Location via proxy:   [ UP ]  
[Report a bug]   [Manage cookies]                

Suppressor of cytokine signaling 4 is a protein that in humans is encoded by the SOCS4 gene.[5]

SOCS4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSOCS4, SOCS7, suppressor of cytokine signaling 4
External IDsOMIM: 616337; MGI: 1914546; HomoloGene: 15442; GeneCards: SOCS4; OMA:SOCS4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_080867
NM_199421

NM_080843

RefSeq (protein)

NP_543143
NP_955453

NP_543119

Location (UCSC)Chr 14: 55.03 – 55.05 MbChr 14: 47.51 – 47.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

edit

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000180008Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048379Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Suppressor of cytokine signaling 4". Retrieved 2016-02-23.

Further reading

edit

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


edit
  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Suppressor of cytokine signaling 4 (SOCS4)