocholine |
DOPC | dioleoyl-sn-glycero-3-phosphatidylcholine |
DOPG | l,2-dioleoyl-sn-glycero-3-phosphoglycerol |
DOTAP | 1,2-DioleOyl-3-TrimethylAmmonium Propane |
DPPC | 1,2-dipalmitoyl-sn-glycero-3-phosphocholine |
DPPE | dipalmitoyl phosphatidylethanolamine |
DS | diclofenac sodium |
DSP | dexamethasone sodium phosphate |
ECM | extracellular matrix |
FDA | Food and Drug Administration |
FLS | type B fibroblast-like synoviocytes |
GAG | glycosaminoglycans |
GelMA | gelatin methacryalate |
HA | hyaluronic acid |
HA-PNIPAM | HA-poly(N-isopropylacrylamide) |
HPG | hyperbranched glycerol polymers |
HSPC | hydrogenated soy phosphatidylcholine |
IA | intra-articular |
IL | interleukin |
Liss Rhod PE | 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine |
MLS | macrophage-like synoviocytes |
MLV | multilamellar vesicles |
MMPs | matrix metalloproteinases |
MP | microparticles |
MSNs | mesoporous silica NP |
MSNs-NH2@PMPC | poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)-grafted MSNs |
MSNs-NH2@PSPMK | poly(2-methacryloyloxyethyl phosphorylcholine) (PSPMK)-grafted MSNs |
MT | mitochondria |
MW | molecular weight |
NP | nanoparticles |
NSAID | Non-Steroidal Anti-Inflammatory Drug |
OA | osteoarthritis |
OARSI | Osteoarthritis Research Society International |
PAMPS | poly-2-acrylamide-2-methylpropanesulfonic |
PE | phosphatidylEthanolamine |
PEG | poly(ethylene glycol) |
PGs | proteoglycans |
PG | prostaglandin |
pHEMA | poly(hydroxyethylmethacrylate) |
PL | phospholipids |
PLGA | Poly lactic-co-glycolic acid |
PMS | poly(2-methacryloyloxyethyl phosphorylcholine) (MPC)-co-poly(sulfobetaine methacrylate) (SBMA) hydrogel |
PMPC | poly-2-methacryloyloxyethyl phosphoryl choline |
PNIPAAm | poly(3-sulfopropyl methacrylate potassium salt) (PSPMK) brushes grafted onto poly(N-isopropylacrylamide) |
PNIPAM-PMPC PSBMA | poly[N-isopropylacrylamide-2-methacryloyloxyethyl phosphorylcholine] (PNIPAM-PMPC) |
PSBMA | poly(sulfobetaine methacrylate) |
PSPMK | poly(3-sulfopropyl methacrylate potassium salt) |
RA | rheumatoid arthritis |
RNS | Reactive Nitrogen Species |
ROS | Reactive Oxygen Species |
SB-g-NBrMGs | poly(3-sulfopropyl methacrylate potassium salt) (PSPMK) brushes grafted poly(N-isopropylacrylamide)(PNIPAAm) micro-gels |
SF | synovial fluid |
SUV | single unilamellar vesicles |
VEGF | Vascular Endothelial Growth Factor |
References
- Lin, W.; Klein, J. Recent progress in cartilage lubrication. Adv. Mater. 2021, 33, 2005513. [Google Scholar] [CrossRef] [PubMed]
- Murakami, T.; Yarimitsu, S.; Nakashima, K.; Sawae, Y.; Sakai, N. Influence of synovia constituents on tribological behaviors of articular cartilage. Friction 2013, 1, 150–162. [Google Scholar] [CrossRef]
- Martel-Pelletier, J.; Barr, A.; Cicuttini, F.; Conaghan, P.; Cooper, C.; Goldring, M.; Goldring, S.; Jones, G.; Teichtahl, A.; Pelletier, J. Osteoarthritis. Nat. Rev. Dis. Primers 2016, 2, 16072. [Google Scholar] [CrossRef] [PubMed]
- Li, Y.; Yuan, Z.; Yang, H.; Zhong, H.; Peng, W.; Xie, R. Recent advances in understanding the role of cartilage lubrication in osteoarthritis. Molecules 2021, 26, 6122. [Google Scholar] [CrossRef] [PubMed]
- Desrochers, J.; Amrein, M.W.; Matyas, J.R. Microscale surface friction of articular cartilage in early osteoarthritis. J. Mech. Behav. Biomed. Mater. 2013, 25, 11–22. [Google Scholar] [CrossRef]
- Blain, E.J.; Gilbert, S.J.; Wardale, R.J.; Capper, S.; Mason, D.J.; Duance, V.C. Up-regulation of matrix metalloproteinase expression and activation following cyclical compressive loading of articular cartilage in vitro. Arch. Biochem. Biophys. 2001, 396, 49–55. [Google Scholar] [CrossRef]
- Bonnevie, E.D.; Bonassar, L.J. A century of cartilage tribology research is informing lubrication therapies. J. Biomech. Eng. 2020, 142, 031004. [Google Scholar] [CrossRef]
- Morgese, G.; Benetti, E.M.; Zenobi-Wong, M. Molecularly engineered biolubricants for articular cartilage. Adv. Healthc. Mater. 2018, 7, 1701463. [Google Scholar] [CrossRef]
- An, H.; Liu, Y.; Yi, J.; Xie, H.; Li, C.; Wang, X.; Chai, W. Research progress of cartilage lubrication and biomimetic cartilage lubrication materials. Front. Bioeng. Biotechnol. 2022, 10, 1012653. [Google Scholar] [CrossRef]
