From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Centrosome-associated protein 350 is a protein that in humans is encoded by the CEP350 gene .[ 5] [ 6] [ 7]
CEP350 is a large protein with a CAP-Gly domain typically found in cytoskeleton -associated proteins. It primarily localizes to the centrosome , a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. CEP350 is required to anchor microtubules at the centrosome. Furthermore, it increases the stability of growing centrioles .[ 8]
It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000135837 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033671 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Yan X, Habedanck R, Nigg EA (Jan 2006). "A Complex of Two Centrosomal Proteins, CAP350 and FOP, Cooperates with EB1 in Microtubule Anchoring" . Mol Biol Cell . 17 (2): 634–44. doi :10.1091/mbc.E05-08-0810 . PMC 1356575 PMID 16314388 . ^ Patel H, Truant R, Rachubinski RA, Capone JP (Dec 2004). "Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350" . J Cell Sci . 118 (Pt 1): 175–86. doi :10.1242/jcs.01600 PMID 15615782 . ^ a b "Entrez Gene: CEP350 centrosomal protein 350kDa" .^ Le Clech, M (2008). "Role of CAP350 in centriolar tubule stability and centriole assembly" . PLOS ONE . 3 (12): e3855. Bibcode :2008PLoSO...3.3855L . doi :10.1371/journal.pone.0003855 PMC 2586089 PMID 19052644 .
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem . 236 (1): 107–13. doi :10.1006/abio.1996.0138 . PMID 8619474 . Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 PMID 8889548 . Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing" . Genome Res . 7 (4): 353–8. doi :10.1101/gr.7.4.353 . PMC 139146 PMID 9110174 . Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain" . DNA Res . 4 (5): 345–9. doi :10.1093/dnares/4.5.345 PMID 9455484 . Makalowska I, Sood R, Faruque MU, et al. (2002). "Identification of six novel genes by experimental validation of GeneMachine predicted genes". Gene . 284 (1–2): 203–13. doi :10.1016/S0378-1119(01)00897-6 . PMID 11891061 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Andersen JS, Wilkinson CJ, Mayor T, et al. (2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature . 426 (6966): 570–4. Bibcode :2003Natur.426..570A . doi :10.1038/nature02166 . PMID 14654843 . S2CID 4427303 . Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 PMID 14702039 . Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome . 16 (12): 942–54. doi :10.1007/s00335-005-0075-2 . PMID 16341674 . S2CID 69278 . Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes" . Genome Res . 16 (1): 55–65. doi :10.1101/gr.4039406 . PMC 1356129 PMID 16344560 . Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle" . Proc. Natl. Acad. Sci. U.S.A . 103 (14): 5391–6. Bibcode :2006PNAS..103.5391N . doi :10.1073/pnas.0507066103 PMC 1459365 PMID 16565220 . Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1" . Nature . 441 (7091): 315–21. Bibcode :2006Natur.441..315G . doi :10.1038/nature04727 PMID 16710414 . Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration" . Cell . 125 (4): 801–14. doi :10.1016/j.cell.2006.03.032 PMID 16713569 . S2CID 13709685 . Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks" . Cell . 127 (3): 635–48. doi :10.1016/j.cell.2006.09.026 PMID 17081983 . S2CID 7827573 . Hoppeler-Lebel A, Celati C, Bellett G, et al. (2007). "Centrosomal CAP350 protein stabilises microtubules associated with the Golgi complex" . J. Cell Sci . 120 (Pt 18): 3299–308. doi :10.1242/jcs.013102 PMID 17878239 .
