Somatostatin receptor: Difference between revisions
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{{Short description|Cell surface protein binding somatostatin and triggering intracellular changes}} |
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[[File:⁹⁰Y-DOTATOC Structure.jpg|thumb|364x364px|Image showing somatostatin biochemical pathway complete with target cell somatostatin receptor]] |
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{{infobox protein |
{{infobox protein |
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| Name = [[somatostatin receptor 1]] |
| Name = [[somatostatin receptor 1]] |
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'''Somatostatin receptors''' are receptors for the [[ligand]] [[somatostatin]], a small [[neuropeptide]] associated with neural signaling, particularly in the [[post-synaptic]] response to [[NMDA receptor]] co-stimulation/activation. Somatostatin is encoded by a CRE and is very susceptible to gene [[Promoter (genetics)|promoter]] region activation by [[transcription factor]] [[CREB]].<ref>{{Cite book|title=Principles of Neurobiology|last=Lou|first=Liqun | name-list-style = vanc |publisher=Garland Science, Taylor and Francis Group|year= 2016|isbn=978-0-8153-4494-0|location=New York, NY|pages=109–110}}</ref> |
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| ⚫ | There are five known |
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| ⚫ | There are five known somatostatin receptors:<ref name="pmid7792934">{{cite journal |vauthors=Hoyer D, Bell GI, Berelowitz M, Epelbaum J, Feniuk W, Humphrey PP, O'Carroll AM, Patel YC, Schonbrunn A, Taylor JE | title = Classification and nomenclature of somatostatin receptors | journal = Trends Pharmacol. Sci. | volume = 16 | issue = 3 | pages = 86–8 | year = 1995 | pmid = 7792934 | doi = 10.1016/S0165-6147(00)88988-9 | doi-access = free }}</ref> |
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* [[somatostatin receptor 1|SST<sub>1</sub>]] ({{Gene|SSTR1}}) |
* [[somatostatin receptor 1|SST<sub>1</sub>]] ({{Gene|SSTR1}}) |
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{{G protein-coupled receptors}} |
{{G protein-coupled receptors}} |
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{{Neuropeptide receptors}} |
{{Neuropeptide receptors}} |
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{{GH/IGF-1 axis signaling modulators}} |
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{{Peptidergics}} |
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{{DEFAULTSORT:Somatostatin Receptor}} |
{{DEFAULTSORT:Somatostatin Receptor}} |
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{{transmembranereceptor-stub}} |
{{transmembranereceptor-stub}} |
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Latest revision as of 08:25, 29 January 2023
| somatostatin receptor 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | SSTR1 | ||||||
| NCBI gene | 6751 | ||||||
| HGNC | 11330 | ||||||
| OMIM | 182451 | ||||||
| RefSeq | NM_001049 | ||||||
| UniProt | P30872 | ||||||
| Other data | |||||||
| Locus | Chr. 14 q13 | ||||||
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| somatostatin receptor 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | SSTR2 | ||||||
| NCBI gene | 6752 | ||||||
| HGNC | 11331 | ||||||
| OMIM | 182452 | ||||||
| RefSeq | NM_001050 | ||||||
| UniProt | P30874 | ||||||
| Other data | |||||||
| Locus | Chr. 17 q24 | ||||||
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| somatostatin receptor 3 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | SSTR3 | ||||||
| NCBI gene | 6753 | ||||||
| HGNC | 11332 | ||||||
| OMIM | 182453 | ||||||
| RefSeq | NM_001051 | ||||||
| UniProt | P32745 | ||||||
| Other data | |||||||
| Locus | Chr. 22 q13.1 | ||||||
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| somatostatin receptor 4 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | SSTR4 | ||||||
| NCBI gene | 6754 | ||||||
| HGNC | 11333 | ||||||
| OMIM | 182454 | ||||||
| RefSeq | NM_001052 | ||||||
| UniProt | P31391 | ||||||
| Other data | |||||||
| Locus | Chr. 20 p11.2 | ||||||
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| somatostatin receptor 5 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | SSTR5 | ||||||
| NCBI gene | 6755 | ||||||
| HGNC | 11334 | ||||||
| OMIM | 182455 | ||||||
| RefSeq | NM_001053 | ||||||
| UniProt | P35346 | ||||||
| Other data | |||||||
| Locus | Chr. 16 p13.3 | ||||||
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Somatostatin receptors are receptors for the ligand somatostatin, a small neuropeptide associated with neural signaling, particularly in the post-synaptic response to NMDA receptor co-stimulation/activation. Somatostatin is encoded by a CRE and is very susceptible to gene promoter region activation by transcription factor CREB.[1]
There are five known somatostatin receptors:[2]
All are G protein-coupled seven transmembrane receptors.
References
[edit]- ^ Lou L (2016). Principles of Neurobiology. New York, NY: Garland Science, Taylor and Francis Group. pp. 109–110. ISBN 978-0-8153-4494-0.
- ^ Hoyer D, Bell GI, Berelowitz M, Epelbaum J, Feniuk W, Humphrey PP, O'Carroll AM, Patel YC, Schonbrunn A, Taylor JE (1995). "Classification and nomenclature of somatostatin receptors". Trends Pharmacol. Sci. 16 (3): 86–8. doi:10.1016/S0165-6147(00)88988-9. PMID 7792934.
External links
[edit]- Somatostatin+Receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
 | This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it. |