- Yuan, H.; Mears, L.L.; Wang, Y.; Su, R.; Qi, W.; He, Z.; Valtiner, M. Lubricants for osteoarthritis treatment: From natural to bioinspired and alternative strategies. Adv. Colloid Interface Sci. 2023, 311, 102814. [Google Scholar] [CrossRef]
- Frisbie, D.; Cross, M.; McIlwraith, C. A comparative study of articular cartilage thickness in the stifle of animal species used in human pre-clinical studies compared to articular cartilage thickness in the human knee. Vet. Comp. Orthop. Traumatol. 2006, 19, 142–146. [Google Scholar] [CrossRef] [PubMed]
- Gobbi, A.; Irlandini, E.; Moorhead, A.P. Anatomy and Function of Articular Cartilage. Manag. Track Field Inj. 2022, 43–53. [Google Scholar]
- Akkiraju, H.; Nohe, A. Role of chondrocytes in cartilage formation, progression of osteoarthritis and cartilage regeneration. J. Dev. Biol. 2015, 3, 177–192. [Google Scholar] [CrossRef] [PubMed]
- Eyre, D.R.; Weis, M.A.; Wu, J.-J. Articular cartilage collagen: An irreplaceable framework. Eur. Cell Mater. 2006, 12, 57–63. [Google Scholar] [CrossRef] [PubMed]
- Kiani, C.; Chen, L.; Wu, Y.J.; Yee, A.J.; Yang, B.B. Structure and function of aggrecan. Cell Res. 2002, 12, 19–32. [Google Scholar] [CrossRef] [PubMed]
- Roughley, P.J. The structure and function of cartilage proteoglycans. Eur. Cell Mater. 2006, 12, 92–101. [Google Scholar] [CrossRef] [PubMed]
- Gupta, R.C.; Lall, R.; Srivastava, A.; Sinha, A. Hyaluronic acid: Molecular mechanisms and therapeutic trajectory. Front. Vet. Sci. 2019, 6, 458280. [Google Scholar] [CrossRef]
- Tamer, T.M. Hyaluronan and synovial joint: Function, distribution and healing. Interdiscip. Toxicol. 2013, 6, 111–125. [Google Scholar] [CrossRef]
- Fujioka, R.; Aoyama, T.; Takakuwa, T. The layered structure of the articular surface. Osteoarthr. Cartil. 2013, 21, 1092–1098. [Google Scholar] [CrossRef]
- Chang, D.P.; Guilak, F.; Jay, G.D.; Zauscher, S. Interaction of lubricin with type II collagen surfaces: Adsorption, friction, and normal forces. J. Biomech. 2014, 47, 659–666. [Google Scholar] [CrossRef]
- Halonen, K.; Mononen, M.; Jurvelin, J.; Töyräs, J.; Korhonen, R. Importance of depth-wise distribution of collagen and proteoglycans in articular cartilage—A 3D finite element study of stresses and strains in human knee joint. J. Biomech. 2013, 46, 1184–1192. [Google Scholar] [CrossRef] [PubMed]
- Sophia Fox, A.J.; Bedi, A.; Rodeo, S.A. The basic science of articular cartilage: Structure, composition, and function. Sports Health 2009, 1, 461–468. [Google Scholar] [CrossRef] [PubMed]
- Redondo, M.L.; Christian, D.R.; Yanke, A.B. The role of synovium and synovial fluid in joint hemostasis. In Joint Preservation of the Knee; Springer: Berlin/Heidelberg, Germany, 2019; pp. 57–67. Available online: https://link.springer.com/book/10.1007/978-3-030-01491-9 (accessed on 17 July 2024).
- McCarty, D.J. The physiology of the normal synovium. In The Joints and Synovial Fluid; Elsevier: Amsterdam, The Netherlands, 1980; pp. 293–314. [Google Scholar]
- Bai, L.-K.; Su, Y.-Z.; Wang, X.-X.; Bai, B.; Zhang, C.-Q.; Zhang, L.-Y.; Zhang, G.-L. Synovial macrophages: Past life, current situation, and application in inflammatory arthritis. Front. Immunol. 2022, 13, 905356. [Google Scholar] [CrossRef] [PubMed]
- Mahmoud, D.E.; Kaabachi, W.; Sassi, N.; Tarhouni, L.; Rekik, S.; Jemmali, S.; Sehli, H.; Kallel-Sellami, M.; Cheour, E.; Laadhar, L. The synovial fluid fibroblast-like synoviocyte: A long-neglected piece in the puzzle of rheumatoid arthritis pathogenesis. Front. Immunol. 2022, 13, 942417. [Google Scholar] [CrossRef]
- Forster, H.; Fisher, J. The influence of loading time and lubricant on the friction of articular cartilage. Proc. Inst. Mech. Eng. Part H J. Eng. Med. 1996, 210, 109–119. [Google Scholar] [CrossRef]
- Klein, J. Molecular mechanisms of synovial joint lubrication. Proc. Inst. Mech. Eng. Part J J. Eng. Tribol. 2006, 220, 691–710. [Google Scholar] [CrossRef]
- Jahn, S.; Seror, J.; Klein, J. Lubrication of articular cartilage. Annu. Rev. Biomed. Eng. 2016, 18, 235–258. [Google Scholar] [CrossRef]
- Gleghorn, J.P.; Bonassar, L.J. Lubrication mode analysis of articular cartilage using Stribeck surfaces. J. Biomech. 2008, 41, 1910–1918. [Google Scholar] [CrossRef]
