TAF7L

TATA-box binding protein associated factor 7 like is a protein that in humans is encoded by the TAF7L gene.

TAF7L
Identifiers
Aliases	TAF7L, CT40, TAF2Q, TATA-box binding protein associated factor 7 like
External IDs	OMIM: 300314; MGI: 1921719; HomoloGene: 83311; GeneCards: TAF7L; OMA:TAF7L - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xq22.1 Start 101,268,253 bp End 101,293,057 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X E3 Start 133,360,867 bp End 133,377,239 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis gonad testicle stromal cell of endometrium canal of the cervix nucleus accumbens skin of leg right lobe of liver seminal vesicula Top expressed in spermatid seminiferous tubule spermatocyte embryo decidua embryo Gonadal ridge ovary primary visual cortex superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function transcription coactivator activity transcription factor binding histone acetyltransferase binding molecular function Cellular component cytoplasm transcription factor TFIID complex nucleus Biological process regulation of transcription by RNA polymerase II multicellular organism development cell differentiation RNA polymerase II preinitiation complex assembly transcription initiation from RNA polymerase II promoter regulation of transcription, DNA-templated spermatogenesis transcription, DNA-templated biological process positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54457 74469 Ensembl ENSG00000102387 ENSMUSG00000009596 UniProt Q5H9L4 Q9D3R9 RefSeq (mRNA) NM_001168474 NM_024885 NM_028958 RefSeq (protein) NP_001161946 NP_079161 NP_083234 Location (UCSC) Chr X: 101.27 – 101.29 Mb Chr X: 133.36 – 133.38 Mb PubMed search
Wikidata
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Function

This gene is similar to a mouse gene that encodes a TATA box binding protein-associated factor, and shows testis-specific expression. The encoded protein could be a spermatogenesis-specific component of the DNA-binding general transcription factor complex TFIID. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009].

Further reading

• Stouffs K, Willems A, Lissens W, Tournaye H, Van Steirteghem A, Liebaers I (April 2006). "The role of the testis-specific gene hTAF7L in the aetiology of male infertility". Mol. Hum. Reprod. 12 (4): 263–7. doi:10.1093/molehr/gal020. PMID 16597641.
• Akinloye O, Gromoll J, Callies C, Nieschlag E, Simoni M (October 2007). "Mutation analysis of the X-chromosome linked, testis-specific TAF7L gene in spermatogenic failure". Andrologia. 39 (5): 190–5. doi:10.1111/j.1439-0272.2007.00789.x. PMID 17714218. S2CID 13317343.
• Yazarloo F, Shirkoohi R, Mobasheri MB, Emami A, Modarressi MH (March 2013). "Expression analysis of four testis-specific genes AURKC, OIP5, PIWIL2 and TAF7L in acute myeloid leukemia: a gender-dependent expression pattern". Med. Oncol. 30 (1): 368. doi:10.1007/s12032-012-0368-8. PMID 23292864. S2CID 20377221.
• Oh HR, An CH, Yoo NJ, Lee SH (July 2015). "Frameshift mutations of TAF7L gene, a core component for transcription by RNA polymerase II, in colorectal cancers". Pathol. Oncol. Res. 21 (3): 849–50. doi:10.1007/s12253-014-9832-4. PMID 25098277. S2CID 15595245.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.