Hypodiploid acute lymphoblastic leukemia is the chromosome mutation of leukemic cells with 45 chromosomes or less. It has been determined that the prognosis of hypodiploid is much worse than standard acute lymphoblastic leukemia.[1] The lower the chromosome count, the lower the survival rate. In a study documented by the American Society of Hematology 17 of 27 patients relapsed, which indicates poor treatment responsiveness of hypodiploid ALL.[2] Hypodiploidy is an unfavorable karyotypic feature in childhood ALL.[3]
References
edit- ^ Nyla A. Heerema; James B. Nachman; Harland N. Sather; Martha G. Sensel; Mei K. Lee; Raymond Hutchinson; Beverly J. Lange; Peter G. Steinherz; Bruce Bostrom; Paul S. Gaynon; Fatih Uckun (December 15, 1999). "Hypodiploidy with Less Than 45 Chromosomes Confers Adverse Risk in Childhood Acute Lymphoblastic Leukemia: A Report from the Children's Cancer Group". Blood. 94 (12): 4036–45. PMID 10590047.
- ^ CH Pui; AJ Carroll; SC Raimondi; VJ Land; WM Crist; JJ Shuster; DL Williams; DJ Pullen; MJ Borowitz; FG Behm (March 1, 1990). "Clinical Presentation, Karyotypic Characterization, and Treatment Outcome of Childhood Acute Lymphoblastic Leukemia with a Near-Haploid or Hypodiploid Less Than 45 Line". Blood. 75 (5): 1170–77. doi:10.1182/blood.V75.5.1170.1170. PMID 2306521.
- ^ CH Pui; DL Williams; SC Raimondi; GK Rivera; AT Look; RK Dodge; SL George; FG Behm; WM Crist; SB Murphy (July 1, 1987). "Hypodiploidy Is Associated with a Poor Prognosis in Childhood Acute Lymphoblastic Leukemia". Blood. 70 (1): 247–53. doi:10.1182/blood.V70.1.247.247. PMID 3474042.
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