- Greene, G.W.; Olszewska, A.; Osterberg, M.; Zhu, H.; Horn, R. A cartilage-inspired lubrication system. Soft Matter 2014, 10, 374–382. [Google Scholar] [CrossRef]
- Smith, D.W.; Gardiner, B.S.; Zhang, L.; Grodzinsky, A.J. Articular Cartilage Dynamics; Springer: Singapore, 2019. [Google Scholar]
- Li, W.; Morita, T.; Sawae, Y. Experimental study on boundary lubricity of superficial area of articular cartilage and synovial fluid. Friction 2024, 12, 981–996. [Google Scholar] [CrossRef]
- Seror, J.; Zhu, L.; Goldberg, R.; Day, A.J.; Klein, J. Supramolecular synergy in the boundary lubrication of synovial joints. Nat. Commun. 2015, 6, 6497. [Google Scholar] [CrossRef] [PubMed]
- Klein, J. Hydration lubrication. Friction 2013, 1, 1–23. [Google Scholar] [CrossRef]
- Ghosh, P.; Hutadilok, N.; Adam, N.; Lentini, A. Interactions of hyaluronan (hyaluronic acid) with phospholipids as determined by gel permeation chromatography, multi-angle laser-light-scattering photometry and 1H-NMR spectroscopy. Int. J. Biol. Macromol. 1994, 16, 237–244. [Google Scholar] [CrossRef] [PubMed]
- Jahn, S.; Klein, J. Hydration lubrication: The macromolecular domain. Macromolecules 2015, 48, 5059–5075. [Google Scholar] [CrossRef]
- Onishi, K.; Utturkar, A.; Chang, E.Y.; Panush, R.; Hata, J.; Perret-Karimi, D. Osteoarthritis: A critical review. Crit. Rev.™ Phys. Rehabil. Med. 2012, 24, 251–264. [Google Scholar] [CrossRef]
- Quicke, J.; Conaghan, P.; Corp, N.; Peat, G. Osteoarthritis year in review 2021: Epidemiology & therapy. Osteoarthr. Cartil. 2022, 30, 196–206. [Google Scholar]
- Colombo, G.L.; Heiman, F.; Peduto, I. Utilization of healthcare resources in osteoarthritis: A cost of illness analysis based on real-world data in Italy. Ther. Clin. Risk Manag. 2021, 17, 345–356. [Google Scholar] [CrossRef]
- Wehling, P.; Evans, C.; Wehling, J.; Maixner, W. Effectiveness of intra-articular therapies in osteoarthritis: A literature review. Ther. Adv. Musculoskelet. Dis. 2017, 9, 183–196. [Google Scholar] [CrossRef]
- Tong, L.; Yu, H.; Huang, X.; Shen, J.; Xiao, G.; Chen, L.; Wang, H.; Xing, L.; Chen, D. Current understanding of osteoarthritis pathogenesis and relevant new approaches. Bone Res. 2022, 10, 60. [Google Scholar] [CrossRef]
- Molnar, V.; Matišić, V.; Kodvanj, I.; Bjelica, R.; Jeleč, Ž.; Hudetz, D.; Rod, E.; Čukelj, F.; Vrdoljak, T.; Vidović, D. Cytokines and chemokines involved in osteoarthritis pathogenesis. Int. J. Mol. Sci. 2021, 22, 9208. [Google Scholar] [CrossRef]
- Kosinska, M.K.; Ludwig, T.E.; Liebisch, G.; Zhang, R.; Siebert, H.-C.; Wilhelm, J.; Kaesser, U.; Dettmeyer, R.B.; Klein, H.; Ishaque, B. Articular joint lubricants during osteoarthritis and rheumatoid arthritis display altered levels and molecular species. PLoS ONE 2015, 10, e0125192. [Google Scholar] [CrossRef] [PubMed]
- Dahl, L.; Dahl, I.; Engström-Laurent, A.; Granath, K. Concentration and molecular weight of sodium hyaluronate in synovial fluid from patients with rheumatoid arthritis and other arthropathies. Ann. Rheum. Dis. 1985, 44, 817–822. [Google Scholar] [CrossRef] [PubMed]
- Lepetsos, P.; Papavassiliou, A.G. ROS/oxidative stress signaling in osteoarthritis. Biochim. Biophys. Acta (BBA)-Mol. Basis Dis. 2016, 1862, 576–591. [Google Scholar] [CrossRef] [PubMed]
- Zhao, Z.; Li, Y.; Wang, M.; Zhao, S.; Zhao, Z.; Fang, J. Mechanotransduction pathways in the regulation of cartilage chondrocyte homoeostasis. J. Cell. Mol. Med. 2020, 24, 5408–5419. [Google Scholar] [CrossRef]
- Fitzgerald, J.B.; Jin, M.; Grodzinsky, A.J. Shear and compression differentially regulate clusters of functionally related temporal transcription patterns in cartilage tissue. J. Biol. Chem. 2006, 281, 24095–24103. [Google Scholar] [CrossRef]
- Romani, P.; Valcarcel-Jimenez, L.; Frezza, C.; Dupont, S. Crosstalk between mechanotransduction and metabolism. Nat. Rev. Mol. Cell Biol. 2021, 22, 22–38. [Google Scholar] [CrossRef]
- Grodzinsky, A.J.; Levenston, M.E.; Jin, M.; Frank, E.H. Cartilage tissue remodeling in response to mechanical forces. Annu. Rev. Biomed. Eng. 2000, 2, 691–713. [Google Scholar] [CrossRef]
- Buschmann, M.D.; Gluzband, Y.A.; Grodzinsky, A.J.; Hunziker, E.B. Mechanical compression modulates matrix biosynthesis in chondrocyte/agarose culture. J. Cell Sci. 1995, 108, 1497–1508. [Google Scholar] [CrossRef]
