ASB6

Ankyrin repeat and SOCS box protein 6 is a protein that in humans is encoded by the ASB6 gene.

ASB6
Identifiers
Aliases	ASB6, ankyrin repeat and SOCS box containing 6
External IDs	OMIM: 615051; MGI: 1919573; HomoloGene: 9895; GeneCards: ASB6; OMA:ASB6 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q34.11 Start 129,634,604 bp End 129,642,169 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 B Start 30,713,109 bp End 30,720,345 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte right frontal lobe gastric mucosa right hemisphere of cerebellum prefrontal cortex left adrenal cortex middle temporal gyrus right adrenal cortex anterior cingulate cortex skin of leg Top expressed in fetal liver hematopoietic progenitor cell granulocyte yolk sac lip epiblast right kidney submandibular gland neural layer of retina embryo ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm cytosol Biological process intracellular signal transduction protein ubiquitination post-translational protein modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 140459 72323 Ensembl ENSG00000148331 ENSMUSG00000039483 UniProt Q9NWX5 Q91ZU1 RefSeq (mRNA) NM_177999 NM_001202403 NM_017873 NM_133346 RefSeq (protein) NP_001189332 NP_060343 NP_821066 NP_579924 Location (UCSC) Chr 9: 129.63 – 129.64 Mb Chr 2: 30.71 – 30.72 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases.

External links

• Human ASB6 genome location and ASB6 gene details page in the UCSC Genome Browser.

Further reading

• Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wilcox A, Katsanakis KD, Bheda F, Pillay TS (2004). "Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex". J. Biol. Chem. 279 (37): 38881–8. doi:10.1074/jbc.M406101200. PMID 15231829.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.