MAGEA2

Melanoma-associated antigen 2 is a protein that in humans is encoded by the MAGEA2 gene.

MAGEA2
Identifiers
Aliases	MAGEA2, CT1.2, MAGE2, MAGEA2A, MAGE family member A2
External IDs	OMIM: 300173; HomoloGene: 18781; GeneCards: MAGEA2; OMA:MAGEA2 - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq28 Start 152,749,863 bp End 152,753,884 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad right testis left testis sural nerve placenta muscle of thigh prefrontal cortex olfactory zone of nasal mucosa endometrium n/a More reference expression data BioGPS n/a
Gene ontology Molecular function histone deacetylase binding protein binding ubiquitin protein ligase binding Cellular component PML body nucleus Biological process signal transduction by p53 class mediator cellular senescence negative regulation of protein sumoylation regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II positive regulation of ubiquitin-protein transferase activity transcription, DNA-templated negative regulation of protein acetylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4101 n/a Ensembl ENSG00000268606 n/a UniProt P43356 n/a RefSeq (mRNA) NM_001282501 NM_001282502 NM_001282504 NM_001282505 NM_005361 NM_175742 NM_175743 NM_001386130 n/a RefSeq (protein) NP_001269430 NP_001269431 NP_001269433 NP_001269434 NP_005352 NP_786884 NP_786885 n/a Location (UCSC) Chr X: 152.75 – 152.75 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.

Further reading

• Brasseur F, Rimoldi D, Liénard D, et al. (1995). "Expression of MAGE genes in primary and metastatic cutaneous melanoma". Int. J. Cancer. 63 (3): 375–80. doi:10.1002/ijc.2910630313. PMID 7591235. S2CID 38676798.
• De Plaen E, Arden K, Traversari C, et al. (1994). "Structure, chromosomal localization, and expression of 12 genes of the MAGE family". Immunogenetics. 40 (5): 360–9. doi:10.1007/BF01246677. PMID 7927540. S2CID 11331427.
• Gaugler B, Van den Eynde B, van der Bruggen P, et al. (1994). "Human gene MAGE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T lymphocytes". J. Exp. Med. 179 (3): 921–30. doi:10.1084/jem.179.3.921. PMC 2191409. PMID 8113684.
• De Smet C, Lurquin C, van der Bruggen P, et al. (1994). "Sequence and expression pattern of the human MAGE2 gene". Immunogenetics. 39 (2): 121–9. doi:10.1007/bf00188615. PMID 8276455. S2CID 13579671.
• Zakut R, Topalian SL, Kawakami Y, et al. (1993). "Differential expression of MAGE-1, -2, and -3 messenger RNA in transformed and normal human cell lines". Cancer Res. 53 (1): 5–8. PMID 8416750.
• Mallon AM, Platzer M, Bate R, et al. (2000). "Comparative genome sequence analysis of the Bpa/Str region in mouse and Man". Genome Res. 10 (6): 758–75. doi:10.1101/gr.10.6.758. PMC 310879. PMID 10854409.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nagao T, Higashitsuji H, Nonoguchi K, et al. (2003). "MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity". J. Biol. Chem. 278 (12): 10668–74. doi:10.1074/jbc.M206104200. hdl:2433/148472. PMID 12525503.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Monte M, Simonatto M, Peche LY, et al. (2006). "MAGE-A tumor antigens target p53 transactivation function through histone deacetylase recruitment and confer resistance to chemotherapeutic agents". Proc. Natl. Acad. Sci. U.S.A. 103 (30): 11160–5. Bibcode:2006PNAS..10311160M. doi:10.1073/pnas.0510834103. PMC 1544058. PMID 16847267.
• Wischnewski F, Friese O, Pantel K, Schwarzenbach H (2007). "Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters". Mol. Cancer Res. 5 (7): 749–59. doi:10.1158/1541-7786.MCR-06-0364. PMID 17634428.