- Sellam, J.; Berenbaum, F. The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nat. Rev. Rheumatol. 2010, 6, 625–635. [Google Scholar] [CrossRef]
- Peck, J.; Slovek, A.; Miro, P.; Vij, N.; Traube, B.; Lee, C.; Berger, A.A.; Kassem, H.; Kaye, A.D.; Sherman, W.F. A comprehensive review of viscosupplementation in osteoarthritis of the knee. Orthop. Rev. 2021, 13, 25549. [Google Scholar] [CrossRef]
- Bowman, S.; Awad, M.E.; Hamrick, M.W.; Hunter, M.; Fulzele, S. Recent advances in hyaluronic acid based therapy for osteoarthritis. Clin. Transl. Med. 2018, 7, 6. [Google Scholar] [CrossRef] [PubMed]
- Balazs, E.A.; Denlinger, J.L. Viscosupplementation: A new concept in the treatment of osteoarthritis. J. Rheumatol. Suppl. 1993, 39, 3–9. [Google Scholar] [PubMed]
- Yasuda, T. Hyaluronan inhibits prostaglandin E2 production via CD44 in U937 human macrophages. Tohoku J. Exp. Med. 2010, 220, 229–235. [Google Scholar] [CrossRef] [PubMed]
- Sasaki, A.; Sasaki, K.; Konttinen, Y.T.; Santavirta, S.; Takahara, M.; Takei, H.; Ogino, T.; Takagi, M. Hyaluronate inhibits the interleukin-1β-induced expression of matrix metalloproteinase (MMP)-1 and MMP-3 in human synovial cells. Tohoku J. Exp. Med. 2004, 204, 99–107. [Google Scholar] [CrossRef]
- Gan, X.; Wang, X.; Huang, Y.; Li, G.; Kang, H. Applications of Hydrogels in Osteoarthritis Treatment. Biomedicines 2024, 12, 923. [Google Scholar] [CrossRef]
- Wang, C.-T.; Lin, Y.-T.; Chiang, B.-L.; Lin, Y.-H.; Hou, S.-M. High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis. Osteoarthr. Cartil. 2006, 14, 1237–1247. [Google Scholar] [CrossRef]
- MM, S. The synthesis of hyaluronic acid by human synovial fibroblast is influenced by the nature of the hyaluronate in the extracellular environment. Rheumatol Int. 1987, 7, 113–122. [Google Scholar]
- Ghosh, P.; Guidolin, D. Potential mechanism of action of intra-articular hyaluronan therapy in osteoarthritis: Are the effects molecular weight dependent? Semin. Arthritis Rheum. 2002, 32, 10–37. [Google Scholar] [CrossRef]
- Euppayo, T.; Punyapornwithaya, V.; Chomdej, S.; Ongchai, S.; Nganvongpanit, K. Effects of hyaluronic acid combined with anti-inflammatory drugs compared with hyaluronic acid alone, in clinical trials and experiments in osteoarthritis: A systematic review and meta-analysis. BMC Musculoskelet. Disord. 2017, 18, 1–14. [Google Scholar] [CrossRef]
- Zheng, Y.; Yang, J.; Liang, J.; Xu, X.; Cui, W.; Deng, L.; Zhang, H. Bioinspired hyaluronic acid/phosphorylcholine polymer with enhanced lubrication and anti-inflammation. Biomacromolecules 2019, 20, 4135–4142. [Google Scholar] [CrossRef]
- Xie, R.; Yao, H.; Mao, A.S.; Zhu, Y.; Qi, D.; Jia, Y.; Gao, M.; Chen, Y.; Wang, L.; Wang, D.-A. Biomimetic cartilage-lubricating polymers regenerate cartilage in rats with early osteoarthritis. Nat. Biomed. Eng. 2021, 5, 1189–1201. [Google Scholar] [CrossRef] [PubMed]
- Faust, H.J.; Sommerfeld, S.D.; Rathod, S.; Rittenbach, A.; Banerjee, S.R.; Tsui, B.M.; Pomper, M.; Amzel, M.L.; Singh, A.; Elisseeff, J.H. A hyaluronic acid binding peptide-polymer system for treating osteoarthritis. Biomaterials 2018, 183, 93–101. [Google Scholar] [CrossRef] [PubMed]
- Rong, M.; Liu, H.; Scaraggi, M.; Bai, Y.; Bao, L.; Ma, S.; Ma, Z.; Cai, M.; Dini, D.; Zhou, F. High lubricity meets load capacity: Cartilage mimicking bilayer structure by brushing up stiff hydrogels from subsurface. Adv. Funct. Mater. 2020, 30, 2004062. [Google Scholar] [CrossRef]
- Qu, M.; Liu, H.; Yan, C.; Ma, S.; Cai, M.; Ma, Z.; Zhou, F. Layered hydrogel with controllable surface dissociation for durable lubrication. Chem. Mater. 2020, 32, 7805–7813. [Google Scholar] [CrossRef]
- Lin, P.; Zhang, R.; Wang, X.; Cai, M.; Yang, J.; Yu, B.; Zhou, F. Articular cartilage inspired bilayer tough hydrogel prepared by interfacial modulated polymerization showing excellent combination of high load-bearing and low friction performance. ACS Macro Lett. 2016, 5, 1191–1195. [Google Scholar] [CrossRef] [PubMed]
- Zhao, W.; Zhang, Y.; Zhao, X.; Ji, Z.; Ma, Z.; Gao, X.; Ma, S.; Wang, X.; Zhou, F. Bioinspired design of a cartilage-like lubricated composite with mechanical robustness. ACS Appl. Mater. Interfaces 2022, 14, 9899–9908. [Google Scholar] [CrossRef]
