SNX1

Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin. SNX1 is a component of the retromer complex.

SNX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2I4K, 4FZS
Identifiers
Aliases	SNX1, HsT17379, VPS5, sorting nexin 1
External IDs	OMIM: 601272; MGI: 1928395; HomoloGene: 99716; GeneCards: SNX1; OMA:SNX1 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q22.31 Start 64,094,123 bp End 64,146,090 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 C Start 65,995,415 bp End 66,033,869 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland left lobe of thyroid gland right adrenal gland right adrenal cortex left adrenal gland monocyte upper lobe of left lung ectocervix C1 segment left adrenal cortex Top expressed in spermatocyte gastrula spermatid decidua blastocyst saccule morula yolk sac lens ventricular zone More reference expression data BioGPS n/a
Gene ontology Molecular function protein homodimerization activity insulin receptor binding leptin receptor binding epidermal growth factor receptor binding protein binding phosphatidylinositol binding identical protein binding protein heterodimerization activity transferrin receptor binding lipid binding cadherin binding Cellular component cytoplasm cytosol Golgi apparatus cell projection early endosome membrane membrane retromer, tubulation complex intracellular membrane-bounded organelle retromer complex early endosome endosome membrane lamellipodium extrinsic component of membrane vesicle lysosome endosome protein-containing complex Biological process positive regulation of protein catabolic process vesicle organization early endosome to Golgi transport receptor internalization endosomal transport retrograde transport, endosome to Golgi protein transport intracellular protein transport lamellipodium morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6642 56440 Ensembl ENSG00000028528 ENSMUSG00000032382 UniProt Q13596 Q9WV80 RefSeq (mRNA) NM_001242933 NM_003099 NM_148955 NM_152826 NM_019727 RefSeq (protein) NP_001229862 NP_003090 NP_683758 NP_062701 Location (UCSC) Chr 15: 64.09 – 64.15 Mb Chr 9: 66 – 66.03 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with other family members.

Further reading

• Parks WT, Frank DB, Huff C, et al. (2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases". J. Biol. Chem. 276 (22): 19332–9. doi:10.1074/jbc.M100606200. PMID 11279102.
• Cozier GE, Carlton J, McGregor AH, et al. (2002). "The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation". J. Biol. Chem. 277 (50): 48730–6. doi:10.1074/jbc.M206986200. PMID 12198132.
• Shank BB, Wiley HS, Kurten RC (2001). "Structural and functional characterization of the human gene for sorting nexin 1 (SNX1)". DNA Cell Biol. 20 (5): 287–96. doi:10.1089/104454901750232481. PMID 11410165.
• Liu H, Liu ZQ, Chen CX, et al. (2006). "Inhibitory regulation of EGF receptor degradation by sorting nexin 5". Biochem. Biophys. Res. Commun. 342 (2): 537–46. doi:10.1016/j.bbrc.2006.01.179. PMID 16487940.
• Bryant DM, Kerr MC, Hammond LA, et al. (2007). "EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin". J. Cell Sci. 120 (Pt 10): 1818–28. doi:10.1242/jcs.000653. PMID 17502486. S2CID 24175340.
• Simpson F, Martin S, Evans TM, et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1". Traffic. 6 (6): 442–58. doi:10.1111/j.1600-0854.2005.00289.x. PMID 15882442. S2CID 25389776.
• Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res. 288 (1): 35–50. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.
• Zhong Q, Watson MJ, Lazar CS, et al. (2005). "Determinants of the endosomal localization of sorting nexin 1". Mol. Biol. Cell. 16 (4): 2049–57. doi:10.1091/mbc.E04-06-0504. PMC 1073682. PMID 15673616.
• Mari M, Bujny MV, Zeuschner D, et al. (2008). "SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors". Traffic. 9 (3): 380–93. doi:10.1111/j.1600-0854.2007.00686.x. PMID 18088323. S2CID 31922423.
• Nguyen LN, Holdren MS, Nguyen AP, et al. (2006). "Sorting nexin 1 down-regulation promotes colon tumorigenesis". Clin. Cancer Res. 12 (23): 6952–9. doi:10.1158/1078-0432.CCR-06-0317. hdl:11336/31768. PMID 17145813.
• Pons V, Hullin-Matsuda F, Nauze M, et al. (2003). "Enterophilin-1, a new partner of sorting nexin 1, decreases cell surface epidermal growth factor receptor". J. Biol. Chem. 278 (23): 21155–61. doi:10.1074/jbc.M211008200. PMID 12657642.
• Rojas R, Kametaka S, Haft CR, Bonifacino JS (2007). "Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors". Mol. Cell. Biol. 27 (3): 1112–24. doi:10.1128/MCB.00156-06. PMC 1800681. PMID 17101778.
• Gullapalli A, Wolfe BL, Griffin CT, et al. (2006). "An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins". Mol. Biol. Cell. 17 (3): 1228–38. doi:10.1091/mbc.E05-09-0899. PMC 1382312. PMID 16407403.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhong Q, Lazar CS, Tronchère H, et al. (2002). "Endosomal localization and function of sorting nexin 1". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6767–72. Bibcode:2002PNAS...99.6767Z. doi:10.1073/pnas.092142699. PMC 124477. PMID 11997453.
• Wang Y, Zhou Y, Szabo K, et al. (2002). "Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1". Mol. Biol. Cell. 13 (6): 1965–76. doi:10.1091/mbc.E01-11-0131. PMC 117618. PMID 12058063.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Carlton J, Bujny M, Peter BJ, et al. (2004). "Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides". Curr. Biol. 14 (20): 1791–800. doi:10.1016/j.cub.2004.09.077. hdl:1874/12362. PMID 15498486. S2CID 10366991.
• Kurten RC, Eddington AD, Chowdhury P, et al. (2001). "Self-assembly and binding of a sorting nexin to sorting endosomes". J. Cell Sci. 114 (Pt 9): 1743–56. doi:10.1242/jcs.114.9.1743. PMID 11309204.

External links

• sorting+nexins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.