Tenidap
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| Formula | C14H9ClN2O3S |
| Molar mass | 320.75086 g/mol g·mol−1 |
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Tenidap was a COX/5-LOX inhibitor and cytokine-modulating anti-inflammatory drug[1] that was under development by Pfizer as a promising potential treatment for rheumatoid arthritis,[2] but Pfizer halted development after marketing approval was rejected by the FDA in 1996[3] due to liver and kidney toxicity, which was attributed to metabolites of the drug with a thiophene moiety that caused oxidative damage.[4]
References
- ^ Attention: This template ({{cite pmid}}) is deprecated. To cite the publication identified by PMID 7543348, please use {{cite journal}} with
|pmid=7543348instead. - ^ Staff, American Journal of Nursing. Drug Watch: Tenidap Offers Arthritis Therapy Minus Toxicity AJN 1996 96(1):58
- ^ Pfizer. Sept 27, 1996 Press release: Pfizer To Halt Plans For Commercialization Of Tenidap For Rheumatoid Arthritis
- ^ Hwang SH et al. Rationally designed multitarget agents against inflammation and pain. Curr Med Chem. 2013;20(13):1783-99. PMID 23410172 PMC 4113248
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| salicylates | |
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| propionic acid derivatives (profens) |
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| COX-2 inhibitors (coxibs) | |
| other | |
| NSAID combinations | |
Key: underline indicates initially developed first-in-class compound of specific group; #WHO-Essential Medicines; †withdrawn drugs; ‡veterinary use. | |
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