- Lin, W.; Kluzek, M.; Iuster, N.; Shimoni, E.; Kampf, N.; Goldberg, R.; Klein, J. Cartilage-inspired, lipid-based boundary-lubricated hydrogels. Science 2020, 370, 335–338. [Google Scholar] [CrossRef]
- Feng, S.; Li, J.; Li, X.; Wen, S.; Liu, Y. Synergy of phospholipid and hyaluronan based super-lubricated hydrogels. Appl. Mater. Today 2022, 27, 101499. [Google Scholar] [CrossRef]
- Xiao, F.; Tang, J.; Huang, X.; Kang, W.; Zhou, G. A robust, low swelling, and lipid-lubricated hydrogel for bionic articular cartilage substitute. J. Colloid Interface Sci. 2023, 629, 467–477. [Google Scholar] [CrossRef]
- Daly, A.C.; Riley, L.; Segura, T.; Burdick, J.A. Hydrogel microparticles for biomedical applications. Nat. Rev. Mater. 2020, 5, 20–43. [Google Scholar] [CrossRef]
- Seong, Y.-J.; Lin, G.; Kim, B.J.; Kim, H.-E.; Kim, S.; Jeong, S.-H. Hyaluronic acid-based hybrid hydrogel microspheres with enhanced structural stability and high injectability. ACS Omega 2019, 4, 13834–13844. [Google Scholar] [CrossRef] [PubMed]
- Fragassi, A.; Greco, A.; Di Francesco, M.; Ceseracciu, L.; Abu Ammar, A.; Dvir, I.; Moore, T.L.; Kasem, H.; Decuzzi, P. Tribological behavior of shape-specific microplate-enriched synovial fluids on a linear two-axis tribometer. Friction 2024, 12, 539–553. [Google Scholar] [CrossRef]
- Di Francesco, M.; Bedingfield, S.K.; Di Francesco, V.; Colazo, J.M.; Yu, F.; Ceseracciu, L.; Bellotti, E.; Di Mascolo, D.; Ferreira, M.; Himmel, L.E. Shape-defined microplates for the sustained intra-articular release of dexamethasone in the management of overload-induced osteoarthritis. ACS Appl. Mater. Interfaces 2021, 13, 31379–31392. [Google Scholar] [CrossRef] [PubMed]
- Butoescu, N.; Seemayer, C.A.; Foti, M.; Jordan, O.; Doelker, E. Dexamethasone-containing PLGA superparamagnetic microparticles as carriers for the local treatment of arthritis. Biomaterials 2009, 30, 1772–1780. [Google Scholar] [CrossRef] [PubMed]
- Maudens, P.; Jordan, O.; Allémann, E. Recent advances in intra-articular drug delivery systems for osteoarthritis therapy. Drug Discov. Today 2018, 23, 1761–1775. [Google Scholar] [CrossRef] [PubMed]
- Han, Y.; Yang, J.; Zhao, W.; Wang, H.; Sun, Y.; Chen, Y.; Luo, J.; Deng, L.; Xu, X.; Cui, W. Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis. Bioact. Mater. 2021, 6, 3596–3607. [Google Scholar] [CrossRef]
- Yang, J.; Han, Y.; Lin, J.; Zhu, Y.; Wang, F.; Deng, L.; Zhang, H.; Xu, X.; Cui, W. Ball-bearing-inspired polyampholyte-modified microspheres as bio-lubricants attenuate osteoarthritis. Small 2020, 16, 2004519. [Google Scholar] [CrossRef]
- Lei, Y.; Wang, Y.; Shen, J.; Cai, Z.; Zhao, C.; Chen, H.; Luo, X.; Hu, N.; Cui, W.; Huang, W. Injectable hydrogel microspheres with self-renewable hydration layers alleviate osteoarthritis. Sci. Adv. 2022, 8, eabl6449. [Google Scholar] [CrossRef]
- Ozkan, H.; Di Francesco, M.; Willcockson, H.; Valdés-Fernández, J.; Di Francesco, V.; Granero-Moltó, F.; Prósper, F.; Decuzzi, P.; Longobardi, L. Sustained inhibition of CC-chemokine receptor-2 via intraarticular deposition of polymeric microplates in post-traumatic osteoarthritis. Drug Deliv. Transl. Res. 2023, 13, 689–701. [Google Scholar] [CrossRef]
- Bedingfield, S.K.; Colazo, J.M.; Di Francesco, M.; Yu, F.; Liu, D.D.; Di Francesco, V.; Himmel, L.E.; Gupta, M.K.; Cho, H.; Hasty, K.A. Top-down fabricated microplates for prolonged, intra-articular matrix metalloproteinase 13 siRNA nanocarrier delivery to reduce post-traumatic osteoarthritis. ACS Nano 2021, 15, 14475–14491. [Google Scholar] [CrossRef]
- Wang, S.; Qiu, Y.; Qu, L.; Wang, Q.; Zhou, Q. Hydrogels for treatment of different degrees of osteoarthritis. Front. Bioeng. Biotechnol. 2022, 10, 858656. [Google Scholar] [CrossRef] [PubMed]
- Lawson, T.B.; Mäkelä, J.T.; Klein, T.; Snyder, B.D.; Grinstaff, M.W. Nanotechnology and Osteoarthritis. Part 2: Opportunities for advanced devices and therapeutics. J. Orthop. Res. 2021, 39, 473–484. [Google Scholar] [CrossRef] [PubMed]
- Liu, G.; Liu, Z.; Li, N.; Wang, X.; Zhou, F.; Liu, W. Hairy polyelectrolyte brushes-grafted thermosensitive microgels as artificial synovial fluid for simultaneous biomimetic lubrication and arthritis treatment. ACS Appl. Mater. Interfaces 2014, 6, 20452–20463. [Google Scholar] [CrossRef] [PubMed]
