TAAR9

TAAR9
Identifiers
Aliases	TAAR9, TA3, TAR3, TAR9, TRAR3, trace amine associated receptor 9 (gene/pseudogene), trace amine associated receptor 9
External IDs	OMIM: 608282; MGI: 3527454; HomoloGene: 65286; GeneCards: TAAR9; OMA:TAAR9 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	132,539,336 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	23,985,432 bp
RNA expression pattern
	Top expressed in
	material anatomical entity;
	Top expressed in
	embryo; ; primary oocyte; ; secondary oocyte; ; zygote;
	More reference expression data
	n/a
Gene ontology
Molecular function	signal transducer activity; G protein-coupled receptor activity; trace-amine receptor activity;
Cellular component	plasma membrane; membrane; integral component of membrane;
Biological process	signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	134860
	503558
	ENSG00000237110
	ENSMUSG00000037424
	Q96RI9
	Q5QD04
	NM_175057
	NM_001010831
	NP_778227
	NP_001010831
	Wikidata
View/Edit Human	View/Edit Mouse

Trace amine-associated receptor 9 is a protein that in humans is encoded by the TAAR9 gene.^[5]^[6]

TAAR9 is a member of a large family of rhodopsin G protein–coupled receptors (GPCRs, or GPRs). GPCRs contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM]^[6] N-Methyl piperidine is a ligand of TAAR9 associated with aversive behavior in mice. N,N-dimethylcyclohexylamine is an additional binding agonist that also activaes TAAR7 variants.^[7]^[8]

TAAR9 gene deletion in rats leads to significantly decreased low-density lipoprotein cholesterol levels in the blood.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000237110 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037424 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics. 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.
^ ^a ^b "Entrez Gene: TAAR9 trace amine associated receptor 9".
^ Ferrero DM, Wacker D, Roque MA, Baldwin MW, Stevens RC, Liberles SD (July 2012). "Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity". ACS Chemical Biology. 7 (7): 1184–9. doi:10.1021/cb300111e. PMC 3401279. PMID 22545963.
^ Liberles SD (October 2015). "Trace amine-associated receptors: ligands, neural circuits, and behaviors". Current Opinion in Neurobiology. 34: 1–7. doi:10.1016/j.conb.2015.01.001. PMC 4508243. PMID 25616211.
^ Murtazina RZ, Zhukov IS, Korenkova OM, Popova EA, Kuvarzin SR, Efimova EV, et al. (March 2021). "Genetic Deletion of Trace-Amine Associated Receptor 9 (TAAR9) in Rats Leads to Decreased Blood Cholesterol Levels". International Journal of Molecular Sciences. 22 (6): 2942. doi:10.3390/ijms22062942. PMC 7998418. PMID 33799339.

Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, et al. (July 2001). "Trace amines: identification of a family of mammalian G protein-coupled receptors". Proceedings of the National Academy of Sciences of the United States of America. 98 (16): 8966–71. Bibcode:2001PNAS...98.8966B. doi:10.1073/pnas.151105198. PMC 55357. PMID 11459929.
Vanti WB, Muglia P, Nguyen T, Cheng R, Kennedy JL, George SR, O'Dowd BF (November 2003). "Discovery of a null mutation in a human trace amine receptor gene". Genomics. 82 (5): 531–6. doi:10.1016/S0888-7543(03)00173-3. PMID 14559210.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000237110 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037424 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15718104-5] Lindemann L, Ebeling M, Kratochwil NA, Bunzow JR, Grandy DK, Hoener MC (March 2005). "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics. 85 (3): 372–85. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104.

[entrez-6] "Entrez Gene: TAAR9 trace amine associated receptor 9".

[pmid22545963-7] Ferrero DM, Wacker D, Roque MA, Baldwin MW, Stevens RC, Liberles SD (July 2012). "Agonists for 13 trace amine-associated receptors provide insight into the molecular basis of odor selectivity". ACS Chemical Biology. 7 (7): 1184–9. doi:10.1021/cb300111e. PMC 3401279. PMID 22545963.

[pmid25616211-8] Liberles SD (October 2015). "Trace amine-associated receptors: ligands, neural circuits, and behaviors". Current Opinion in Neurobiology. 34: 1–7. doi:10.1016/j.conb.2015.01.001. PMC 4508243. PMID 25616211.

[Murtazina_2021-9] Murtazina RZ, Zhukov IS, Korenkova OM, Popova EA, Kuvarzin SR, Efimova EV, et al. (March 2021). "Genetic Deletion of Trace-Amine Associated Receptor 9 (TAAR9) in Rats Leads to Decreased Blood Cholesterol Levels". International Journal of Molecular Sciences. 22 (6): 2942. doi:10.3390/ijms22062942. PMC 7998418. PMID 33799339.

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TAAR9

See also

References

Further reading