ID3 (gene)

DNA-binding protein inhibitor ID-3 is a protein that in humans is encoded by the ID3 gene.

ID3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LFH
Identifiers
Aliases	ID3, HEIR-1, bHLHb25, inhibitor of DNA binding 3, HLH protein
External IDs	OMIM: 600277; MGI: 96398; HomoloGene: 1633; GeneCards: ID3; OMA:ID3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.12 Start 23,557,926 bp End 23,559,501 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 D3|4 68.34 cM Start 135,870,808 bp End 135,873,066 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland Descending thoracic aorta left lobe of thyroid gland ascending aorta right coronary artery popliteal artery tibial arteries left coronary artery left uterine tube right auricle Top expressed in endothelial cell of lymphatic vessel otic placode endocardial cushion body of femur medullary collecting duct choroid plexus of fourth ventricle hand seminal vesicula optic nerve molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein dimerization activity leptomycin B binding transcription corepressor activity protein domain specific binding DNA-binding transcription factor activity transcription factor binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleus Biological process negative regulation of myoblast differentiation regulation of transcription, DNA-templated epithelial cell differentiation rhythmic process regulation of DNA replication muscle organ development notochord development negative regulation of transcription by RNA polymerase II negative regulation of DNA-binding transcription factor activity negative regulation of osteoblast differentiation transcription, DNA-templated negative regulation of gene expression regulation of cell cycle odontogenesis multicellular organism development heart development central nervous system development response to wounding circadian rhythm neuron differentiation positive regulation of apoptotic process metanephros development negative regulation of transcription, DNA-templated cellular response to leptomycin B negative regulation of DNA binding negative regulation of neuron differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3399 15903 Ensembl ENSG00000283060 ENSG00000117318 ENSMUSG00000007872 UniProt Q02535 P41133 RefSeq (mRNA) NM_002167 NM_008321 RefSeq (protein) NP_002158 NP_032347 Location (UCSC) Chr 1: 23.56 – 23.56 Mb Chr 4: 135.87 – 135.87 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

Members of the ID family of helix-loop-helix (HLH) proteins lack a basic DNA-binding domain and inhibit transcription through formation of nonfunctional dimers that are incapable of binding to DNA.[supplied by OMIM]

Interactions

ID3 (gene) has been shown to interact with TCF3.

Repressors of ID3

BTG2 binds to the promoter of Id3 and represses its activity. By this mechanism, the upregulation of Id3 in the hippocampus caused by BTG2 ablation prevents terminal differentiation of hippocampal neurons.