- Maudens, P.; Meyer, S.; Seemayer, C.A.; Jordan, O.; Allémann, E. Self-assembled thermoresponsive nanostructures of hyaluronic acid conjugates for osteoarthritis therapy. Nanoscale 2018, 10, 1845–1854. [Google Scholar] [CrossRef] [PubMed]
- Zhang, K.; Yang, J.; Sun, Y.; He, M.; Liang, J.; Luo, J.; Cui, W.; Deng, L.; Xu, X.; Wang, B. Thermo-sensitive dual-functional nanospheres with enhanced lubrication and drug delivery for the treatment of osteoarthritis. Chem. A Eur. J. 2020, 26, 10564–10574. [Google Scholar] [CrossRef]
- Yang, L.; Zhao, X.; Zhang, J.; Ma, S.; Jiang, L.; Wei, Q.; Cai, M.; Zhou, F. Synthesis of charged chitosan nanoparticles as functional biolubricant. Colloids Surf. B Biointerfaces 2021, 206, 111973. [Google Scholar] [CrossRef]
- Ren, K.; Ke, X.; Chen, Z.; Zhao, Y.; He, L.; Yu, P.; Xing, J.; Luo, J.; Xie, J.; Li, J. Zwitterionic polymer modified xanthan gum with collagen II-binding capability for lubrication improvement and ROS scavenging. Carbohydr. Polym. 2021, 274, 118672. [Google Scholar] [CrossRef]
- Anilkumar, P.; Lawson, T.B.; Abbina, S.; Mäkelä, J.T.; Sabatelle, R.C.; Takeuchi, L.E.; Snyder, B.D.; Grinstaff, M.W.; Kizhakkedathu, J.N. Mega macromolecules as single molecule lubricants for hard and soft surfaces. Nat. Commun. 2020, 11, 2139. [Google Scholar] [CrossRef]
- Wan, L.; Tan, X.; Sun, T.; Sun, Y.; Luo, J.; Zhang, H. Lubrication and drug release behaviors of mesoporous silica nanoparticles grafted with sulfobetaine-based zwitterionic polymer. Mater. Sci. Eng. C 2020, 112, 110886. [Google Scholar] [CrossRef]
- Liu, G.; Cai, M.; Zhou, F.; Liu, W. Charged polymer brushes-grafted hollow silica nanoparticles as a novel promising material for simultaneous joint lubrication and treatment. J. Phys. Chem. B 2014, 118, 4920–4931. [Google Scholar] [CrossRef]
- Sun, T.; Sun, Y.; Zhang, H. Phospholipid-coated mesoporous silica nanoparticles acting as lubricating drug nanocarriers. Polymers 2018, 10, 513. [Google Scholar] [CrossRef] [PubMed]
- Chen, H.; Sun, T.; Yan, Y.; Ji, X.; Sun, Y.; Zhao, X.; Qi, J.; Cui, W.; Deng, L.; Zhang, H. Cartilage matrix-inspired biomimetic superlubricated nanospheres for treatment of osteoarthritis. Biomaterials 2020, 242, 119931. [Google Scholar] [CrossRef] [PubMed]
- Zhao, W.; Wang, H.; Wang, H.; Han, Y.; Zheng, Z.; Liu, X.; Feng, B.; Zhang, H. Light-responsive dual-functional biodegradable mesoporous silica nanoparticles with drug delivery and lubrication enhancement for the treatment of osteoarthritis. Nanoscale 2021, 13, 6394–6399. [Google Scholar] [CrossRef] [PubMed]
- Yan, Y.; Sun, T.; Zhang, H.; Ji, X.; Sun, Y.; Zhao, X.; Deng, L.; Qi, J.; Cui, W.; Santos, H.A. Euryale ferox seed-inspired superlubricated nanoparticles for treatment of osteoarthritis. Adv. Funct. Mater. 2019, 29, 1807559. [Google Scholar] [CrossRef]
- Lee, Y.; Thompson, D. Stimuli-responsive liposomes for drug delivery. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 2017, 9, e1450. [Google Scholar] [CrossRef] [PubMed]
- Akbarzadeh, A.; Rezaei-Sadabady, R.; Davaran, S.; Joo, S.W.; Zarghami, N.; Hanifehpour, Y.; Samiei, M.; Kouhi, M.; Nejati-Koshki, K. Liposome: Classification, preparation, and applications. Nanoscale Res. Lett. 2013, 8, 1–9. [Google Scholar] [CrossRef]
- Mozafari, M.R. Liposomes: An overview of manufacturing techniques. Cell. Mol. Biol. Lett. 2005, 10, 711. [Google Scholar]
- Dravid, A.A.; Dhanabalan, K.M.; Naskar, S.; Vashistha, A.; Agarwal, S.; Padhan, B.; Dewani, M.; Agarwal, R. Sustained release resolvin D1 liposomes are effective in the treatment of osteoarthritis in obese mice. J. Biomed. Mater. Res. Part A 2023, 111, 765–777. [Google Scholar] [CrossRef]
- Verberne, G.; Schroeder, A.; Halperin, G.; Barenholz, Y.; Etsion, I. Liposomes as potential biolubricant additives for wear reduction in human synovial joints. Wear 2010, 268, 1037–1042. [Google Scholar] [CrossRef]
- Yu, W.-N.; Wu, M.-J.; Chang, P.-C.; Shih, S.-F. Cartilage damage and synovial toxicokinetic study of a sustained release liposomal formulation of dexamethasone sodium phosphate (TLC599) following intra-articular injection in healthy dogs and rabbits. Osteoarthr. Cartil. 2019, 27, S161–S162. [Google Scholar] [CrossRef]
