Rothermel is a surname. Notable people with the surname include:
- Addison Rothermel (1892–1958), American film actor and director
- Bobby Rothermel (1870–1927), American infielder in Major League Baseball in 1899
- John Hoover Rothermel (1856–1922), Democratic member of the U.S. House of Representatives from Pennsylvania
- P. Frederick Rothermel (1850–1929), Pennsylvania lawyer and politician
- Paula Rothermel (born 1963), leading UK academic in the field of home education
- Peter F. Rothermel (1817–1895), American painter
- Rolf Hans Rothermel, British architect