SOCS4

SOCS4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IZV
Identifiers
Aliases	SOCS4, SOCS7, suppressor of cytokine signaling 4
External IDs	OMIM: 616337; MGI: 1914546; HomoloGene: 15442; GeneCards: SOCS4; OMA:SOCS4 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	55,049,489 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	47,533,559 bp
RNA expression pattern
	Top expressed in
	pancreatic epithelial cell; ; tibia; ; visceral pleura; ; parietal pleura; ; tail of epididymis; ; germinal epithelium; ; mucosa of ileum; ; mucosa of paranasal sinus; ; cardiac muscle tissue of right atrium; ; tibialis anterior muscle;
	Top expressed in
	medial ganglionic eminence; ; conjunctival fornix; ; vestibular membrane of cochlear duct; ; epithelium of small intestine; ; carotid body; ; atrioventricular valve; ; lymph node; ; trigeminal ganglion; ; lumbar spinal ganglion; ; hair follicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein kinase inhibitor activity; protein binding;
Cellular component	cytoplasm; intracellular anatomical structure;
Biological process	negative regulation of epidermal growth factor-activated receptor activity; regulation of growth; negative regulation of signal transduction; intracellular signal transduction; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; cytokine-mediated signaling pathway; negative regulation of receptor signaling pathway via JAK-STAT;
	Sources:Amigo / QuickGO
Orthologs
	122809
	67296
	ENSG00000180008
	ENSMUSG00000048379
	Q8WXH5
	Q91ZA6
	NM_080867; NM_199421
	NM_080843
	NP_543143; NP_955453
	NP_543119
	Wikidata
View/Edit Human	View/Edit Mouse

Suppressor of cytokine signaling 4 is a protein that in humans is encoded by the SOCS4 gene.^[5]

Function

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000180008 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048379 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Suppressor of cytokine signaling 4". Retrieved 2016-02-23.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Suppressor of cytokine signaling 4 (SOCS4)

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000180008 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048379 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Suppressor of cytokine signaling 4". Retrieved 2016-02-23.

[5]

[1]

[2]

[3]

[4]

SOCS4

Contents

Function

References

Further reading

External links