- Wu, T.-J.; Yu, W.-N.; Wu, M.-J.; Chang, P.-C.; Shih, S.-F. Thu0465 pharmacokinetics and toxicokinetics studies of a sustained release liposomal formulation of dexamethasone sodium phosphate (tlc599) following intra-articular injection in dogs. Ann. Rheum. Dis. 2019, 78, 523. [Google Scholar]
- Hunter, D.J.; Chang, C.-C.; Wei, J.C.-C.; Lin, H.-Y.; Brown, C.; Tai, T.-T.; Wu, C.-F.; Chuang, W.C.-M.; Shih, S.-F. TLC599 in patients with osteoarthritis of the knee: A phase IIa, randomized, placebo-controlled, dose-finding study. Arthritis Res. Ther. 2022, 24, 52. [Google Scholar] [CrossRef] [PubMed]
- Elron-Gross, I.; Glucksam, Y.; Biton, I.E.; Margalit, R. A novel Diclofenac-carrier for local treatment of osteoarthritis applying live-animal MRI. J. Control. Release 2009, 135, 65–70. [Google Scholar] [CrossRef] [PubMed]
- Corciulo, C.; Castro, C.M.; Coughlin, T.; Jacob, S.; Li, Z.; Fenyö, D.; Rifkin, D.B.; Kennedy, O.D.; Cronstein, B.N. Intraarticular injection of liposomal adenosine reduces cartilage damage in established murine and rat models of osteoarthritis. Sci. Rep. 2020, 10, 13477. [Google Scholar] [CrossRef]
- Kim, H.-R.; Cho, H.B.; Lee, S.; Park, J.-I.; Kim, H.J.; Park, K.-H. Fusogenic liposomes encapsulating mitochondria as a promising delivery system for osteoarthritis therapy. Biomaterials 2023, 302, 122350. [Google Scholar] [CrossRef]
- Marian, M.; Shah, R.; Gashi, B.; Zhang, S.; Bhavnani, K.; Wartzack, S.; Rosenkranz, A. Exploring the lubrication mechanisms of synovial fluids for joint longevity–a perspective. Colloids Surf. B Biointerfaces 2021, 206, 111926. [Google Scholar] [CrossRef]
- Wang, M.; Liu, C.; Thormann, E.; Dedinaite, A. Hyaluronan and phospholipid association in biolubrication. Biomacromolecules 2013, 14, 4198–4206. [Google Scholar] [CrossRef]
- Hills, B.; Monds, M. Deficiency of lubricating surfactant lining the articular surfaces of replaced hips and knees. Br. J. Rheumatol. 1998, 37, 143–147. [Google Scholar] [CrossRef]
- Kawano, T.; Miura, H.; Mawatari, T.; Moro-Oka, T.; Nakanishi, Y.; Higaki, H.; Iwamoto, Y. Mechanical effects of the intraarticular administration of high molecular weight hyaluronic acid plus phospholipid on synovial joint lubrication and prevention of articular cartilage degeneration in experimental osteoarthritis. Arthritis Rheum. Off. J. Am. Coll. Rheumatol. 2003, 48, 1923–1929. [Google Scholar] [CrossRef]
- Sivan, S.; Schroeder, A.; Verberne, G.; Merkher, Y.; Diminsky, D.; Priev, A.; Maroudas, A.; Halperin, G.; Nitzan, D.; Etsion, I. Liposomes act as effective biolubricants for friction reduction in human synovial joints. Langmuir 2010, 26, 1107–1116. [Google Scholar] [CrossRef]
- Goldberg, R.; Schroeder, A.; Silbert, G.; Turjeman, K.; Barenholz, Y.; Klein, J. Boundary lubricants with exceptionally low friction coefficients based on 2D close-packed phosphatidylcholine liposomes. Adv. Mater. 2011, 23, 3517. [Google Scholar] [CrossRef] [PubMed]
- Zhong, Y.; Zhou, Y.; Ding, R.; Zou, L.; Zhang, H.; Wei, X.; He, D. Intra-articular treatment of temporomandibular joint osteoarthritis by injecting actively-loaded meloxicam liposomes with dual-functions of anti-inflammation and lubrication. Mater. Today Bio 2023, 19, 100573. [Google Scholar] [CrossRef] [PubMed]
Lubricant | Structure | Properties | Concentration (mg/mL) | |
---|---|---|---|---|
Healthy | Osteoarthritis | |||
Hyaluronic Acid | Repeating disaccharide units of D-glucuronic acid and D-N-acetylglucosamine attached by β (1–4) and β (1–3) glycosidic bonds | HA creates the backbone for PGs of the ECM, protects the cartilage, and blocks the loss of PGs from the cartilage matrix into the synovial space maintaining the physical form of the ECM. | 1.6–3.7 | 1.1–1.9 |
Lubricin | It is composed by a central mucin-like domain with negatively charged and hydrophilic properties, between two non-glycosylated with positively charged and hydrophobic properties | In the outer superficial zone and at the cartilage surface it interacts with and immobilizes HA | 0.305–0.404 | 0.108–0.183 |