See also

• Inhibitor of DNA-binding protein

Further reading

• White PS, Maris JM, Beltinger C, Sulman E, Marshall HN, Fujimori M, Kaufman BA, Biegel JA, Allen C, Hilliard C, Valentine MB, Look AT, Enomoto H, Sakiyama S, Brodeur GM (1995). "A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3". Proc. Natl. Acad. Sci. U.S.A. 92 (12): 5520–4. Bibcode:1995PNAS...92.5520W. doi:10.1073/pnas.92.12.5520. PMC 41727. PMID 7777541.
• Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, Yokoyama-Kobayashi M, Aoki T (1994). "Construction of a human full-length cDNA bank". Gene. 150 (2): 243–50. doi:10.1016/0378-1119(94)90433-2. PMID 7821789.
• Deed RW, Hirose T, Mitchell EL, Santibanez-Koref MF, Norton JD (1994). "Structural organisation and chromosomal mapping of the human Id-3 gene". Gene. 151 (1–2): 309–14. doi:10.1016/0378-1119(94)90676-9. PMID 7828896.
• Deed RW, Bianchi SM, Atherton GT, Johnston D, Santibanez-Koref M, Murphy JJ, Norton JD (1993). "An immediate early human gene encodes an Id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types". Oncogene. 8 (3): 599–607. PMID 8437843.
• Ishiguro A, Spirin K, Shiohara M, Tobler A, Norton JD, Rigolet M, Shimbo T, Koeffler HP (1995). "Expression of Id2 and Id3 mRNA in human lymphocytes". Leuk. Res. 19 (12): 989–96. doi:10.1016/0145-2126(95)00084-4. PMID 8632670.
• Wibley J, Deed R, Jasiok M, Douglas K, Norton J (1996). "A homology model of the Id-3 helix-loop-helix domain as a basis for structure-function predictions". Biochim. Biophys. Acta. 1294 (2): 138–46. doi:10.1016/0167-4838(96)00008-8. PMID 8645731.
• Loveys DA, Streiff MB, Kato GJ (1996). "E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein". Nucleic Acids Res. 24 (14): 2813–20. doi:10.1093/nar/24.14.2813. PMC 145994. PMID 8759016.
• Deed RW, Armitage S, Norton JD (1996). "Nuclear localization and regulation of Id protein through an E protein-mediated chaperone mechanism". J. Biol. Chem. 271 (39): 23603–6. doi:10.1074/jbc.271.39.23603. PMID 8798572.
• Deed RW, Jasiok M, Norton JD (1996). "Attenuated function of a variant form of the helix-loop-helix protein, Id-3, generated by an alternative splicing mechanism". FEBS Lett. 393 (1): 113–6. Bibcode:1996FEBSL.393..113D. doi:10.1016/0014-5793(96)00868-X. PMID 8804437. S2CID 27733563.
• Chen B, Lim RW (1997). "Physical and functional interactions between the transcriptional inhibitors Id3 and ITF-2b. Evidence toward a novel mechanism regulating muscle-specific gene expression". J. Biol. Chem. 272 (4): 2459–63. doi:10.1074/jbc.272.4.2459. PMID 8999959.
• Langlands K, Yin X, Anand G, Prochownik EV (1997). "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". J. Biol. Chem. 272 (32): 19785–93. doi:10.1074/jbc.272.32.19785. PMID 9242638.
• Deed RW, Hara E, Atherton GT, Peters G, Norton JD (1997). "Regulation of Id3 cell cycle function by Cdk-2-dependent phosphorylation". Mol. Cell. Biol. 17 (12): 6815–21. doi:10.1128/MCB.17.12.6815. PMC 232537. PMID 9372912.
• Deed RW, Jasiok M, Norton JD (1998). "Lymphoid-specific expression of the Id3 gene in hematopoietic cells. Selective antagonism of E2A basic helix-loop-helix protein associated with Id3-induced differentiation of erythroleukemia cells". J. Biol. Chem. 273 (14): 8278–86. doi:10.1074/jbc.273.14.8278. PMID 9525934.
• Asp J, Thornemo M, Inerot S, Lindahl A (1998). "The helix-loop-helix transcription factors Id1 and Id3 have a functional role in control of cell division in human normal and neoplastic chondrocytes". FEBS Lett. 438 (1–2): 85–90. Bibcode:1998FEBSL.438...85A. doi:10.1016/S0014-5793(98)01268-X. PMID 9821964. S2CID 22138517.
• Yates PR, Atherton GT, Deed RW, Norton JD, Sharrocks AD (1999). "Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors". EMBO J. 18 (4): 968–76. doi:10.1093/emboj/18.4.968. PMC 1171189. PMID 10022839.
• Moldes M, Boizard M, Liepvre XL, Fève B, Dugail I, Pairault J (1999). "Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adipocytes". Biochem. J. 344. 344 Pt 3 (3): 873–80. doi:10.1042/0264-6021:3440873. PMC 1220711. PMID 10585876.
• Bounpheng MA, Dimas JJ, Dodds SG, Christy BA (1999). "Degradation of Id proteins by the ubiquitin-proteasome pathway". FASEB J. 13 (15): 2257–64. doi:10.1096/fasebj.13.15.2257. PMID 10593873. S2CID 12697752.
• Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
• Jögi A, Persson P, Grynfeld A, Påhlman S, Axelson H (2002). "Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation". J. Biol. Chem. 277 (11): 9118–26. doi:10.1074/jbc.M107713200. PMID 11756408.

External links

• ID3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.