BD1052

BD1052
Identifiers
	IUPAC name N-[2-(3,4-dichlorophenyl)ethyl]-N-2-propen-1-yl-1-pyrrolidineethanamine;
CAS Number	138356-16-8;
PubChem CID	9797436;
ChemSpider	7973202;
CompTox Dashboard (EPA)	DTXSID90430892 ;
Chemical and physical data
Formula	C17H24Cl2N2
Molar mass	327.294 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Clc1ccc(cc1Cl)CCN(CCN2CCCC2)C\C=C;
	InChI InChI=1S/C17H24Cl2N2/c1-2-8-20(12-13-21-9-3-4-10-21)11-7-15-5-6-16(18)17(19)14-15/h2,5-6,14H,1,3-4,7-13H2; Key:IKFDBDJFYBCATB-UHFFFAOYSA-N;

BD1052 or N-[2-(3,4-dichlorophenyl)ethyl]-N-2-propen-1-yl-1-pyrrolidineethanamine is a selective sigma receptor agonist, with a reported binding affinity of K_i = 2 ± 0.5 nM for the sigma-1 receptor and 30 times selectivity over the sigma-2 receptor.^[1]

Consistent with other reported sigma receptor agonists, pretreating Swiss Webster mice with BD1052 significantly increases the behavioral toxicity of cocaine.^[1]

References

^ ^a ^b Matsumoto RR, McCracken KA, Pouw B, Miller J, Bowen WD, Williams W, De Costa BR (2001). "N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice". Eur. J. Pharmacol. 411 (3): 261–73. {{cite journal}}: Cite has empty unknown parameter: |month= (help)CS1 maint: multiple names: authors list (link)

[Matsumoto_2001-1] Matsumoto RR, McCracken KA, Pouw B, Miller J, Bowen WD, Williams W, De Costa BR (2001). "N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice". Eur. J. Pharmacol. 411 (3): 261–73. {{cite journal}}: Cite has empty unknown parameter: |month= (help)CS1 maint: multiple names: authors list (link)

[1]

See also

References