CGS-12066A

CGS-12066A
Identifiers
	IUPAC name 4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline;
CAS Number	109028-10-6 ;
PubChem CID	2689;
IUPHAR/BPS	109;
ChemSpider	2588 ;
UNII	VJ9I4R0C0C;
CompTox Dashboard (EPA)	DTXSID3043730 ;
Chemical and physical data
Formula	C17H17F3N4
Molar mass	334.346 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C3CN(C)CCN3c2nc1cc(C(F)(F)F)ccc1n4cccc24;
	InChI InChI=1S/C17H17F3N4/c1-22-7-9-23(10-8-22)16-15-3-2-6-24(15)14-5-4-12(17(18,19)20)11-13(14)21-16/h2-6,11H,7-10H2,1H3 ; Key:LXFHSCDLMBZYKY-UHFFFAOYSA-N ;
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CGS-12066A is a drug which acts as a potent and selective agonist for the 5-HT_1B receptor with lower affinity for the three 5-HT₂ receptor subtypes.^[1]^[2] It is used for studying the role of the 5-HT_1B receptor in various processes including perception of pain and the sleep-wake cycle.^[3]^[4]

References

^ Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M (August 2004). "Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors". Naunyn-Schmiedeberg's Archives of Pharmacology. 370 (2): 114–23. doi:10.1007/s00210-004-0951-4. PMID 15322733. S2CID 8938111.
^ Jeong HS, Jang MJ, Park JS (March 2005). "Effects of CGS-12066A on medial vestibular nuclear neurons". Brain Research. 1038 (1): 118–21. doi:10.1016/j.brainres.2005.01.025. PMID 15748881. S2CID 22734919.
^ Monti JM, Jantos H (2008). "The roles of dopamine and serotonin, and of their receptors, in regulating sleep and waking". Serotonin–Dopamine Interaction: Experimental Evidence and Therapeutic Relevance. Progress in Brain Research. Vol. 172. pp. 625–46. doi:10.1016/S0079-6123(08)00929-1. ISBN 9780444532350. PMID 18772053.
^ Granados-Soto V, Argüelles CF, Rocha-González HI, Godínez-Chaparro B, Flores-Murrieta FJ, Villalón CM (January 2010). "The role of peripheral 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in rats". Neuroscience. 165 (2): 561–8. doi:10.1016/j.neuroscience.2009.10.020. PMID 19837141. S2CID 195684404.

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[1] Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M (August 2004). "Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors". Naunyn-Schmiedeberg's Archives of Pharmacology. 370 (2): 114–23. doi:10.1007/s00210-004-0951-4. PMID 15322733. S2CID 8938111.

[2] Jeong HS, Jang MJ, Park JS (March 2005). "Effects of CGS-12066A on medial vestibular nuclear neurons". Brain Research. 1038 (1): 118–21. doi:10.1016/j.brainres.2005.01.025. PMID 15748881. S2CID 22734919.

[3] Monti JM, Jantos H (2008). "The roles of dopamine and serotonin, and of their receptors, in regulating sleep and waking". Serotonin–Dopamine Interaction: Experimental Evidence and Therapeutic Relevance. Progress in Brain Research. Vol. 172. pp. 625–46. doi:10.1016/S0079-6123(08)00929-1. ISBN 9780444532350. PMID 18772053.

[4] Granados-Soto V, Argüelles CF, Rocha-González HI, Godínez-Chaparro B, Flores-Murrieta FJ, Villalón CM (January 2010). "The role of peripheral 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in rats". Neuroscience. 165 (2): 561–8. doi:10.1016/j.neuroscience.2009.10.020. PMID 19837141. S2CID 195684404.

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Identifiers

IUPAC name 4-(4-methylpiperazin-1-yl)-7-(trifluoromethyl)pyrrolo[1,2-a]quinoxaline
CAS Number	109028-10-6^Y
PubChem CID	2689
IUPHAR/BPS	109
ChemSpider	2588^N
UNII	VJ9I4R0C0C
CompTox Dashboard (EPA)	DTXSID3043730
Chemical and physical data
Formula	C₁₇H₁₇F₃N₄
Molar mass	334.346 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C3CN(C)CCN3c2nc1cc(C(F)(F)F)ccc1n4cccc24
InChI InChI=1S/C17H17F3N4/c1-22-7-9-23(10-8-22)16-15-3-2-6-24(15)14-5-4-12(17(18,19)20)11-13(14)21-16/h2-6,11H,7-10H2,1H3^N Key:LXFHSCDLMBZYKY-UHFFFAOYSA-N^N
^NY (what is this?) (verify)