CFU-Meg is a colony forming unit. Haematopoiesis in the bone marrow starts off from a haematopoietic stem cell (HSC) and this can differentiate into the myeloid and lymphoid cell lineages. In order to eventually produce a megakaryocyte, the haematopoietic stem cell must generate myeloid cells, so it becomes a common myeloid progenitor, CFU-GEMM. This in turn develops into CFU-Meg, which is the colony forming unit that leads to the production of megakaryocytes.[1][2][3]
| CFU-Meg | |
|---|---|
| Details | |
| Gives rise to | Megakaryocytes and those to platelets |
| Location | Bone marrow |
| Function | Colony forming unit |
| Identifiers | |
| TH | H2.00.04.3.02013 |
| Anatomical terms of microanatomy | |
Some sources prefer the term "CFU-Mega".[4]
See also
editReferences
edit- ^ Kimura H, Ohkoshi T, Matsuda S, Uchida T, Kariyone S (1988). "Megakaryocytopoiesis in polycythemia vera: characterization by megakaryocytic progenitors (CFU-Meg) in vitro and quantitation of marrow megakaryocytes". Acta Haematol. 79 (1): 1–6. doi:10.1159/000205681. PMID 3124455.
- ^ Kimura H, Ishibashi T, Sato T, Matsuda S, Uchida T, Kariyone S (January 1987). "Megakaryocytic colony formation (CFU-Meg) in essential thrombocythemia: quantitative and qualitative abnormalities of bone marrow CFU-Meg". Am. J. Hematol. 24 (1): 23–30. doi:10.1002/ajh.2830240104. PMID 3799592. S2CID 20893511.
- ^ Gallicchio VS, Hughes NK, Hulette BC, Noblitt L (December 1991). "Effect of interleukin-1, GM-CSF, erythropoietin, and lithium on the toxicity associated with 3'-azido-3'-deoxythymidine (AZT) in vitro on hematopoietic progenitors (CFU-GM, CFU-MEG, and BFU-E) using murine retrovirus-infected hematopoietic cells". J. Leukoc. Biol. 50 (6): 580–6. doi:10.1002/jlb.50.6.580. PMID 1940611. S2CID 9700067.[permanent dead link]
- ^ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease. St. Louis, Mo: Elsevier Saunders. p. 621. ISBN 0-7216-0187-1.
External links
edit- Megakaryocyte+Progenitor+Cells at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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