Phospholipids | Amphiphilic molecules with two hydrophobic diacyl tails and a hydrophilic phosphocholine head group | These exposed groups slide past similar groups from the opposing surface with low friction up to high pressures (100 atm or more) via the hydration lubrication mechanism | 0.13–0.15 | 0.23–0.98 |
Physiological effects |
Maintenance of SF viscoelasticity Maintenance of cartilage bio-lubrication Backbone of cartilage ECM |
Pharmacological effects |
Scavenges ROS/RNS and exerts antioxidative effect Exerts anti-inflammatory effect Reduces production of MMPs (MMP-1, MMP-3, and MMP-13) Reduces production and activity of IL-1β, and other pro-inflammatory mediators Inhibits synthesis of PGE2 and bradykinin Regulates fibroblast proliferation Inhibits migration and aggregation of leukocyte and macrophages Enhances synthesis of chondrocytes, HA, and PG Improves viscoelasticity and enhances lubricating potential Improves joint function, mobility, and reduces stiffness |
Product | Molecular Weight kDa | Dose (mg) | Frequency | Cross-Linking |
---|---|---|---|---|
Hyalgan | 500–730 | 20 (5 doses) | Weekly | No |
Supartz FX | 620–1170 | 25 (5 doses) | Weekly | No |
Monovisc | 1000–2900 | 88 (1 dose) | Once | Yes |
Orthovisc | 1000–2900 | 30 (3-4 doses) | Weekly | No |
Euflexaa | 2400–3600 | 20 (3 doses) | Weekly | No |
Synivisc | 6000 | 16 (3 doses) | Weekly | Yes |
Durolane | 100,000 | 60 (1 dose) | Once | No |
Gel-one | ∞ | 30 (1 dose) | Once | Yes |
Synivisc-One | ∞ | 48 (1 dose) | Once | Yes |
Name and Nanoparticle Structure | Material | Size | Outcomes | Ref. |
---|---|---|---|---|
MSNs@pSBM-3 | MSNs grafted with pSBMA-3 | ~100 nm | Improved lubrication properties (μ = 0.045) and reduction of 80% in the coefficient of friction when compared with MSNs (μ = 0.221). | [92] |
PSPMA-g-HSNPs-0.5% | Core/shell charged polymer brush-grafted hollow MSNs | ~739 nm | Controlled drug loading and release; good lubricant effect (μ = 0.173) and reduced coefficient of friction. | [93] |
MSNs@lip | Phospholipid-coated MSNs | 150–350 nm | Reduced coefficient of friction (μ = 0.05) in comparison with MSNs (μ = 0.2). | [94] |
MSNs-NH2@PMPC | PMPC-grafted MSNs | ~260 nm | Enhanced lubrication (μ = 0.015) activity. | [95] |
bMSNs-AZO/CD-PMPC | MSNs modified surface with AZO and CD-PMPC | ~150 nm | Improved lubrication (μ < 0.04) and enhanced drug release efficiency upon visible light irradiation. | [96] |
MSNs-NH2@PSPMK | PSPMK-grafted MSNs | ~114 nm | Great drug loading capability and controlled release, enhanced lubrication in the joint (µ ~ 0.065), and chondrocytes protection. | [97] |
Name/Developer and Liposome Structure | Material | Size | Outcomes | Ref. |
---|---|---|---|---|
TLC599 | DOPC DOPG Cholesterol DSP Dexametason | ~150 nm | Long-lasting profile remaining up to 120 days in synovial joint after a single AI in preclinical study in dogs. | [103] |
Collagomer | DPPE Collagen I Diclofenac | ~10 µm | Significant reduction of inflammation in a rat model of OA. | [104] |
Corciulo, et al. | PC Cholesterol | ND | Significant decrease of OA cartilage damage in a murine model of obesity induced OA. | [105] |
Kim et al. | PE DOTAP Liss Rhod PE Mitochondria | 600–700 nm | Significant decrease of inflammatory cytokines; significant increase in ECM components expression. | [106] |
Zhong et al. | HSPC DSPE-PEG2000 Cholesterol Meloxicam | 110–125 nm * | Reduced ECM degeneration and reduced synthesis of inflammatory factors in mandibular ramus of rats. | [115] |
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Fragassi, A.; Greco, A.; Palomba, R. Lubricant Strategies in Osteoarthritis Treatment: Transitioning from Natural Lubricants to Drug Delivery Particles with Lubricant Properties. J. Xenobiot. 2024, 14, 1268-1292. https://doi.org/10.3390/jox14030072
Fragassi A, Greco A, Palomba R. Lubricant Strategies in Osteoarthritis Treatment: Transitioning from Natural Lubricants to Drug Delivery Particles with Lubricant Properties. Journal of Xenobiotics. 2024; 14(3):1268-1292. https://doi.org/10.3390/jox14030072
Chicago/Turabian StyleFragassi, Agnese, Antonietta Greco, and Roberto Palomba. 2024. "Lubricant Strategies in Osteoarthritis Treatment: Transitioning from Natural Lubricants to Drug Delivery Particles with Lubricant Properties" Journal of Xenobiotics 14, no. 3: 1268-1292. https://doi.org/10.3390/jox14030072